DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk22 and ASIC5

DIOPT Version :9

Sequence 1:	NP_733051.2	Gene:	ppk22 / 318593	FlyBaseID:	FBgn0051105	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	525	Identity:	117/525 - (22%)
Similarity:	203/525 - (38%)	Gaps:	132/525 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VRNISLQGYNKLLSPDLTLGQRLIWLLVHMATTVSLIVVLSLTWEQFVAQ----SFVTNLKDPLF 105
            :.|| :|..:|:        :|::||:|.:. :|||:     ||:.::..    ::.|.....:.
Human    50 IHNI-VQNRSKI--------RRVLWLVVVLG-SVSLV-----TWQIYIRLLNYFTWPTTTSIEVQ 99

  Fly   106 PVENVPFPAVSICPNNRISRQAVIQYA---------------EELRLNSPVIRPVEYFLERLRFF 155
            .||.:.||||:.|..||....||.::.               :|:..||...|....|....:.|
Human   100 YVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNF 164

  Fly   156 R--EFYTHVGVVVDTDDFITFQTFLDVFGTWNNETFFDTRRIMKMLTPRCQGFVLKCTVANVEVP 218
            .  ||..:.|..:                  ||.|..|           |:.|         ..|
Human   165 SIVEFIRNKGFYL------------------NNSTLLD-----------CEFF---------GKP 191

  Fly   219 CFSKDAFQDSLTMYGPCCTFNMENKLKKRHFKNRLASSELGLKVVLN---DSHVDYFAPILNTNG 280
            |..|| |....|.||.|.|||....|:.   |.:::.|..||.::.|   ::..|..|......|
Human   192 CSPKD-FAHVFTEYGNCFTFNHGETLQA---KRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAG 252

  Fly   281 YIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCARVVDTDDSLKSFSPFSRRCYFEY---EAQ 342
            .|.:||         |...:..|.|.|..|.:.:.|||  |...:|:       .:.||   |..
Human   253 IIFVIH---------SPKKVPQFDGLGLLSPVGMHARV--TIRQVKT-------VHQEYPWGECN 299

  Fly   343 NPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQLVENLDGVVYCTL-GHVSCLNQ 406
            ..|..|..::||.|    .|:..|:.:.|...|.|:||.:|...:|       |.| .:.||::.
Human   300 PNIKLQNFSSYSTS----GCLKECKAQHIKKQCGCVPFLLPGYGIE-------CDLQKYFSCVSP 353

  Fly   407 YI--FKWRNILTERHIVNGLEREIEEALYCPQCLPSCRDVQY--EVSMSALPIDNYLATLKLDEN 467
            .:  .:::::.|             ...:...|..||.:::|  .:|.|:.|....|..|....|
Human   354 VLDHIEFKDLCT-------------VGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLN 405

  Fly   468 NETEF-GTDISVLRVYFGDPHAQYYIRLLNNTWFEVFSTIGNIMSIFVGFSMVAIFEILFFVTKY 531
            ...:: ..::..:.:.:.|.:.:...:....:..|:.:.:|..:.:|.|.|::.|.||:.::...
Human   406 QSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTN 470

  Fly   532 IYKGC 536
            .|..|
Human   471 FYWIC 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	115/513 (22%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	115/514 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7254
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770