Protein Alignment su(r) and DPYD

DIOPT Version :10

• Sequence 1: NP_727320.1
• Gene: su(r) / 31858
• FlyBaseID: FBgn0086450
• Length: 1031
• Species: Drosophila melanogaster
• Sequence 2: NP_000101.2
• Gene: DPYD / 1806
• HGNCID: 3012
• Length: 1025
• Species: Homo sapiens
• Alignment Length: 1029
• Identity: 674/1029 - (65%)
• Similarity: 786/1029 - (76%)
• Gaps: 24/1029 - (2%)

  Fly     1 MSPPQLLSKDSPDIEDLLSLNPRVKTQCSVVPTKQTKENKKHWKRNADHAAPPCTTLANDFSDIK 65
            |:|  :|||||.|||.:|:||||.:|..::..|...|.:|||||||.|.....|..|.|:|.|||
Human     1 MAP--VLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIK 63

  Fly    66 HTTLSERGALEEAARCLKCADAPCQKSCPTQLDIKSFITSIANKNFYGAAKAIFSDNPLGLTCGM 130
            ||||.|||||.||.||||||||||||||||.||||||||||||||:|||||.|||||||||||||
Human    64 HTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGM 128

  Fly   131 VCPTSDLCVGGCNLQASEAGPINIGGLQQFATEVFKKMGVRQRRT-----PQAEANPLSQKIALV 190
            ||||||||||||||.|:|.|||||||||||||||||.|.:.|.|.     |:..:...|.||||.
Human   129 VCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALF 193

  Fly   191 GGGPASLSCATFLARLGYRDVTIYERRSYLGGLSAAEIPQYRLPIDAVNFEIDLVRDLGVRIETG 255
            |.||||:|||:|||||||.|:||:|::.|:||||.:||||:|||.|.|||||:|::||||:|..|
Human   194 GAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICG 258

  Fly   256 RSLGTKDLTIQGLLSTGHDAVFVGIGLPEPKLNPIFAGLQPSNGFYTSKNFLPLVSDGSKPGLCA 320
            :||...::|:..|...|:.|.|:|||||||..:.||.||....||||||:|||||:.|||.|:||
Human   259 KSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCA 323

  Fly   321 CKAAAGLPKLHGNVIVLGAGDTAFDCATSALRCGARRVFVVFRKGSSGIRAVPEEVELARDERCE 385
            |.:.  ||.:.|.||||||||||||||||||||||||||:|||||...|||||||:|||::|:||
Human   324 CHSP--LPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCE 386

  Fly   386 LLPYLSPRKVIVKDGLITAMEFCRTEQNENDEWVEDEEQTQRLKANFVISAFGSGLEDQDVKAAL 450
            .||:|||||||||.|.|.||:|.||||:|..:|.|||:|...|||:.|||||||.|.|..||.||
Human   387 FLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEAL 451

  Fly   451 APLQF-RGELPVVDRVTMQSSVKQVFLGGDLAGVANTTVESVNDGKVAAWSIHCQLQ---GLPLD 511
            :|::| |..||.||..|||:|...||.|||:.|:||||||||||||.|:|.||..:|   |..:.
Human   452 SPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVS 516

  Fly   512 TPAALPLFYTDIDAVDISVEMCGIRFENPFGLASAPPTTSTAMIRRAFEQGWGFVVTKTFGLDKD 576
            ....||||||.||.|||||||.|::|.||||||||.|.|||:|||||||.||||.:||||.||||
Human   517 AKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKD 581

  Fly   577 LVTNVSPRIVRGTTSGYKYGPQQGCFLNIELISEKRAEYWLKSIGELKRDFPEKIVIASIMCSFN 641
            :||||||||:||||||..|||.|..||||||||||.|.||.:|:.|||.|||:.|||||||||:|
Human   582 IVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYN 646

  Fly   642 EEDWTELAIKAEQSGADALELNLSCPHGMGERGMGLACGQDPELVEQISRWVRKAVKLPFFIKLT 706
            :.||||||.|:|.||||||||||||||||||||||||||||||||..|.||||:||::|||.|||
Human   647 KNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLT 711

  Fly   707 PNITDIVSIAAAAKRGGADGGSAINTVQGLMGLKADSTAWPAIGKEQRTTYGGVSGNATRPMALK 771
            ||:|||||||.|||.|||:|.:|.|||.||||||:|.|.|||:|..:|||||||||.|.||:||:
Human   712 PNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALR 776

  Fly   772 AISDIANRVPGFPILGIGGIDSGEVALQFIHAGATVLQICSSVQNQDFTVIEDYCTALKALLYLK 836
            |::.||..:||||||..|||||.|..|||:|:||:|||:||::|||||||||||||.||||||||
Human   777 AVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLK 841

  Fly   837 ANPPPVDGPFWDGQSPPTPVHQKGKPVVRLTGEGKATLGFFGPYQRQRDIKMAELRSQKGALWDA 901
            :.....|   ||||||.|..|||||||.|:.......|..||||..||...:||.:.:.     .
Human   842 SIEELQD---WDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRL-----K 898

  Fly   902 EQVKATPPASNGA---PNPAPRIKDVIGAALDKIGSYNKLDNKQQKVALIDDDMCINCGKCYMTC 963
            ||..|..|.....   ..|.|.||||||.||..:|::.:|.|.:|.||:||::||||||||||||
Human   899 EQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTC 963

  Fly   964 ADSGYQAIEFDKDTHIPHVNDDCTGCTLCVSVCPIIDCITMVPKKIPHVIKRGV 1017
            .|||||||:||.:||:|.:.|.|||||||:|||||:|||.||.:..|:..||||
Human   964 NDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGV 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
su(r)	NP_727320.1	PRK11749	55..507	CDD:481254	310/460 (67%)
		DHPD_FMN	527..829	CDD:239244	225/301 (75%)
		NapF	<887..1009	CDD:440760	66/124 (53%)
		Fer4_21	946..1004	CDD:434137	43/57 (75%)
DPYD	NP_000101.2	PRK11749	53..513	CDD:481254	310/461 (67%)
		DHPD_FMN	532..834	CDD:239244	225/301 (75%)
		Fer4_21	946..1004	CDD:434137	43/57 (75%)