DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31077 and Mur89F

DIOPT Version :9

Sequence 1:	NP_733185.2	Gene:	CG31077 / 318583	FlyBaseID:	FBgn0051077	Length:	988	Species:	Drosophila melanogaster
Sequence 2:	NP_001262662.1	Gene:	Mur89F / 42080	FlyBaseID:	FBgn0038492	Length:	2159	Species:	Drosophila melanogaster

Alignment Length:	1213	Identity:	223/1213 - (18%)
Similarity:	339/1213 - (27%)	Gaps:	435/1213 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDSVKC-TEGSVAADIDDCASYFQCIDD-----ETVHLNCANGSYFEASNEIC------------ 77
            |.:.|| :|.:..||.::|:.:::|:|:     ..|...|...:.::.....|
  Fly  1017 KPAEKCESEETFLADNENCSKFYRCVDNGKGGFTKVSFTCPPNTLWDPEANSCNHPDQIQTKPLK 1081

  Fly    78 ---VVDEFGVC--PTSRRLCFDGDIFEDINDCMSYVKCI-------------------------R 112
               ||.:.|..  .||.......:.....|...|.....                         :
  Fly  1082 CKKVVSQGGSSSNSTSNSSSSSNNSGSSSNSGSSSSSSSSNSGSSSNTGSSSNSGASSSGGSSNQ 1146

  Fly   113 GDLVRQRCPAGSNF-----------------------NVISKNCQMSRTGSCASPKEIC-LEGEL 153
            |........:|||.                       :..|.:...|.|.|..:|.|.| :.|:.
  Fly  1147 GSSSNSGSSSGSNSSGNQSTSSSTSSSSSSSNNNNQGSSSSSSSSSSSTSSKPNPSETCKVNGQF 1211

  Fly   154 QVDSEDCAGYLECLN---GG--LVKEKCPIGSYFEPIFKLCQ-----LDENGVCSSSSSECTDGE 208
            ..|..|||.:..|::   ||  :|...|..|:.::...:.|.     .:..|:...::|..|...
  Fly  1212 IGDRSDCAKFYRCVDNDRGGFNMVPFSCGPGTVWDAQMQACNHAWAVKECGGIAPPTTSTPTTSR 1276

  Fly   209 VRVDPNNCAGYFNCENGRLITKTC---PSG------------TYFEPTYKTCTVDLKGVCVEP-- 256
                |...:      ..|...:|.   |:|            |...||..:.:.....|...|
  Fly  1277 ----PTTAS------TSRPSDQTSTSRPTGPPTTARPVTARPTTSSPTTASSSQTTSPVTQAPNT 1331

  Fly   257 PAKCTEGQLKIDPNNCAGYLKCI---DGEF--VEEKCPGGTYYDFKLETCLVDTEGVCVTIRKLC 316
            ..||.......|||||:.:.:|:   .|.|  :..:|..||.:|..|:||..:...        |
  Fly  1332 DGKCRSEGFMADPNNCSKFYRCVRNNKGGFTSIPFQCGAGTVWDQDLQTCNHNFNN--------C 1388

  Fly   317 IEGLREKDPK-DCAAYTQCIRGRVESVMCDSGRYFNVTQGECLADLYEVCLKSRKEHFRIVEHHQ 380
            ..|.....|| .|...|........|        ...|......||........
  Fly  1389 STGTESTTPKPPCEPATNGTTATSTS--------STTTPPPTTTDLPPTSTTGL----------- 1434

  Fly   381 YDESTTPNSYQQTESTD------------------------------ADFQSTDSALQEVTSQNS 415
              ..||......|.:||                              ...|.|.:.|...|..::
  Fly  1435 --PPTTTTELPPTTTTDLPPTTTTRLPPTTTTSLPPTTTTGLPPTTTTGAQPTTTTLSSETETST 1497

  Fly   416 CIFDLNGACVGQSTI----------CTEGKKQRDINNCAGYLKCIDG-------EFVEEECPEST 463
            ............||.          ||......|..:|..|.:||:.       .|.   ||:.|
  Fly  1498 VTTSPESTTQPPSTTTMKPLPAGTECTGEGYMADPEDCRKYYRCINAGASYRKYNFT---CPKGT 1559

  Fly   464 YYDSNLETC-LVDNYGAC-------VTSTSICVEGIVEEDPKDCAGYNQCVRGKVEPLKCAFGRY 520
            .::..::|| .|:|...|       :|:|.       .|:.||        .|...|.
  Fly  1560 GWNEEVQTCDYVENIPRCSKLPAEPITTTP-------SEESKD--------PGSTTPQ------- 1602

