DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk22 and asic1b

DIOPT Version :9

Sequence 1:	NP_733051.2	Gene:	ppk22 / 318593	FlyBaseID:	FBgn0051105	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	561	Identity:	123/561 - (21%)
Similarity:	213/561 - (37%)	Gaps:	132/561 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WIKNPKAAGEHNSKGKRKESLG-----SAFCLDMADLVRNISLQGYNKLLSPDLTLGQRL-IWLL 71
            |.|:.: .|::..:|...::..     .|..:.:|......||.|.|.:...|.....|. :|.|
Zfish    34 WSKDGE-QGKYQEEGDDPDAYDGPEDEEAPDISLATFFGGCSLHGANHVFVEDKKFSIRQGLWAL 97

  Fly    72 VH-MATTVSLIVVLSLTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL 135
            |. :|.::.|:.|:... ..::...:||.|.:.  ..:|:.|||:::| |....|::.:.|::.|
Zfish    98 VFLLAISMFLLQVVDRV-IYYLQYDYVTLLDER--NAKNMTFPAITLC-NYNTFRRSQLSYSDLL 158

  Fly   136 RLNSPVIRPVEYFLERLRFFREFYTHVGVVVDTDD----FITFQTFLDVFGT-WNNETFFDTRRI 195
                                     .:|.::..:|    .|......|..|: ::...||:..|
Zfish   159 -------------------------FMGPLLGYEDNMAPGIPLAPEPDRQGSRFSLAEFFNRTR- 197

  Fly   196 MKMLTPRCQGFVLKCTVANVEVPCFSKDAFQDSLTMYGPCCTFN--MENKLKKRHFKNRLASSEL 258
                 .|....:|:|..|..|  | ..:.:::..|.||.|.|||  .:.:......|..:.:
Zfish   198 -----HRMDDMLLECNFAGKE--C-GAEHWREIFTRYGKCYTFNSGQDGRPLLITTKGGMGN--- 251

  Fly   259 GLKVVLNDSHVDYFAPILNTN-------GYIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCA 316
            ||:::| |...|.:.|:....       |..|.||..:....:   :.|......|..:::: |
Zfish   252 GLEIML-DIQQDEYLPVWGETDETTFEAGIKVQIHTQDEPPFI---DQLGFGVAPGFQTFVS-C- 310

  Fly   317 RVVDTDDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRI----RSIIALCRC 377
                .:..|....|....|     ...||.....||||        ||.|||    |.::..|.|
Zfish   311 ----QEQRLTYLPPPWGDC-----KATPIDSDFFNTYS--------ITACRIDCETRYLVENCNC 358

  Fly   378 LPFQMPLQLVENLDGVVYCT-LGHVSCLNQYIFKWRNILTERHIVNGLEREIEEALYCPQCLPSC 441
            ....||       ....||| ..:..|.:..:    :.|.||           :..|| .|...|
Zfish   359 RMVHMP-------GDAPYCTPEQYKECADPAL----DFLVER-----------DNDYC-VCETPC 400

  Fly   442 RDVQY--EVSMSALPID---NYLATLKLDENNETE--FGTDISVLRVYFGDPHAQYYIRLLNNTW 499
            ...:|  |:|...:|..   .|||    .:.|:||  ...:|.||.::|   .|..|..:.....
Zfish   401 NMTRYGKELSFVRIPSKASAKYLA----KKYNKTEQYISDNIMVLDIFF---EALNYETIEQKKA 458

  Fly   500 FEVFSTIGNI---MSIFVGFSMVAIFEILFFVTKYI-YKGC 536
            :|:...:|:|   |.:|:|.|::.|.|:..::.:.| :|.|
Zfish   459 YELAGLLGDIGGQMGLFIGASILTILELFDYLYEVIKFKLC 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	114/511 (22%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57		3/21 (14%)
		ASC	66..548	CDD:295594	118/528 (22%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950