DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spn-D and Dmc1

DIOPT Version :9

Sequence 1:	NP_733200.1	Gene:	spn-D / 318579	FlyBaseID:	FBgn0003482	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_034189.1	Gene:	Dmc1 / 13404	MGIID:	105393	Length:	340	Species:	Mus musculus

Alignment Length:	259	Identity:	67/259 - (25%)
Similarity:	100/259 - (38%)	Gaps:	55/259 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 ERRPSVSHENFRIFDKSCWDISQSASNKILTGKKALDTHFGGGISLGHLVELIGNSGTGKTQMCL 82
            |||..|.|                    |.||.:..|...||||....:.|..|...|||||:..
Mouse    93 ERRKMVFH--------------------ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSH 137

  Fly    83 QLCLNVQIPKAAGGLEGSALFIDTRQDFHPDRLMGLALKLERQYAHRVPEFKAHKMLQKIHYVRC 147
            .||:..|:|...|...|..:||||...|.||||..:|.:....:         ..:|..:.|.|.
Mouse   138 TLCVTAQLPGTGGYSGGKIIFIDTENTFRPDRLRDIADRFNVDH---------EAVLDNVLYARA 193

  Fly   148 PKLDQLMATVLSCHRHLVD------HPD---IKLIVIDSLAFTLRMLEDG----AHRYEMLLELH 199
            ...:..|        .|:|      |.:   .||::|||:....|:...|    |.|.:.|.::.
Mouse   194 YTSEHQM--------ELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQML 250

  Fly   200 ESMRRLQRQHELTWVFTNVLT-HRYVKQKFQVEPAL---GDLHSHLINERIWF-SGSSELHLGK 258
            ..::::..::.:....||.:| .......||.:|..   |.:.:|....||.. .|..||.:.|
Mouse   251 SRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAK 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-D	NP_733200.1	P-loop_NTPase	46..249	CDD:304359	58/220 (26%)
Dmc1	NP_034189.1	recomb_DMC1	24..338	CDD:131292	67/259 (26%)
		HHH_5	25..79	CDD:291205
		Rad51_DMC1_radA	101..336	CDD:238543	62/231 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810