DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-D and RAD51C

DIOPT Version :9

Sequence 1:	NP_733200.1	Gene:	spn-D / 318579	FlyBaseID:	FBgn0003482	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_006722064.1	Gene:	RAD51C / 5889	HGNCID:	9820	Length:	377	Species:	Homo sapiens

Alignment Length:	256	Identity:	82/256 - (32%)
Similarity:	125/256 - (48%)	Gaps:	29/256 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EAIERRP-----SVSHENFRIFDKSCWDI----SQSASNKILTGKKALDTHFGGGISLGHLVELI 70
            |.:..:|     |.||       |.|..:    .:.....|:|...|||...|||:.|....|:.
Human    67 ECLTNKPRYAGTSESH-------KKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEIC 124

  Fly    71 GNSGTGKTQMCLQLCLNVQIPKAAGGLEGSALFIDTRQDFHPDRLMGLA------LKL----ERQ 125
            |..|.||||:|:||.::||||:..||:.|.|:||||...|..||::.||      |:|    .:.
Human   125 GAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKG 189

  Fly   126 YAHR--VPEFKAHKMLQKIHYVRCPKLDQLMATVLSCHRHLVDHPDIKLIVIDSLAFTLRM-LED 187
            ..||  :.:|....:|..|:|.||....:|:|.|......|.:|..::|:::|.:||..|. |:|
Human   190 EEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDD 254

  Fly   188 GAHRYEMLLELHESMRRLQRQHELTWVFTNVLTHRYVKQKFQVEPALGDLHSHLINERIWF 248
            .:.|..:|..|.:.|..|...|.|..:.||.:|.:..:.:..:.||||:...|....|:.|
Human   255 LSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIF 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-D	NP_733200.1	P-loop_NTPase	46..249	CDD:304359	75/216 (35%)
RAD51C	XP_006722064.1	HHH_5	12..57	CDD:291205
		recomb_radA	21..349	CDD:131290	82/256 (32%)
		Rad51_DMC1_radA	100..348	CDD:238543	75/216 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157044
Domainoid	1	1.000	117	1.000	Domainoid score	I5907
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4796
Isobase	1	0.950	-	1	Normalized mean entropy	S3735
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1345899at2759
OrthoFinder	1	1.000	-	-		FOG0006918
OrthoInspector	1	1.000	-	-		oto88446
orthoMCL	1	0.900	-	-		OOG6_104543
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4389
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.610