DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-D and Rad51

DIOPT Version :9

Sequence 1:	NP_733200.1	Gene:	spn-D / 318579	FlyBaseID:	FBgn0003482	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_035364.1	Gene:	Rad51 / 19361	MGIID:	97890	Length:	339	Species:	Mus musculus

Alignment Length:	238	Identity:	67/238 - (28%)
Similarity:	105/238 - (44%)	Gaps:	26/238 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KILTGKKALDTHFGGGISLGHLVELIGNSGTGKTQMCLQLCLNVQIPKAAGGLEGSALFIDTRQD 109
            :|.||.|.||....|||..|.:.|:.|...|||||:|..|.:..|:|...||.||.|::|||...
Mouse   101 QITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGT 165

  Fly   110 FHPDRLMGLALKLERQYAHRVPEFKAHKMLQKIHYVRCPKLDQLMATVLSCHRHLVDHPDIKLIV 174
            |.|:||:.:|    .:|.     .....:|..:.|.|....|.....:......:|: ....|::
Mouse   166 FRPERLLAVA----ERYG-----LSGSDVLDNVAYARGFNTDHQTQLLYQASAMMVE-SRYALLI 220

  Fly   175 IDSLAFTLRMLEDGAHRYEM---LLELHESMRRLQRQHELTWVFTNVLTHRYVKQ-----KFQVE 231
            :||.....|  .|.:.|.|:   .:.|...:|.|.|..:...|.. |:|::.|.|     .|..:
Mouse   221 VDSATALYR--TDYSGRGELSARQMHLARFLRMLLRLADEFGVAV-VITNQVVAQVDGAAMFAAD 282

  Fly   232 PAL---GDLHSHLINERIWF-SGSSELHLGKSWRTSRLIKESE 270
            |..   |::.:|....|::. .|..|..:.|.: .|..:.|:|
Mouse   283 PKKPIGGNIIAHASTTRLYLRKGRGETRICKIY-DSPCLPEAE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-D	NP_733200.1	P-loop_NTPase	46..249	CDD:304359	61/214 (29%)
Rad51	NP_035364.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		recomb_RAD51	25..339	CDD:274048	67/238 (28%)
		Interaction with PALB2. /evidence=ECO:0000250	184..257		16/75 (21%)
		Nuclear export signal, masked by the interaction with BRCA2. /evidence=ECO:0000250\|UniProtKB:Q06609	245..260		4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22942
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910