DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spn-D and DMC1

DIOPT Version :9

Sequence 1:	NP_733200.1	Gene:	spn-D / 318579	FlyBaseID:	FBgn0003482	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_011528136.1	Gene:	DMC1 / 11144	HGNCID:	2927	Length:	362	Species:	Homo sapiens

Alignment Length:	283	Identity:	73/283 - (25%)
Similarity:	110/283 - (38%)	Gaps:	64/283 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EAIERRPSVSHENFRIFDKSCWDISQSASNKILTGKKALDTHFGGGISLGHLVELIGNSGTGKTQ 79
            |..|:|..|.|                    |.||.:..|...||||....:.|..|...|||||
Human    90 EYSEKRKMVFH--------------------ITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQ 134

  Fly    80 MCLQLCLNVQIPKAAGGLEGSALFIDTRQDFHPDRLMGLALKLERQYAHRVPEFKAHKMLQKIHY 144
            :...||:..|:|.|.|...|..:||||...|.||||..:|.:....:         ..:|..:.|
Human   135 LSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVDH---------DAVLDNVLY 190

  Fly   145 VRCPKLDQLMATVLSCHRHLVD------HPD---IKLIVIDSLAFTLRMLEDG----AHRYEMLL 196
            .|....:..|        .|:|      |.:   .||::|||:....|:...|    |.|.:.|.
Human   191 ARAYTSEHQM--------ELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLA 247

  Fly   197 ELHESMRRLQRQHELTWVFTNVLT-HRYVKQKFQVEPAL---GDLHSHLINERIWF-SGSSELHL 256
            ::...::::..::.:....||.:| .......||.:|..   |.:.:|....||.. .|..||.:
Human   248 QMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRI 312

  Fly   257 GKSW-RTS--------RLIKESE 270
            .|.: |.|        :.||:.|
Human   313 AKIYDRLSEREQKASVKTIKDPE 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spn-D	NP_733200.1	P-loop_NTPase	46..249	CDD:304359	59/220 (27%)
DMC1	XP_011528136.1	recomb_DMC1	24..329	CDD:131292	70/275 (25%)
		HHH_5	25..79	CDD:291205
		Rad51_DMC1_radA	101..317	CDD:238543	63/232 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0468
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810