DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(r) and dpyd

DIOPT Version :9

Sequence 1:	NP_727320.1	Gene:	su(r) / 31858	FlyBaseID:	FBgn0086450	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	XP_002933845.2	Gene:	dpyd / 734021	XenbaseID:	XB-GENE-1000802	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	1026	Identity:	676/1026 - (65%)
Similarity:	798/1026 - (77%)	Gaps:	24/1026 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QLLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTL 69
            ::||:|..|||::|:||||..|..|:..|...|:.|||||||.|.:...|..|.|:|.|||||||
Frog     3 RMLSRDPLDIENILTLNPRTPTHASLYSTAAKKQAKKHWKRNPDRSCSKCEKLENNFDDIKHTTL 67

  Fly    70 SERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPT 134
            .|||||.||.||||||||||||||||.||||||||||||||:|||||||||||||||||||||||
Frog    68 GERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKAIFSDNPLGLTCGMVCPT 132

  Fly   135 SDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQ---AEANP--LSQKIALVGGGP 194
            ||||||||||.|:|.||||||||||||||:||.|.:.|.|.|.   .||.|  ...||||:|.||
Frog   133 SDLCVGGCNLYATEEGPINIGGLQQFATEIFKTMNIPQIRNPSLPATEAMPAQYKTKIALIGAGP 197

  Fly   195 ASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLG 259
            ||:|||:|||||||.|:|::|::.||||||.:||||:|||.|.|:|||:|::||||::..|:.||
Frog   198 ASISCASFLARLGYSDITVFEKQKYLGGLSTSEIPQFRLPYDVVSFEIELMKDLGVKVIEGKGLG 262

  Fly   260 TKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAA 324
            ...:.|:.|...|..|:|:|||||:||::.:|.||...:||||||:|||||:..||.|:|||::.
Frog   263 MNGMNIRSLKEEGFKAIFIGIGLPQPKIDDVFTGLTTEHGFYTSKDFLPLVAKASKQGMCACRSP 327

  Fly   325 AGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPY 389
              ||.:.|.||||||||||||||||||||||||||||||||.:.:||||||||||::|:||.||:
Frog   328 --LPSIKGPVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNMRAVPEEVELAKEEKCEFLPF 390

  Fly   390 LSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPLQ 454
            |||||||:|.|.|:.|||.||||:::..|:|||:|..:|||..|||||||.|.|..|..|:.|::
Frog   391 LSPRKVILKGGKISGMEFVRTEQDDDGNWIEDEDQKIQLKAEVVISAFGSVLTDPAVLEAMKPIK 455

  Fly   455 F-RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQ---GLPLDTPAA 515
            | |..||..|.||||:|...||:|||:||:||||||||||||.|:|.||..:|   |:.:.....
Frog   456 FNRWGLPEADPVTMQTSEAGVFVGGDIAGLANTTVESVNDGKQASWHIHKHIQSLHGVSITNKPE 520

  Fly   516 LPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTN 580
            ||||||.||.|||||||.||:|.|||||||||||||..|||||||.||||.:||||.|:||:|||
Frog   521 LPLFYTPIDLVDISVEMVGIKFPNPFGLASAPPTTSAPMIRRAFEAGWGFALTKTFSLEKDIVTN 585

  Fly   581 VSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDW 645
            |||||:||||||..|||.||.||||||||||.|.||.:||.|||.|||:.|:|||||||:|::||
Frog   586 VSPRIIRGTTSGSIYGPGQGSFLNIELISEKTAAYWCQSITELKADFPKNILIASIMCSYNKDDW 650

  Fly   646 TELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPNIT 710
            ||||:.||.||||||||||||||||||||||||||||||||..|.||||:|||:|||.|||||:|
Frog   651 TELALMAEASGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVKIPFFAKLTPNVT 715

  Fly   711 DIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAISD 775
            |:|.||.||:.|||||.:|.|||.||||||||:|.|||:|:..|||||||||||.||:||:|:|.
Frog   716 DVVKIAMAAQEGGADGVTATNTVSGLMGLKADATPWPAVGRGSRTTYGGVSGNAIRPIALRAVSA 780

  Fly   776 IANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANPP 840
            ||..:||||||..|||||.|..|||:|:||:|||:||:||||||||||||||.||||||||:...
Frog   781 IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAVQNQDFTVIEDYCTGLKALLYLKSIDE 845

  Fly   841 PVDGPFWDGQSPPTPVHQKGKPV---VRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAE 902
            ..|   ||||||||..|||||||   ..:.||   .|..||||..:|...:||.:...   ....
Frog   846 LQD---WDGQSPPTIRHQKGKPVPTIAEIKGE---KLPSFGPYLEKRKRILAENKIND---LTCN 901

  Fly   903 QVKATPPASNGAPN-PAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADS 966
            ....|...::..|| |.|.:|||||.||..||||::|:.::|.|||||::||||||||||||.||
Frog   902 TSPVTKEKTHFVPNKPIPSVKDVIGRALQYIGSYSQLNIQEQVVALIDEEMCINCGKCYMTCNDS 966

  Fly   967 GYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGV 1017
            ||||||||.:||:..|.|.|||||||:|||||||||.||.:..|:|.|||:
Frog   967 GYQAIEFDPETHLTTVTDSCTGCTLCLSVCPIIDCIKMVARTTPYVPKRGL 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(r)	NP_727320.1	PRK11749	55..507	CDD:236967	306/460 (67%)
		Fer4_20	58..170	CDD:291363	98/111 (88%)
		NAD_binding_8	190..>234	CDD:290186	29/43 (67%)
		PRK08318	527..1008	CDD:236237	331/484 (68%)
		DHPD_FMN	527..829	CDD:239244	230/301 (76%)
		Fer4_9	953..997	CDD:289930	34/43 (79%)
dpyd	XP_002933845.2	PRK11749	53..509	CDD:236967	305/457 (67%)
		DHPD_FMN	532..834	CDD:239244	230/301 (76%)
		Fer4_21	946..1004	CDD:373231	46/57 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H85
Inparanoid	1	1.050	1334	1.000	Inparanoid score	I147
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D52237at33208
OrthoFinder	1	1.000	-	-		FOG0002090
OrthoInspector	1	1.000	-	-		oto102765
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1768
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060