DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk31 and Asic4

DIOPT Version :9

Sequence 1:	NP_001097944.1	Gene:	ppk31 / 318575	FlyBaseID:	FBgn0051065	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	100/456 - (21%)
Similarity:	153/456 - (33%)	Gaps:	133/456 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LYLVTFYHTLPFFANVSLSLLNSYLSSSVSFNLDTIYLNWNSTFPAITVCEIYNAERIWDLSDSN 69
            |:::....:|..|...:.||...||:......:|.......:.|||:|:|.| |..|...|||::
  Rat    69 LWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNI-NRFRHSALSDAD 132

  Fly    70 FGVEHDMHVDDFISEIVFYRGVCSSCEDCSR---MRCPSNFTHLVDVFRTKCHQL---LVNCTYL 128
                        |..:....|:.....|..|   :|.|.  ..:||:.....|||   |.:|.:.
  Rat   133 ------------IFHLANLTGLPPKDRDGHRAAGLRYPE--PDMVDILNRTGHQLADMLKSCNFS 183

  Fly   129 NKLFDC-CDQFLPLPTEYGLCFSFNSHQARKVSHLQFTNNRMTGPGHLSFHAAADIQLYVHAPI- 191
            .  ..| ...|..:.|.||.|::||:.....:.      :|..|.|. ......|||...:.||
  Rat   184 G--HHCSASNFSVVYTRYGKCYTFNADPQSSLP------SRAGGMGS-GLEIMLDIQQEEYLPIW 239

  Fly   192 -DVPYQFSEGMIRETVLLGHYKELILNVIEVHNDES---VQDLS-------------MEQR---- 235
             :......|..||               :::|:.|.   :..|.             .|||
  Rat   240 RETNETSFEAGIR---------------VQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYL 289

  Fly   236 -----RCRYGHE-HVPERQGIYDFYSYSGCVVECTVLLQLDNCNCTSHFMAIPGQNYLPVCDVRG 294
                 .||...: ..||.|| |..||.|.|.:.|.....|..|:|  ..:.:||..  .:|....
  Rat   290 PQPWGNCRAESKLREPELQG-YSAYSVSACRLRCEKEAVLQRCHC--RMVHMPGNE--TICPPNI 349

  Fly   295 LI-CLTRIRDKIMTERKS-CECMSSCEEPEYNIIYNSADEDDEASDEVSEIRVALVELP------ 351
            .| |.....|.:....:. |.|.:.|....|             ..|:|     :|::|
  Rat   350 YIECADHTLDSLGGGSEGPCFCPTPCNLTRY-------------GKEIS-----MVKIPNRGSAR 396

  Fly   352 --TQRYVRRVTKTILDFLI--------------------------SLGGLVGLFFNTSALRIVET 388
              .::|.|..|....:||:                          .|||.:|||...|.|.::|.
  Rat   397 YLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEI 461

  Fly   389 I 389
            :
  Rat   462 L 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk31	NP_001097944.1	ASC	<127..387	CDD:279230	67/324 (21%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	100/456 (22%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920