DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk22 and ppk12

DIOPT Version :9

Sequence 1:	NP_733051.2	Gene:	ppk22 / 318593	FlyBaseID:	FBgn0051105	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster

Alignment Length:	615	Identity:	137/615 - (22%)
Similarity:	234/615 - (38%)	Gaps:	153/615 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SKGKRKES----LGSAFCLDMADLVRNISLQGYNKLLSPDLTLGQRLIWL---LVHMATTVSLIV 82
            |.|..::.    |..:|...:...:...||.|...:....|:..:|..:|   :..:..||.||.
  Fly     6 SAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLIS 70

  Fly    83 VLSLTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAE---ELRLNSPVIRP 144
            .:.:.|:   :...:..:......:..|||||::||..|::.|..|..|.|   |..|...:...
  Fly    71 NIYVKWD---STPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKLLCES 132

  Fly   145 VEYFLERLRFFREFYTHVGVVVDTDDFITFQTFLDVFGTWNNETFFDTRRIMKMLTPRCQGFVLK 209
            ..:  |......||        ...:|:|....:..|.:.::::              |:..:|.
  Fly   133 DSW--ESSEADEEF--------SASNFVTNNLKISEFVSNHSQS--------------CERMLLF 173

  Fly   210 CTVANVEVPCFSKDAFQDSLTMYGPCCTFNME--NKLKKRHFKN--RLASSE------------- 257
            |..:.||..|  ...||..||..|.||.||.:  ..|.|....|  .|.:|:
  Fly   174 CRFSAVERNC--SQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGY 236

  Fly   258 -------------------LGLKVVLNDSHVDYFAPILNTNGYIVMIHNAENYASVYSSNVLEMF 303
                               ||...||:....:|:....|..|:.|..||......|..:.::...
  Fly   237 PEQLPPKFYPATASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAI 301

  Fly   304 PGQG-EDSYIAVCARVVDTDDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCR 367
               | |.:|.....| .:...:::|.|...|:|.|:       :|:.:..|.: ||..||...|.
  Fly   302 ---GYETNYRIEMVR-AEAVPAIRSISRDGRQCLFK-------NEKELIFYRI-YTRLNCENECL 354

  Fly   368 IRSIIALCRCLPFQMPLQLVENLDGVVYCTLGHVSCLNQYIFKWRNILTERHIVNGLEREIEEAL 432
            ...:...|.|:||..|| :..|..   .|::|..||:                     |..:.|.
  Fly   355 AAFLYDTCSCIPFDHPL-IYSNAS---ICSMGDTSCV---------------------RRAQRAS 394

  Fly   433 YCP-------QCLPSCRDVQYEVSMSALPI--DNY-LATLKLDENNETEFGTDISVLRVYFGDPH 487
            ..|       ||||||.|:.|..|..:.|:  :|: ||...::..|::....:|:|:.|||.:
  Fly   395 NRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRE-- 457

  Fly   488 AQYYIRLLNNT------WFEVFSTIGNIMSIFVGFSMVAIFEILFFV------TKYIYKGCNRMV 540
            :.||    .||      ..|..|.:|.:|.:|:|||::::.|||:|:      ..:::|..:.:.
  Fly   458 SVYY----GNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVWKRSSHVD 518

  Fly   541 EQNIMDRKAKELE------------TKKLY 558
            .:..:...|..:|            :|:||
  Fly   519 SEKSLKHNAFGIEKGQSSDNPSFWHSKELY 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	126/539 (23%)
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	126/542 (23%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	126/541 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456676
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	7	6.850