back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(r) and Dpyd

DIOPT Version :9

Sequence 1:	NP_727320.1	Gene:	su(r) / 31858	FlyBaseID:	FBgn0086450	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	NP_112289.2	Gene:	Dpyd / 81656	RGDID:	621218	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	667/1028 - (64%)
Similarity:	793/1028 - (77%)	Gaps:	30/1028 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTLS 70
            :||:|:||||.:|:||||::...::..|...|.:|||||||.|.....|..|.|:|.|||||||.
  Rat     4 VLSRDAPDIESILALNPRIQAHATLRSTMAKKLDKKHWKRNTDKNCFTCEKLENNFDDIKHTTLG 68

  Fly    71 ERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPTS 135
            |||||.||.||||||||||||||||.||||||||||||||:|||||.||||||||||||||||||
  Rat    69 ERGALREAVRCLKCADAPCQKSCPTSLDIKSFITSIANKNYYGAAKLIFSDNPLGLTCGMVCPTS 133

  Fly   136 DLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTP-------QAEANPLSQKIALVGGG 193
            |||||||||.|:|.|||||||||||||||||.|.:.|.|:|       ..||  .|.||||.|.|
  Rat   134 DLCVGGCNLHATEEGPINIGGLQQFATEVFKAMNIPQIRSPLLPPPEHMPEA--YSAKIALFGAG 196

  Fly   194 PASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSL 258
            |||:|||:|||||||.|:||:|::.|:||||.:||||:|||.|.|||||:|::||||:|..|:|:
  Rat   197 PASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSI 261

  Fly   259 GTKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKA 323
            .|.::|:..|...|:.|.|:||||||||.:.||.||....||||||:|||||:.|||||:|||.:
  Rat   262 STDEMTLSTLKENGYKAAFIGIGLPEPKKDHIFQGLTQVQGFYTSKDFLPLVAKGSKPGMCACHS 326

  Fly   324 AAGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLP 388
            .  ||.:.|.||||||||||||||||||||||||||:|||||.:.|||||||:|||::|:||.||
  Rat   327 P--LPSVRGAVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFANIRAVPEEMELAKEEKCEFLP 389

  Fly   389 YLSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPL 453
            :|||||||||||.|..|:|.||||:|...|||||||..||||:.|||||||.|:|..|..||:|:
  Rat   390 FLSPRKVIVKDGKIVGMQFVRTEQDETGNWVEDEEQIVRLKADVVISAFGSVLDDPKVIEALSPI 454

  Fly   454 QF-RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQ---GLPLDTPA 514
            :| |..||.|:..|||:|...||.|||:.|:||||||||||||.|:|.||..:|   |..:.:..
  Rat   455 KFNRWGLPEVNPETMQTSEPWVFAGGDVVGMANTTVESVNDGKQASWYIHKYIQAQYGALVPSQP 519

  Fly   515 ALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVT 579
            .||||||.:|.|||||||.|:||.||||||||.|.|||.|||||||.||||.:||||.||||:||
  Rat   520 TLPLFYTPVDLVDISVEMAGLRFPNPFGLASATPATSTPMIRRAFEAGWGFALTKTFSLDKDIVT 584

  Fly   580 NVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEED 644
            ||||||:||||||..|||.|..||||||||||.|.||..|:.|||.|||:.|:|||||||:|:.|
  Rat   585 NVSPRIIRGTTSGPLYGPGQSSFLNIELISEKTAAYWCHSVTELKADFPDNILIASIMCSYNKND 649

  Fly   645 WTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPNI 709
            |.||:..||.||||||||||||||||||||||||||||||||..|.||||::|::|||.|||||:
  Rat   650 WMELSKMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQSVRVPFFAKLTPNV 714

  Fly   710 TDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAIS 774
            |||||||.|||.|||||.:|.|||.||||||||.:.||::|..:|||||||||.|.||:||:|::
  Rat   715 TDIVSIARAAKEGGADGVTATNTVSGLMGLKADGSPWPSVGSGKRTTYGGVSGTAIRPIALRAVT 779

  Fly   775 DIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANP 839
            .||..:||||||..|||||.|..|||:|:||:|||:||::|||||||||||||.||||||||:..
  Rat   780 AIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIE 844

  Fly   840 PPVDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPY--QRQRDIKMAELRSQKGALWDAE 902
            ...|   ||||||||..|||||||..:.......|..||||  :|::.:..:::|       :.:
  Rat   845 ELSD---WDGQSPPTMSHQKGKPVPHIAELMGQKLPSFGPYLERRKKILAASKIR-------EKD 899

  Fly   903 QVKATPPASN---GAPNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCA 964
            |.:|..|...   .:..|.|.||||||.:|..:|::.:|:..:|.|||||::||||||||||||.
  Rat   900 QNRACSPLQRKHFNSQKPIPAIKDVIGKSLQYLGTFGELNVMEQVVALIDEEMCINCGKCYMTCN 964

  Fly   965 DSGYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGV 1017
            |||||||:||.:||:|.|:|.|||||||:|||||:|||.||.:..|:..|||:
  Rat   965 DSGYQAIQFDPETHLPTVSDTCTGCTLCLSVCPIMDCIRMVSRATPYEPKRGL 1017

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.