Protein Alignment ppk22 and SCNN1D

DIOPT Version :10

• Sequence 1: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 113/583 - (19%)
• Similarity: 193/583 - (33%)
• Gaps: 192/583 - (32%)

  Fly    37 FCLDMADLVRNISLQGYNKLLSPDLTLGQRL---IWLLVHMATTVSLIVVLSLT----WEQFVAQ 94
            ||       .|.::.|..:|:   .:.|.||   .|.|:.:...|:|...|.|.    |.:.|..
Human   227 FC-------TNATIHGAIRLV---CSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLM 281

  Fly    95 SFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL------------------------ 135
            :...:.:..|.|:       |::|..|......|:::.|.|
Human   282 AVSVHSERKLLPL-------VTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALS 339

  Fly   136 ----RLNSPVIRPVEYFLERLR--------------------FFREFYTHVGVVVDTDDFITFQT 176
                |...|.....|..|:||.                    |:|.:.:.|..|.|
Human   340 ATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQD--------- 395

  Fly   177 FLDVFGTWNNETFFDTRRIMKMLTPRCQG-----FVLKCTVANVEVPCFSKDAFQDSLTMYGPCC 236
                   |.:..:.|...::........|     |||.|:...::  |.::.........||.|.
Human   396 -------WYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLD--CQARQFRTFHHPTYGSCY 451

  Fly   237 TFNMENKLKKRHFKNRLASSELGLKVVLNDSHVDYFAPILNT-NGYIVMIHNAENYASVYSSNVL 300
            |.:.....::....:       |:.:||......:. |:|:| .|..||:| ..|:......:..
Human   452 TVDGVWTAQRPGITH-------GVGLVLRVEQQPHL-PLLSTLAGIRVMVH-GRNHTPFLGHHSF 507

  Fly   301 EMFPGQGEDSYIAVCARVVDTDDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITR 365
            .:.|  |.::.|:     :..|:..:..||:. .|....|....  |.|.||   |||...|:..
Human   508 SVRP--GTEATIS-----IREDEVHRLGSPYG-HCTAGGEGVEV--ELLHNT---SYTRQACLVS 559

  Fly   366 CRIRSIIALCRCLPFQMPLQLVENLDGVVYCTLGHVSCLNQYIFKWRNILTERHIVNG-----LE 425
            |..:.::..|.|..:..||..     |..||:                  :.||...|     |.
Human   560 CFQQLMVETCSCGYYLHPLPA-----GAEYCS------------------SARHPAWGHCFYRLY 601

  Fly   426 REIE-EALYC-PQCLPSCRDVQYEVSM------SALPIDNYLATLKLDENNETEFGTDISVLRVY 482
            :::| ..|.| .:|...||:..:::|.      ||......||||          |..
Human   602 QDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATL----------GEQ------- 649

  Fly   483 FGDPHAQYYIR----LLNNTWFE----------------VFSTIGNIMSIFVGFSMVAIFEIL 525
             |.||..:..|    .:|..:.|                :.|.:|::.|::.|.|::::.|:|
Human   650 -GLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELL 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:459966	111/574 (19%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211
		ENaC	219..784	CDD:273304	113/583 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777