back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(r) and dpydb

DIOPT Version :9

Sequence 1:	NP_727320.1	Gene:	su(r) / 31858	FlyBaseID:	FBgn0086450	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	NP_998058.1	Gene:	dpydb / 405829	ZFINID:	ZDB-GENE-040426-2459	Length:	1022	Species:	Danio rerio

Alignment Length:	1022	Identity:	666/1022 - (65%)
Similarity:	785/1022 - (76%)	Gaps:	19/1022 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIKHTTLS 70
            :|||:..|||.:|:||||||:..:|..|...|..|||||||.:.:...|..|.|:|.||||||||
Zfish     4 MLSKELQDIESILALNPRVKSHANVHSTASKKNEKKHWKRNPERSCDSCVNLENNFDDIKHTTLS 68

  Fly    71 ERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVCPTS 135
            |||||.||.||||||||||||||||.||||||||||:|||:|||||||.||||||||||||||||
Zfish    69 ERGALREALRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKAILSDNPLGLTCGMVCPTS 133

  Fly   136 DLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQ---AEANPLS--QKIALVGGGPA 195
            |||||||||.|||.||||||||||||||||.|||:.|.|.|:   |:..|.|  .:|||:|.|||
Zfish   134 DLCVGGCNLYASEEGPINIGGLQQFATEVFSKMGIPQIRNPELPTADNMPKSFHTRIALIGCGPA 198

  Fly   196 SLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLGT 260
            |:|||:|||||||.::||:|::.|:||||.:||||:|||.:.|.|||||::||||::...:.||.
Zfish   199 SISCASFLARLGYDNITIFEKQKYIGGLSTSEIPQFRLPYEVVQFEIDLMKDLGVKVVLEKGLGQ 263

  Fly   261 KDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAAA 325
            ..||:..|...|:..|::|||||:...:.||.||....||||||:|||||:..||.|:|.|::.
Zfish   264 NGLTLTSLKEEGYQVVYIGIGLPQANRDKIFEGLTTEQGFYTSKDFLPLVAKASKIGMCNCRSQ- 327

  Fly   326 GLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPYL 390
             |||||||||||||||||||||||||||||||||||||||.:.|||||||:|.|::|:||.||:|
Zfish   328 -LPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGFTNIRAVPEEMEAAKEEKCEFLPFL 391

  Fly   391 SPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPLQF 455
            ||.:||.|:|.::.:.||||||.::..|:.||||...|||:|:||||||.|.|..|..||.|::.
Zfish   392 SPHEVIKKNGRVSGLRFCRTEQQDDGTWIVDEEQIVHLKADFIISAFGSMLNDPAVTKALDPIKL 456

  Fly   456 -RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQGLPLDTPAA---L 516
             |...|.|:..|||::...||.|||:||.||||||||||||.|:|.||..:|.|..:|.:|   |
Zfish   457 NRWGTPEVNSETMQTTEPWVFAGGDIAGFANTTVESVNDGKQASWHIHKYIQSLHGNTISATPRL 521

  Fly   517 PLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLVTNV 581
            |||:..||.||||||||||:|.|||||||||||||.|||||||||||||.:||||||||||||||
Zfish   522 PLFHCSIDTVDISVEMCGIKFPNPFGLASAPPTTSAAMIRRAFEQGWGFALTKTFGLDKDLVTNV 586

  Fly   582 SPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEEDWT 646
            |||||||||||:.:||.||.||||||||||.|.||.||:.|||.|||:.|:|||||||:|:.|||
Zfish   587 SPRIVRGTTSGHIFGPGQGSFLNIELISEKTAAYWCKSVAELKADFPKNIIIASIMCSYNQADWT 651

  Fly   647 ELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPNITD 711
            |||..|::|.||||||||||||||||||||||||||||||..|.||||||..:|||.|||||:|:
Zfish   652 ELAKMAQESQADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRKATSIPFFAKLTPNVTN 716

  Fly   712 IVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAISDI 776
            ||.||.||..|||||.:|.|||.|||.||||:|.||.||:..|||||||||||.||:||:|:|.|
Zfish   717 IVDIATAAYEGGADGVTATNTVSGLMALKADATPWPGIGRGARTTYGGVSGNAIRPIALRAVSAI 781

  Fly   777 ANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKANPPP 841
            |..:||||||..|||||.|..|||:||||:|||:||:|||||||||||||..||||||||:....
Zfish   782 ARALPGFPILATGGIDSAESGLQFLHAGASVLQVCSAVQNQDFTVIEDYCLGLKALLYLKSIEEL 846

  Fly   842 VDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAEQVKA 906
            .|   ||||||||..|||||||..::.....:|..||||.:.:...:|:.:  |.|..|.  :..
Zfish   847 HD---WDGQSPPTIRHQKGKPVPHVSELIGKSLPSFGPYLQTKTQALAKYK--KDASGDV--IMD 904

  Fly   907 TPPASNGAP-NPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADSGYQA 970
            |..|....| .|.|.:||||..||..||:|.:|||.:|..||:|.:||||||||||||.||||||
Zfish   905 TGAARVNIPKKPIPNVKDVIARALKHIGAYQELDNTEQVQALVDPEMCINCGKCYMTCNDSGYQA 969

  Fly   971 IEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGV 1017
            |:||.:||:|.:.|.|||||||:|||||||||.||.:..|:..|||:
Zfish   970 IKFDPETHLPVITDSCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGL 1016

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.