Protein Alignment ppk22 and Scnn1b

DIOPT Version :9

• Sequence 1: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_001258952.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Alignment Length: 631
• Identity: 120/631 - (19%)
• Similarity: 205/631 - (32%)
• Gaps: 198/631 - (31%)

  Fly    11 IWWIKNPKAAGEHN--SKGKRKESLGSAFCLDMADLV---RNISLQGYNKLLSPDLTLGQRLIWL 70
            :|:..|....|...  .:|.:|:::.....|..|.||   ..:.:|.|
Mouse    27 VWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFACLVCWQWGVFIQTY----------------- 74

  Fly    71 LVHMATTVSLIVVLSLTWEQFVAQSFVTNLKDPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL 135
                           |:||..|:.|         ...:.:.||||::|      ..:..||::..
Mouse    75 ---------------LSWEVSVSLS---------MGFKTMNFPAVTVC------NSSPFQYSKVK 109

  Fly   136 RLNSPVIRPVEYFLER--------------LRFFREFYTHVGVVVDTDDFITFQTFLDVFG---- 182
            .|...:...:|..||:              |.|  ..:.|..:|:..:........|::||
Mouse   110 HLLKDLDELMEAVLEKILAPEASHSNTTRTLNF--TIWNHTPLVLIDERNPDHPVVLNLFGDSHN 172

  Fly   183 --------TWN-------------NETFFDTRRIMKMLTPRCQGFVLKCTVANVEVPCFSKDAFQ 226
                    |.|             |.|....|..........:.::|:.|  |:    ||:...|
Mouse   173 SSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQAT--NI----FSQVLPQ 231

  Fly   227 DSLTM------------------------------YGPCCTFN---MENKLKKRHFKNRLASSEL 258
            |.:.|                              ||.|..||   .|..|...:     ..:|.
Mouse   232 DLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEETLPSAN-----PGTEF 291

  Fly   259 GLKVVLNDSHVDYFAPILNTNGYIVMIHNAENYASVYSSNVLEMFPGQGEDSYIAVCARVVDTDD 323
            |||::|:....||...:.:|.|..:|:|....|..:....:..|   .|.::.|.|.     .|.
Mouse   292 GLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAM---AGTETSIGVL-----VDK 348

  Fly   324 SLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRCRIRSIIALCRCLPFQMPLQLVE 388
            ..:...|:| .|  .....:...:.|.:.|:.:|:...|:..|....:|..|.|..:..||.
Mouse   349 LQRKGEPYS-PC--TMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLP--- 407

  Fly   389 NLDGVVYCTLGHVSCLNQYIFKWRNILTERHIVNGLEREIEEALYC-PQCLPSCRDVQYE--VSM 450
              :|..||.       |:....|      .:....|:..:.:...| ..|..||.|.||:  :||
Mouse   408 --EGEKYCN-------NRDFPDW------AYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISM 457

  Fly   451 SALP-------IDNYLATLKLDENNETEFGTDISVLRVYFGDPHAQYYIRLL------NNTWFEV 502
            :..|       |.:.|:..:...:|.|.....|..|.:||    .::..|.:      |..|  :
Mouse   458 ADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYF----QEFNYRTIEESPANNIVW--L 516

  Fly   503 FSTIGNIMSIFVGFSMVAIFEILFFVTKYIY----------KGCNR 538
            .|.:|.....::|.|::.:.|....:..:|:          ||..|
Mouse   517 LSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	107/568 (19%)
Scnn1b	NP_001258952.1	ENaC	21..621	CDD:273304	120/631 (19%)
		deg-1	29..538	CDD:273309	114/603 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842175
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750