DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(r) and dpyd-1

DIOPT Version :9

Sequence 1:	NP_727320.1	Gene:	su(r) / 31858	FlyBaseID:	FBgn0086450	Length:	1031	Species:	Drosophila melanogaster
Sequence 2:	NP_508927.2	Gene:	dpyd-1 / 180818	WormBaseID:	WBGene00016103	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	1034	Identity:	651/1034 - (62%)
Similarity:	790/1034 - (76%)	Gaps:	33/1034 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADH-AAPPC--TTLANDFSDIKHT 67
            ||||||||||.||.|||:|:.:.:.||:..||:||.:||||.:. ....|  :.|.|||.|||||
Worm    16 LLSKDSPDIESLLILNPKVQDKANAVPSAVTKKNKHNWKRNEEKGCGSTCGESKLKNDFRDIKHT 80

  Fly    68 TLSERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGMVC 132
            ||||||||:||.|||||||||||||||||||:|||||||:|||:||||:.|.|||||||||||:|
Worm    81 TLSERGALKEAMRCLKCADAPCQKSCPTQLDVKSFITSISNKNYYGAARQILSDNPLGLTCGMIC 145

  Fly   133 PTSDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRTPQAEAN---PLSQKIALVGGGP 194
            ||||||||.|||||||.|.||||||||:|.:|||:|.|||..:.:...|   ...:::||:|.||
Worm   146 PTSDLCVGSCNLQASEEGAINIGGLQQYACDVFKQMNVRQIVSKEVRENRNASHKEQVALIGCGP 210

  Fly   195 ASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETGRSLG 259
            ||:|||:|||||||.|:||||:|:|:||||:|||||:|||.|.|:|||.|.||:||:|||.|.||
Worm   211 ASISCASFLARLGYTDITIYEKRAYIGGLSSAEIPQFRLPYDVVDFEIQLARDIGVQIETNRPLG 275

  Fly   260 TKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCACKAA 324
            ...||:..|...|..|||:|||.||||::|:|.||...||||||||:||.|:..||||:|.||..
Worm   276 KDGLTLAKLKEQGAAAVFIGIGNPEPKIDPLFEGLTIENGFYTSKNYLPAVAAASKPGMCGCKRT 340

  Fly   325 AGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCELLPY 389
            . ||.:.|.|:||||||||.|||||||||||.||.:.||||.:||||||||:|.|::|:||.||:
Worm   341 P-LPTMRGRVVVLGAGDTAMDCATSALRCGASRVTIAFRKGFTGIRAVPEEMEAAKEEKCEFLPF 404

  Fly   390 LSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAALAPLQ 454
            .:|||:.||||.|.::||.:|||::|.:|.|||||...||.::|||||||.|::..|.:||.|.|
Worm   405 SAPRKINVKDGRIVSIEFNKTEQDDNGKWYEDEEQIVILKCDYVISAFGSTLKEDAVLSALQPCQ 469

  Fly   455 FR--GELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQGL----PLDTP 513
            ..  |.:. ||..|.|:|.|.||.|||:||||.||||||||||:|||::|..:|.|    ..:||
Worm   470 LNKWGGIE-VDSTTQQTSEKWVFAGGDVAGVAETTVESVNDGKIAAWNMHRYIQSLHGNQVSETP 533

  Fly   514 AALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKDLV 578
             .||.|:|.||.|||||:|||::|||||||||||||||..|.||||||||||::|||:|||||||
Worm   534 -ELPQFFTPIDEVDISVDMCGVKFENPFGLASAPPTTSGPMCRRAFEQGWGFILTKTYGLDKDLV 597

  Fly   579 TNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFNEE 643
            ||||||||||:|||..|||.||.|:||||||||..||||:.|.|||||.|.|||||||||.:|:.
Worm   598 TNVSPRIVRGSTSGPLYGPNQGSFMNIELISEKSCEYWLQCIRELKRDHPTKIVIASIMCVYNKA 662

  Fly   644 DWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLTPN 708
            ||.|||.|:|::|||.|||||||||||||:||||||||.||:|::|.||||..||:|||.|:|||
Worm   663 DWIELATKSEEAGADILELNLSCPHGMGEKGMGLACGQSPEIVKEICRWVRACVKIPFFPKMTPN 727

  Fly   709 ITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALKAI 773
            |||:..||.||:.|||.|.:|.|||..||.:|||..||||||..:||||||:||:|.||:|:||:
Worm   728 ITDVREIARAARDGGASGVTATNTVSSLMHMKADGNAWPAIGSTKRTTYGGMSGSAIRPIAMKAV 792

  Fly   774 SDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLKAN 838
            |.|||.:.||||:..|||:|.|..|.|:.|||:|||:||:||||||||::||||.|||||||...
Worm   793 SSIANELDGFPIMATGGIESAETGLGFLMAGASVLQVCSAVQNQDFTVVDDYCTGLKALLYLSGA 857

  Fly   839 PPPVDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDAEQ 903
            ....:   |||||||...||||||::.   :|:..:.|||.|:.:|: |:..::..:..|.|.|.
Worm   858 ESLKN---WDGQSPPIEKHQKGKPILL---QGQKKMPFFGKYRDERE-KLEAIKLSESNLLDTEN 915

  Fly   904 VK-ATPPASNGAPNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTCADSG 967
            .. |:.|.:.  .:..|.::||||.||.:||.|..|||::||||:||||||||||||||||.|||
Worm   916 YHFASRPDTQ--VSRVPTVEDVIGKALPRIGPYVTLDNQEQKVAIIDDDMCINCGKCYMTCNDSG 978

  Fly   968 YQAIEFDKDTHIPHV-NDDCTGCTLCVSVCPIIDCITMVPK----KIPHVIKRGVEEKI 1021
            ||||.||..||.||| .|||||||||.|||||.:||.|||:    |.|   ||||:..:
Worm   979 YQAITFDPVTHQPHVTEDDCTGCTLCYSVCPIPECIEMVPRTGPWKAP---KRGVKPSV 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(r)	NP_727320.1	PRK11749	55..507	CDD:236967	295/456 (65%)
		Fer4_20	58..170	CDD:291363	93/111 (84%)
		NAD_binding_8	190..>234	CDD:290186	32/43 (74%)
		PRK08318	527..1008	CDD:236237	312/486 (64%)
		DHPD_FMN	527..829	CDD:239244	214/301 (71%)
		Fer4_9	953..997	CDD:289930	36/44 (82%)
dpyd-1	NP_508927.2	PRK11749	69..523	CDD:236967	295/455 (65%)
		Fer4_20	71..183	CDD:291363	93/111 (84%)
		NAD_binding_8	206..>251	CDD:290186	33/44 (75%)
		PRK08318	546..1019	CDD:236237	311/481 (65%)
		DHPD_FMN	546..848	CDD:239244	214/301 (71%)
		Fer4_9	964..1009	CDD:289930	36/44 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157581
Domainoid	1	1.000	456	1.000	Domainoid score	I246
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H85
Inparanoid	1	1.050	1279	1.000	Inparanoid score	I72
Isobase	1	0.950	-	0	Normalized mean entropy	S1944
OMA	1	1.010	-	-		QHG54589
OrthoDB	1	1.010	-	-		D52237at33208
OrthoFinder	1	1.000	-	-		FOG0002090
OrthoInspector	1	1.000	-	-		oto19144
orthoMCL	1	0.900	-	-		OOG6_100674
Panther	1	1.100	-	-	LDO	PTHR43073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2494
SonicParanoid	1	1.000	-	-		X1768
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890