DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk22 and ASIC4

DIOPT Version :9

Sequence 1:	NP_733051.2	Gene:	ppk22 / 318593	FlyBaseID:	FBgn0051105	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	549	Identity:	118/549 - (21%)
Similarity:	198/549 - (36%)	Gaps:	130/549 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EHNSKGKRKES------LGS----AFCLDMADLVRNISLQGYNKLLSPDLTLGQRLIWLLVHMAT 76
            |.::|.|.||:      ||:    |...|:|......:|.|..:...|.....:|.:|.|..:.:
Human    13 EEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTS 77

  Fly    77 TVSLIVVLS------LTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL 135
            ..:.:...:      ||....||.       ||..|.....||||::|..||. |.:.:..|:..
Human    78 LAAFLYQAAGLARGYLTRPHLVAM-------DPAAPAPVAGFPAVTLCNINRF-RHSALSDADIF 134

  Fly   136 RL-NSPVIRPVEYFLERLRFFREFYTHVGVVVDTDDFITFQTFLDVFGTWNNETFFDTRRIMKML 199
            .| |...:.|.:         |:.:...|:.....|.:      |:.    |.|......::|
Human   135 HLANLTGLPPKD---------RDGHRAAGLRYPEPDMV------DIL----NRTGHQLADMLK-- 178

  Fly   200 TPRCQGFVLKCTVANVEVPCFSKDAFQDSLTMYGPCCTFNMENKLKKRHFKNRLASSELGLKVVL 264
              .|......|:.:|          |....|.||.|.|||.:   .:....:|......||:::|
Human   179 --SCNFSGHHCSASN----------FSVVYTRYGKCYTFNAD---PRSSLPSRAGGMGSGLEIML 228

  Fly   265 NDSHVDYFAPILNTN------GYIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCARVVDTDD 323
            :....:|......||      |..|.||:.|....::.   |......|..:::: |      .:
Human   229 DIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQ---LGFGVSPGFQTFVS-C------QE 283

  Fly   324 SLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQLVE 388
            ...::.|   :.:....|::.:.|..:..|| :|:...|..||...:::..|.|....||
Human   284 QRLTYLP---QPWGNCRAESELREPELQGYS-AYSVSACRLRCEKEAVLQRCHCRMVHMP----- 339

  Fly   389 NLDGVVYCTLG-HVSCLNQYIFKWRNILTERHIVNGLEREIEEALYCPQCLPSCRDVQY--EVSM 450
              .....|... ::.|.:             |.::.|....|...:||   ..|...:|  |:||
Human   340 --GNETICPPNIYIECAD-------------HTLDSLGGGPEGPCFCP---TPCNLTRYGKEISM 386

  Fly   451 SALP---IDNYLATLKLDENNETEFGTDISVLRVYFG-------DPHAQYYIRLLNNTWFEVFST 505
            ..:|   ...|||  :....|||....:..||.|:|.       :..|.|.:..|       ...
Human   387 VRIPNRGSARYLA--RKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL-------LGD 442

  Fly   506 IGNIMSIFVGFSMVAIFEILFFVTKYIYK 534
            :|..|.:|:|.|::.:.|||    .|||:
Human   443 LGGQMGLFIGASILTLLEIL----DYIYE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	105/506 (21%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	110/522 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152108
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850