Protein Alignment ppk31 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_001097944.1
• Gene: ppk31 / 318575
• FlyBaseID: FBgn0051065
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 101/526 - (19%)
• Similarity: 164/526 - (31%)
• Gaps: 188/526 - (35%)

  Fly     4 ILYLVTFYHTLPFFANVSLSLLNSYLSSSVSFNLDTIYLNWNS---TFPAITVCEIYNAERIWDL 65
            :|:|.||......|.    .|...|.|..||.|     :|.||   .|||:|:|.: |..|..::
Human   148 VLWLCTFGMMYWQFG----LLFGEYFSYPVSLN-----INLNSDKLVFPAVTICTL-NPYRYPEI 202

  Fly    66 SDSNFGVEHDMHVDDFISEIVFY---------------------------------------RGV 91
            .:..  .|.|...:..:.::..|                                       |.|
Human   203 KEEL--EELDRITEQTLFDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARRARSV 265

  Fly    92 CSSCED----------------CSRMRCP---SNFTHLVDVFRT--KCHQL------------LV 123
            .||..|                |::.:..   ..::..||..|.  :.|.:            |.
Human   266 ASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLE 330

  Fly   124 NCTYLNKLFDC------CDQ------FLPLPTEYGLCFSFNSHQARK--VSHLQFTNNRMTGPGH 174
            ..|..|.:|.|      |:|      ..|:   ||.|::||......  :|.:...||.::
Human   331 EDTLGNFIFACRFNQVSCNQANYSHFHHPM---YGNCYTFNDKNNSNLWMSSMPGINNGLS---- 388

  Fly   175 LSFHA-----------AADIQLYVHAPIDVPYQFSEG-------------MIRETV--LLGHYKE 213
            |...|           ....::.||.. |.|....:|             |.:||:  |.|.|.:
Human   389 LMLRAEQNDFIPLLSTVTGARVMVHGQ-DEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGD 452

  Fly   214 LILNVIEVHNDESVQDLSMEQRRCRYGHEHVPERQGIYDFYSYSGCVVECTVLLQLDNCNCTSHF 278
            ...|    .:|..|::|             .|.:      |:...|:..|.....:..|.|...|
Human   453 CTKN----GSDVPVENL-------------YPSK------YTQQVCIHSCFQESMIKECGCAYIF 494

  Fly   279 MAIPGQNYLPVCDVR-----GLICLTRIRDKIMTERKSC--ECMSSCEEPEYNIIYNSADEDDEA 336
            ...| || :..||.|     | .|..:::....::...|  :|...|....|.:....:......
Human   495 YPRP-QN-VEYCDYRKHSSWG-YCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVT 556

  Fly   337 SDE--------------------VSEIRVALVELPTQRYVRRVTKTILDFLISLGGLVGLFFNTS 381
            |.|                    |:::.:...||..:......:.|::..|.:||....|:|.:|
Human   557 SQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSS 621

  Fly   382 ALRIVE 387
            .|.:||
Human   622 VLSVVE 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk31	NP_001097944.1	ASC	36..387	CDD:459966	89/492 (18%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	101/526 (19%)