DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk31 and ASIC2

DIOPT Version :9

Sequence 1:NP_001097944.1 Gene:ppk31 / 318575 FlyBaseID:FBgn0051065 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_899233.1 Gene:ASIC2 / 40 HGNCID:99 Length:563 Species:Homo sapiens


Alignment Length:468 Identity:107/468 - (22%)
Similarity:166/468 - (35%) Gaps:164/468 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 SLSLLNSYLSSS----VSFNLDT-IYLNWNS--TFPAITVCEIYNAERIWDLSDSN-FGVEH--- 74
            |..||.|:.|:.    :||...| ::..|:.  .|||:|||. .|..|...||..: :...|   
Human    96 SFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCN-NNPLRFPRLSKGDLYYAGHWLG 159

  Fly    75 ----DMHVDDFISEIV--------FYRGVCSSCEDCSRMRCPSNFTHLVDVFRTKC-HQL---LV 123
                :......:||::        ::|.:.    |......|.:|..:...|..:. |||   |:
Human   160 LLLPNRTARPLVSELLRGDEPRRQWFRKLA----DFRLFLPPRHFEGISAAFMDRLGHQLEDMLL 220

  Fly   124 NCTYLNKLFDCC--DQFLPLPTEYGLCFSFNSHQARKVSHLQFTNNRMTGPGHLSFHAAADIQLY 186
            :|.|..:|   |  ..|..:.|:||.|:.|||.:..|  .|..|....||.|   .....|||..
Human   221 SCKYRGEL---CGPHNFSSVFTKYGKCYMFNSGEDGK--PLLTTVKGGTGNG---LEIMLDIQQD 277

  Fly   187 VHAPIDVPYQFSEGMIRETVLLGHYKELILNVIEVHNDES---VQDL-------------SMEQR 235
            .:.||       .|...||......|      :::|:...   :|:|             :.|||
Human   278 EYLPI-------WGETEETTFEAGVK------VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQR 329

  Fly   236 ---------RCRYGHEHVPERQGIYDF---YSYSGCVVECTVLLQLDNCNCTSHFMAIPGQNYLP 288
                     .||      ....|: ||   ||.:.|.::|.....::||||  ..:.:||.  .|
Human   330 LTYLPPPWGECR------SSEMGL-DFFPVYSITACRIDCETRYIVENCNC--RMVHMPGD--AP 383

  Fly   289 VCDVRGLICLTRIRDK--------IMTERKS--CECMSSCEEPEYNIIYNSADEDDEASDEVSEI 343
            .|        |..:.|        ::.|:.|  |.|.:.|....||             .|:|  
Human   384 FC--------TPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYN-------------KELS-- 425

  Fly   344 RVALVELPTQRYVRRVTK-------------TILD---------------------FLISLGGLV 374
               :|::|::...:.:.|             .:||                     .|..:||.:
Human   426 ---MVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487

  Fly   375 GLFFNTSALRIVE 387
            |||...|.|.|:|
Human   488 GLFIGASILTILE 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk31NP_001097944.1 ASC <127..387 CDD:279230 74/333 (22%)
ASIC2NP_899233.1 ENaC 64..547 CDD:273304 107/468 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D303969at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11690
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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