Protein Alignment ppk22 and Scnn1b

DIOPT Version :9

• Sequence 1: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 633
• Identity: 115/633 - (18%)
• Similarity: 211/633 - (33%)
• Gaps: 202/633 - (31%)

  Fly    11 IWWIKNPKAAGEHN--SKGKRKESLGSAFCLDMADLV---RNISLQGYNKLLSPDLTLGQRLIWL 70
            :|:..|....|...  .:|.:|:::.....|..|.||   ..:.:|.|
  Rat    27 VWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTY----------------- 74

  Fly    71 LVHMATTVSLIVVLSLTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL 135
                           |:||..|:.|         ...:.:.||||::|      ..:..||::..
  Rat    75 ---------------LSWEVSVSLS---------MGFKTMNFPAVTVC------NSSPFQYSKVK 109

  Fly   136 RLNSPVIRPVEYFLERLRFFREFYT------------HVGVVVDTDDFITFQTFLDVFGTWNNE- 187
            .|...:.:.:|..|:::...:..:|            |..:|:..:........|::||..:|.
  Rat   110 HLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSS 174

  Fly   188 ---------------------------TFFDTRRIMKMLTPRCQGFVLKCTVANVEVPCFSKDAF 225
                                       ||.:.....:.:|   :.::|:.|  |:    ||:...
  Rat   175 NPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQAVT---EWYILQAT--NI----FSQVLP 230

  Fly   226 QDSLTM------------------------------YGPCCTFNMENKLKKRHFKNRLASSELGL 260
            ||.:.|                              ||.|..||.  .:.::...:....:|.||
  Rat   231 QDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNW--GMTEKALPSANPGTEFGL 293

  Fly   261 KVVLNDSHVDYFAPILNTNGYIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCARVVDTDDSL 325
            |::|:....||...:.:|.|..:|:|....|..:....:..|   .|.::.|.|..      |.|
  Rat   294 KLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAM---AGTETSIGVLL------DKL 349

  Fly   326 KS----FSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQL 386
            :.    :||.:      ....:...:.|.:.|:.:|:...|:..|....:|..|.|..:..||..
  Rat   350 QGKGEPYSPCT------MNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPA 408

  Fly   387 VENLDGVVYCTLGHVSCLNQYIFKWRNILTERHIVNGLEREIEEALYC-PQCLPSCRDVQYE--V 448
                 |..||.       |:....|      .:....|:..:.:...| ..|..||.|.||:  :
  Rat   409 -----GEKYCN-------NRDFPDW------AYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTI 455

  Fly   449 SMSALP-------IDNYLATLKLDENNETEFGTDISVLRVYFGDPHAQYYIRLL------NNTWF 500
            ||:..|       |.:.|:..:...:|.|.....|..|.:||    .::..|.:      |..|
  Rat   456 SMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYF----QEFNYRTIEESPANNIVW- 515

  Fly   501 EVFSTIGNIMSIFVGFSMVAIFEILFFVTKYIY----------KGCNR 538
             :.|.:|.....::|.|::.:.|....:..:|:          ||..|
  Rat   516 -LLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	102/570 (18%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	115/633 (18%)
		deg-1	29..538	CDD:273309	109/605 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345605
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750