DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(r) and dpyda.1

DIOPT Version :9

Sequence 1:	NP_727320.1	Gene:	su(r) / 31858	FlyBaseID:	FBgn0086450	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	XP_017209335.2	Gene:	dpyda.1 / 768165	ZFINID:	ZDB-GENE-061013-727	Length:	1023	Species:	Danio rerio

Alignment Length:	1038	Identity:	673/1038 - (64%)
Similarity:	804/1038 - (77%)	Gaps:	39/1038 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QLLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTL 69
            ::|||:.||||.:|:|||||:|..:::.|:..|..||.|||||:.....|..|.|:|.|||||||
Zfish     3 RMLSKELPDIESILALNPRVQTHAALLSTRTKKMEKKQWKRNAEKGCESCVKLENNFDDIKHTTL 67

  Fly    70 SERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPT 134
            ||||||.||.||||||||||||||||.|:||:|||||||||:||||:||.|||||||||||||||
Zfish    68 SERGALREAVRCLKCADAPCQKSCPTNLNIKAFITSIANKNYYGAARAILSDNPLGLTCGMVCPT 132

  Fly   135 SDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQAEANPLSQ-------KIALVGG 192
            ||||||||||.|||.|||||||||||||:|||:|||.|.|.|  :..|..|       ||||:|.
Zfish   133 SDLCVGGCNLYASEEGPINIGGLQQFATDVFKQMGVPQIRNP--DLPPPDQMPEIYHSKIALIGC 195

  Fly   193 GPASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRS 257
            ||||:|||:|||||||.:::::|::.::||||::||||:|||.|.|.||:||::||||:|...|.
Zfish   196 GPASISCASFLARLGYDNISVFEKQRFIGGLSSSEIPQFRLPYDVVQFEVDLMKDLGVKIVCDRG 260

  Fly   258 LGTKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACK 322
            ||...:|:..|...|:.|||:|||||:...:.:|.||...:||||||:|||||:..||||:|.|.
Zfish   261 LGQDGMTLLSLKEEGYKAVFIGIGLPQANRHKLFDGLSTEHGFYTSKDFLPLVAKASKPGMCGCV 325

  Fly   323 AAAGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELL 387
            :|  ||.|.|.||||||||||||||||||||||||||||||||.:.|||||||:|||::|:||.|
Zfish   326 SA--LPDLCGTVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMELAKEEKCEFL 388

  Fly   388 PYLSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAP 452
            |:||||:|::|.|.:..||||||||.|:.:|||||||..||||:|:||||||.::|..|..|:||
Zfish   389 PFLSPREVLLKGGRVHGMEFCRTEQTESGQWVEDEEQIIRLKADFIISAFGSMMKDPAVMEAMAP 453

  Fly   453 LQF-RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQ---GLPLDTP 513
            ::. |..||.:|..:||:|...||.|||:||:||||||:|||||.|:|.:|..||   ||.:..|
Zfish   454 VRLNRWGLPDLDLESMQTSEPWVFAGGDVAGLANTTVEAVNDGKQASWHMHKYLQSNFGLMVSGP 518

  Fly   514 AALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLV 578
            ..|||||:.||.||||||||||.|.|||||||||||||.|||||||||||||.:||||.|:||||
Zfish   519 PRLPLFYSPIDTVDISVEMCGITFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFSLNKDLV 583

  Fly   579 TNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEE 643
            ||||||||||:|||..:||.||.||||||||||.|.||.:|:.|||.|||:.|||:|||||:|:.
Zfish   584 TNVSPRIVRGSTSGPLFGPGQGSFLNIELISEKTAAYWCQSVRELKADFPDNIVISSIMCSYNKA 648

  Fly   644 DWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPN 708
            ||||||..||:||||||||||||||||||||||||||||||||..|.||||:||..|||.|||||
Zfish   649 DWTELAKMAEESGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVHTPFFAKLTPN 713

  Fly   709 ITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAI 773
            :|:||.||.||:.|||||.:|.|||.||||||||.:.|||||:.:|:|||||||||.||:||:|:
Zfish   714 VTNIVDIAKAAQEGGADGVTATNTVSGLMGLKADGSPWPAIGRGRRSTYGGVSGNAIRPIALRAV 778

  Fly   774 SDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKAN 838
            |.||..:|.||||..|||||.|.||||:||||||||:||:||||||||||||||.||||||||:.
Zfish   779 SAIAKALPDFPILATGGIDSAESALQFLHAGATVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSI 843

  Fly   839 PPPVDGPFWDGQSPPTPVHQKGKPVVRLTG-EGKATLGFFGPY-QRQRDI-----KMAELRSQKG 896
            ....|   ||||||||..|.:||||..|.. :||. |..|||| |.::::     |..:..|...
Zfish   844 EELQD---WDGQSPPTVRHHRGKPVPLLEEFKGKC-LPSFGPYLQEKKEVIANHKKKLKNYSNNP 904

  Fly   897 ALWDAEQV---KATPPASNGAPNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGK 958
            ...|..:|   ||          |||::||:||.||..||:|.:|:.::|..||||.:|||||||
Zfish   905 VSLDKTRVYTLKA----------PAPKVKDMIGKALKHIGAYQELNIQEQVQALIDPEMCINCGK 959

  Fly   959 CYMTCADSGYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGVEEKI 1021
            |||||.|:|||||.||.|||:|.|.|.|||||||:|||||||||.||.:..|:|.|||:.|.:
Zfish   960 CYMTCNDAGYQAIVFDPDTHLPSVQDSCTGCTLCLSVCPIIDCIRMVDRTAPYVPKRGLVEPV 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(r)	NP_727320.1	PRK11749	55..507	CDD:236967	301/462 (65%)
		Fer4_20	58..170	CDD:291363	96/111 (86%)
		NAD_binding_8	190..>234	CDD:290186	25/43 (58%)
		PRK08318	527..1008	CDD:236237	331/490 (68%)
		DHPD_FMN	527..829	CDD:239244	232/301 (77%)
		Fer4_9	953..997	CDD:289930	34/43 (79%)
dpyda.1	XP_017209335.2	GltD	54..510	CDD:333054	301/459 (66%)
		DHPD_FMN	532..834	CDD:239244	232/301 (77%)
		Fer4_21	947..1005	CDD:317141	46/57 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2769
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D52237at33208
OrthoFinder	1	1.000	-	-		FOG0002090
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920