Protein Alignment ppk22 and Scnn1a

DIOPT Version :9

• Sequence 1: NP_733051.2
• Gene: ppk22 / 318593
• FlyBaseID: FBgn0051105
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_035454.2
• Gene: Scnn1a / 20276
• MGIID: 101782
• Length: 700
• Species: Mus musculus
• Alignment Length: 558
• Identity: 107/558 - (19%)
• Similarity: 191/558 - (34%)
• Gaps: 118/558 - (21%)

  Fly    37 FCLDMADLVRNISLQGYNKLLSPDLTLGQRLIWLLVHMATTVSLIVVLSLTWEQFVAQSFVTNLK 101
            ||       .|.::.|..:|:.......:...|.::.:.|...:....:|.:|::.:.....|:.
Mouse    88 FC-------NNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNIN 145

  Fly   102 DPLFPVENVPFPAVSICPNNRISRQAVIQYAEEL------------RLNSPVIR----------- 143
               ...:.:.||||::|..|......:.:..|||            :.||...|
Mouse   146 ---LNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRD 207

  Fly   144 ---PVEYFLERL---------RFFREFYTHV---GVVVDTDD----------------FITFQTF 177
               .:.:.|:||         |..|...:.|   ...||..|                :.|:.:.
Mouse   208 LRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSG 272

  Fly   178 LDVFGTWNNETFFDTRRIMKMLTPRCQ-----GFVLKCTVANVEVPCFSKDAFQDSLTMYGPCCT 237
            :|....|....:.:....:...:|..:     .|:..|...  :.||...:..|....|||.|.|
Mouse   273 VDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFN--QAPCNQANYSQFHHPMYGNCYT 335

  Fly   238 FNMENKLKKRHFKNRLASSELGLKVVLNDSHVDYFAPILNT-NGYIVMIHNAENYASVYSSNVLE 301
            ||  ||.....:.:.:.....||.:.|.....| |.|:|:| .|..||:|..:..|.: ......
Mouse   336 FN--NKNNSNLWMSSMPGVNNGLSLTLRTEQND-FIPLLSTVTGARVMVHGQDEPAFM-DDGGFN 396

  Fly   302 MFPGQGEDSYIAVCARVVDTDDSLKSFSPFSRRCYFEYEAQNPIHEQLMNTYSLSYTFPNCITRC 366
            :.||             |:|..|::..:..|....:....:|.....:.|.|...||...||..|
Mouse   397 VRPG-------------VETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSC 448

  Fly   367 RIRSIIALCRCLPFQMPLQLVENLDGVVYCTLGHVSCLNQYIFKWRNILTERHIVNGLEREIEEA 431
            ...::|..|.|.....|     ...||.:|.....|......:|.:...:            .::
Mouse   449 FQENMIKKCGCAYIFYP-----KPKGVEFCDYLKQSSWGYCYYKLQAAFS------------LDS 496

  Fly   432 LYC-PQCLPSCRDVQYEVSM------SALPIDNYLATLKLDEN---NETEFGTDISVLRVYFGDP 486
            |.| .:|...|....|::|.      |....|.....|.|..|   |....|  ::.|.::|.:.
Mouse   497 LGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNG--VAKLNIFFKEL 559

  Fly   487 HAQYYIRLLNNTWFEVFSTIGNIMSIFVGFSMVAIFEI 524
            :.:......:.|...:.|.:|:..|::.|.|::::.|:
Mouse   560 NYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEM 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk22	NP_733051.2	ASC	46..527	CDD:279230	105/549 (19%)
Scnn1a	NP_035454.2	ENaC	80..677	CDD:273304	107/558 (19%)
		deg-1	88..600	CDD:273309	107/558 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842185
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750