Protein Alignment SmydA-9 and SMYD1

DIOPT Version :10

• Sequence 1: NP_572539.2
• Gene: SmydA-9 / 31859
• FlyBaseID: FBgn0030102
• Length: 500
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 96/500 - (19%)
• Similarity: 158/500 - (31%)
• Gaps: 191/500 - (38%)

  Fly    26 EIGVSKIAGRGVVATRSLKRGEIIFRDSPL-------LIGLAAH----EEDSLNACSVCLKMLPD 79
            |:..::..|||:.||:.....:|||.:...       |:....|    .::.|:.|..| |....
Human    10 EVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQEKLHRCGQC-KFAHY 73

  Fly    80 TRFMCRQGCGLPVCSLCAKKKQHKSDCDLFKSWG--PNEPDVANSVIIRLLCVARAI-NLSKEQR 141
            ....|::...|          .||::|...|.:|  |||.       |||  .||.: .:.:|..
Human    74 CDRTCQKDAWL----------NHKNECSAIKRYGKVPNEN-------IRL--AARIMWRVEREGT 119

  Fly   142 DLIYCLQANLDN--NH--------RTEVRNAAKCFKNF--PTDKKL-IEIMNRTVAVLRTNGFDK 193
            .|......::|:  ||        :.::|.....|..:  |..::. ::.::....|:..|||..
Human   120 GLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTL 184

  Fly   194 TTDRTNDNQEFNYRA----LYPLFGVVNHDCIPNAYYTFEEKTNNMI-----------VRAAVDI 243
            :..|       ..:|    ::|..|:|||||.||....|....:..:           :||...|
Human   185 SDQR-------GLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKI 242

  Fly   244 PEGFEVTTTYTKLFTGNIARHLFLKMKKSFTCKCSRCSDPTEKGAFI------------------ 290
            .||.|:|.:|......:..|...||.:..|.|.|..|....:...|:
Human   243 SEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQEVVKEMIQ 307

  Fly   291 --------------SGLY------CR-----------DTNCTGL----VVPEITG---------- 310
                          .|||      ||           |||...|    :|.|:..
Human   308 FSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASF 372

  Fly   311 -----------LPHP---------------NWNC--------LVCK------------------- 322
                       |.||               ||:.        ::||
Human   373 YARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDL 437

  Fly   323 -----QKSTHAQMMKSQDFASGAI-NAKVNSNSLRTLVQYLNEKS 361
                 |.....:|.:..:|....: .|.:|:..::.:.:..||.|
Human   438 EAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNEPS 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-9	NP_572539.2	SET	26..>49	CDD:394802	6/22 (27%)
		SET_SMYD	<183..280	CDD:380997	30/111 (27%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	69/297 (23%)
		zf-MYND	52..90	CDD:460312	9/48 (19%)