Protein Alignment SmydA-9 and SMYD3

DIOPT Version :10

• Sequence 1: NP_572539.2
• Gene: SmydA-9 / 31859
• FlyBaseID: FBgn0030102
• Length: 500
• Species: Drosophila melanogaster
• Sequence 2: NP_001161212.1
• Gene: SMYD3 / 64754
• HGNCID: 15513
• Length: 428
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 113/462 - (24%)
• Similarity: 168/462 - (36%)
• Gaps: 104/462 - (22%)

  Fly    29 VSKIA----GRGVVATRSLKRGEIIFRDSPLLIGLAAHEEDSLNACSVCLKMLPDTRFM-CRQGC 88
            |.|.|    |.|:.|...|:.||::||..||...:.......:  |..||  |...:.| |.|..
Human     6 VEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVV--CDRCL--LGKEKLMRCSQCR 66

  Fly    89 GLPVCSLCAKKK---QHKSDCDLFKSWGPNEPD----VANSVIIRLLCVARAINLSKEQRDLIYC 146
            ....||...:||   .||.:|...||..|..|.    :...|:.:|:..|.:   ..|:....|.
Human    67 VAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPS---ESEKLYSFYD 128

  Fly   147 LQANLDNNHRTE-----VRNAAKCFKNF-----------PTDKKLIEIMNRTVAVLRTNGFDKTT 195
            |::|:  |..||     :|.....|::|           |....|.|...:.:.    |.|   |
Human   129 LESNI--NKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC----NSF---T 184

  Fly   196 DRTNDNQEFNYRALYPLFGVVNHDCIPNAYYTFEEKTNNMIVRAAVDIPEGFEVTTTYTKLFTGN 260
            ....:.||... .|||...::||.|.||....|...  ::::||..||..|.|:|..|..:...:
Human   185 ICNAEMQEVGV-GLYPSISLLNHSCDPNCSIVFNGP--HLLLRAVRDIEVGEELTICYLDMLMTS 246

  Fly   261 IARHLFLKMKKSFTCKCSRCSDPTEKGAFISGLYCRDTNCTGLVVPEITGL----PHPNWNCLVC 321
            ..|...|:.:..|.|.|.||....:....::|    |......|...:..:    .|..|..::.
Human   247 EERRKQLRDQYCFECDCFRCQTQDKDADMLTG----DEQVWKEVQESLKKIEELKAHWKWEQVLA 307

  Fly   322 -----------KQKSTHAQMMKSQDFASGA-INAKVNSNSL----RTLVQYLNEKSDSFIPSSNY 370
                       :....:...:|..|.|..| ||..:...:|    ||:..|     ..|.|.|:.
Human   308 MCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-----RIFFPGSHP 367

  Fly   371 V--VIDAKMSVLQRLQQGREDCSEELAHNTRLRYSRDITQLMDKLGLGDSLLR-TH------LEE 426
            |  |...|:..|| |.||.                  ..|.|..|.|...::| ||      :|:
Human   368 VRGVQVMKVGKLQ-LHQGM------------------FPQAMKNLRLAFDIMRVTHGREHSLIED 413

  Fly   427 LLRREEE 433
            |:...||
Human   414 LILLLEE 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-9	NP_572539.2	SET	26..>49	CDD:394802	9/23 (39%)
		SET_SMYD	<183..280	CDD:380997	27/96 (28%)
SMYD3	NP_001161212.1	SET_SMYD3	5..268	CDD:380980	76/280 (27%)
		zf-MYND	49..87	CDD:460312	13/39 (33%)
		C-terminal domain, essential for histone methyltransferase activity, nuclear localization and mediates interaction with HSP90AA1. /evidence=ECO:0000269|PubMed:25738358	272..428		37/177 (21%)