Protein Alignment SmydA-9 and Smyd3

DIOPT Version :10

• Sequence 1: NP_572539.2
• Gene: SmydA-9 / 31859
• FlyBaseID: FBgn0030102
• Length: 500
• Species: Drosophila melanogaster
• Sequence 2: NP_081464.1
• Gene: Smyd3 / 69726
• MGIID: 1916976
• Length: 428
• Species: Mus musculus
• Alignment Length: 451
• Identity: 106/451 - (23%)
• Similarity: 165/451 - (36%)
• Gaps: 96/451 - (21%)

  Fly    34 GRGVVATRSLKRGEIIFRDSPLLIGLAAHEEDSLNACSVCLKMLPDTRFM-CRQGCGLPVCSLCA 97
            |.|:.|...|:.||::||..||...:.......:  |..||  |...:.| |.|......||...
Mouse    15 GNGLRAVAPLRPGELLFRSDPLAYTVCKGSRGVV--CDRCL--LGKEKLMRCSQCRIAKYCSAKC 75

  Fly    98 KKK---QHKSDCDLFKSWGPNEPD----VANSVIIRLLCVARAINLSKEQRDLIYCLQAN---LD 152
            :||   .|:.:|...||..|..|.    :...||::|:....:   ..|:....|.|::|   |.
Mouse    76 QKKAWPDHRRECSCLKSCKPRYPPDSVRLLGRVIVKLMDEKPS---ESEKLYSFYDLESNISKLT 137

  Fly   153 NNHRTEVRNAAKCFKNF-----------PTDKKLIEIMNRTVAVLRTNGFDKTTDRTNDNQEFNY 206
            .:.:..:|..|..|::|           |....|.|...:.:.    |.|   |....:.||...
Mouse   138 EDKKEGLRQLAMTFQHFMREEIQDASQLPPSFDLFEAFAKVIC----NSF---TICNAEMQEVGV 195

  Fly   207 RALYPLFGVVNHDCIPNAYYTFEEKTNNMIVRAAVDIPEGFEVTTTYTKLFTGNIARHLFLKMKK 271
             .|||...::||.|.||....|...  ::::||..:|..|.|:|..|..:...:..|...|:.:.
Mouse   196 -GLYPSMSLLNHSCDPNCSIVFNGP--HLLLRAVREIEAGEELTICYLDMLMTSEERRKQLRDQY 257

  Fly   272 SFTCKCSRCSDPTEKGAFISGLYCRDTNCTGLVVPEITGL----PHPNWNCLVC----------- 321
            .|.|.|.||....:....::|    |......|...:..:    .|..|..::.
Mouse   258 CFECDCIRCQTQDKDADMLTG----DEQIWKEVQESLKKIEELKAHWKWEQVLALCQAIINSNSN 318

  Fly   322 KQKSTHAQMMKSQDFASGA-INAKVNSNSL----RTLVQYLNEKSDSFIPSSNYV--VIDAKMSV 379
            :....:...:|..|.|..| ||..:...:|    ||:..|     ..|.|.|:.|  |...|:..
Mouse   319 RLPDINIYQLKVLDCAMDACINLGMLEEALFYAMRTMEPY-----RIFFPGSHPVRGVQVMKVGK 378

  Fly   380 LQRLQQGREDCSEELAHNTRLRYSRDITQLMDKLGLGDSLLR-TH------LEELLRREEE 433
            || |.||.                  ..|.|..|.|...::: ||      :|:|:...||
Mouse   379 LQ-LHQGM------------------FPQAMKNLRLAFDIMKVTHGREHSLIEDLILLLEE 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-9	NP_572539.2	SET	26..>49	CDD:394802	6/14 (43%)
		SET_SMYD	<183..280	CDD:380997	26/96 (27%)
Smyd3	NP_081464.1	SET_SMYD3	5..268	CDD:380980	70/269 (26%)
		zf-MYND	49..87	CDD:460312	12/39 (31%)
		C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000250|UniProtKB:Q9H7B4	272..428		36/177 (20%)