  Fly   521 FNGTQGECLIDLDEVCAKSSQVDYDRDLEQ----------FQYSQ--------------STSEYL 561
                      ..||....:..:  .:..|:          .||.:              :|:||.
  Fly  1603 ----------STDEPTTVTKPI--TKPTEEPSTEKPQKPTTQYPEKPTTTEEPEKPQKPTTTEYP 1655

  Fly   562 LEYTNTD---------TTIADF-----STESSNADFNRYTDSNSY----TDTESTTNDV----PT 604
            .:.|.|:         .|..::     :||....:..:...:..|    |..|.||..:    ||
  Fly  1656 QKPTTTEEPTPEKPQKPTTTEYPQKPTTTEEPTPEKPQKPTTTEYPQKPTTEEPTTTSIPGYNPT 1720

  Fly   605 STEVSTFDLKTTDLSLQFTTLDGVDNLDINTGTCVYNNTL---FIEGIRE--------------- 651
            :|.|..::..||.:.:: ||..........||..:...||   ..:.|:|
  Fly  1721 TTSVPGYNPTTTPIPVE-TTTSTPGYKPTTTGEPITTTTLPSTTTDAIQEPTTSKKPEPTTTTES 1784

  Fly   652 -----------------------------VNPQDCAGYIECFGGVAKE-------LKCDSG---- 676
                                         .:|:||:.|..|. ..||.       .||..|
  Fly  1785 PESSTPEGSVTTLQPEPQPNYNCSSEGFFPDPEDCSRYYRCV-DAAKNGKYQVYAFKCGKGTVWD 1848

  Fly   677 ------RYFNETQRNCS------------VDVDEICLKSDK----------TIVLDLQTTTESTP 713
                  .|.::...|||            ....|....|.|          |.....:|||.|:|
  Fly  1849 TSTETCNYADQVSGNCSSGQTTTPGTTTEPGTTESTTSSGKPETTSKAPENTTTWAPETTTTSSP 1913

  Fly   714 NFTTSV--DPFAKCRDGQLRLDPKNCAGFLK----CVDGE---------LKEEMCPSGFFYNSTS 763
            ..||:|  :.............|:......|    .:.||         ..|...||    .:||
  Fly  1914 ETTTTVASETTTTTSGTTTTATPETTTKPPKPETTTIAGEETSTSKSPTTTESPAPS----TNTS 1974

  Fly   764 SKCMVDIRATCVTNIKYCIEGVREEDPNNCAGYRQCIRGLVQN-LN-----CPLGQYFN------ 816
            :.|.   ......|:..|..|.|.. |..|..:.||......| ||     ||.|..:.
  Fly  1975 APCP---ETGPGQNVYVCPTGFRRH-PEKCGMFYQCSESADNNDLNIVVFQCPNGTVYQDKSCSC 2035

  Fly   817 ---VAERDCLMDVHKVCARTEEVYKSDEVQHNDTGPPMTKPDESCIRDINGVCVDPLAKCREGQH 878
               .|...|..|:.:.....||..|...|....|..|:              |.|      ||..
  Fly  2036 GKPPAGDKCSKDMKRTTNAFEEETKLQNVVQISTTDPL--------------CPD------EGHF 2080

  Fly   879 KLDPNNCAG-YLKCQNGELIEEL------CPNGFYYDFLMKIC 914
            .|:.:.|.. ::||...||...:      ||.||.|..:.:.|
  Fly  2081 ALNNDQCGQLFVKCGFSELTGRIEGQIHRCPQGFAYWNVSRRC 2123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31077	NP_733185.2	CBM_14	43..81	CDD:279884	10/57 (18%)
		ChtBD2	<212..245	CDD:214696	8/47 (17%)
		CBM_14	267..308	CDD:279884	15/45 (33%)
		CBM_14	439..472	CDD:279884	9/39 (23%)
		CBM_14	733..769	CDD:279884	10/48 (21%)
		CBM_14	881..914	CDD:279884	10/39 (26%)
Mur89F	NP_001262662.1	CBM_14	57..106	CDD:279884
		CBM_14	200..250	CDD:279884
		CBM_14	484..536	CDD:279884
		CBM_14	745..798	CDD:279884
		CBM_14	1025..1074	CDD:279884	9/48 (19%)
		CBM_14	1206..1261	CDD:279884	12/54 (22%)
		CBM_14	1336..1388	CDD:279884	15/59 (25%)
		CBM_14	1523..1577	CDD:279884	15/56 (27%)
		VAD1-2	<1599..>1656	CDD:291956	9/75 (12%)
		CBM_14	1809..1861	CDD:279884	11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100