Protein Alignment ppk22 and ASIC1

DIOPT Version :9

• Sequence 1: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 120/595 - (20%)
• Similarity: 202/595 - (33%)
• Gaps: 173/595 - (29%)

  Fly    30 KESLGSAFCLDMADLVRNISLQGYNKLLSPDLTLGQRLIWLLVHMATTVSLIVVLSLTWEQFVAQ 94
            :|.:|....:.:.....:.:|.|...:.|.:....:|.:|.|..:.:...|:.|.:...:.:...
Human     7 EEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHY 71

  Fly    95 SFVTNLKDPLFPVENVPFPAVSICPNN-----RISRQAVIQYAEELRL--NSPVIRPVEYFLERL 152
            ..||.|.:  .....:.||||::|..|     ::|:..:....|.|.|  |...|...:...|:
Human    72 HHVTKLDE--VAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEK- 133

  Fly   153 RFFREFYTHVGVVVDTDDFITFQTFLDVFGTWNNETFFDT--RRIMKMLTPRCQGFVLKCTVANV 215
                    .:.::.|..:|.:|:.     ..:|...|:|.  ..|..||        |.|....
Human   134 --------QLEILQDKANFRSFKP-----KPFNMREFYDRAGHDIRDML--------LSCHFRG- 176

  Fly   216 EVPCFSKDAFQDSLTMYGPCCTFNMENKLKKRHFKNRLASSELGLKVVLNDSHVDYFAPILNTN- 279
            || |.::| |:...|.||.|.|||.....:.| .|.....:..||:::| |...|.:.|:....
Human   177 EV-CSAED-FKVVFTRYGKCYTFNSGRDGRPR-LKTMKGGTGNGLEIML-DIQQDEYLPVWGETD 237

  Fly   280 ------GYIVMIHNA-----------------ENYASVYSSNVLEMFPGQGEDSYIAVCARVVDT 321
                  |..|.||:.                 :.:.:.....::.:.|..|      .| :.|..
Human   238 ETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWG------TC-KAVTM 295

  Fly   322 DDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQL 386
            |..|..|.                          ||:...|...|..|.::..|.|....||
Human   296 DSDLDFFD--------------------------SYSITACRIDCETRYLVENCNCRMVHMP--- 331

  Fly   387 VENLDGVVYCT-LGHVSCLNQYIFKWRNILTERHIVNGLEREIEEALYCPQCLPSCRDVQY--EV 448
                ....||| ..:..|.:..:    :.|.|:      ::|     || .|...|...:|  |:
Human   332 ----GDAPYCTPEQYKECADPAL----DFLVEK------DQE-----YC-VCEMPCNLTRYGKEL 376

  Fly   449 SMSALPID---NYLATLKLDENNETEFGTDISVLRVYF--------------------------- 483
            ||..:|..   .|||  |....:|...|.:|.||.::|
Human   377 SMVKIPSKASAKYLA--KKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGELLMTP 439

  Fly   484 ------GDPHAQYYIR----LLNNTW------FE---VFSTIGNIMSIFVGFSMVAIFEILFFVT 529
                  |...|.|:.:    ||::..      |.   ....||..|.:|:|.|::.:.|:..:..
Human   440 VPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAY 504

  Fly   530 KYI-YKGCNR 538
            :.| :|.|.|
Human   505 EVIKHKLCRR 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	114/565 (20%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	118/583 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850