DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk31 and Asic2

DIOPT Version :9

Sequence 1:	NP_001097944.1	Gene:	ppk31 / 318575	FlyBaseID:	FBgn0051065	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	108/468 - (23%)
Similarity:	167/468 - (35%)	Gaps:	164/468 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SLSLLNSYLSSS----VSFNLDT-IYLNWNS--TFPAITVCEIYNAERIWDLSDSN-FGVEH--- 74
            ||.||.|:.|:.    :||...| ::..|:.  .|||:|||. .|..|...||..: :...|
  Rat    96 SLGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCN-NNPLRFPRLSKGDLYYAGHWLG 159

  Fly    75 ----DMHVDDFISEIV--------FYRGVCSSCEDCSRMRCPSNFTHLVDVFRTKC-HQL---LV 123
                :......:||::        ::|.:.    |......|.:|..:...|..:. |||   |:
  Rat   160 LLLPNRTARPLVSELLRGDEPRRQWFRKLA----DFRLFLPPRHFEGISAAFMDRLGHQLEDMLL 220

  Fly   124 NCTYLNKLFDCC--DQFLPLPTEYGLCFSFNSHQARKVSHLQFTNNRMTGPGHLSFHAAADIQLY 186
            :|.|..:|   |  ..|..:.|:||.|:.|||.:..|  .|..|....||.|   .....|||..
  Rat   221 SCKYRGEL---CGPHNFSSVFTKYGKCYMFNSGEDGK--PLLTTVKGGTGNG---LEIMLDIQQD 277

  Fly   187 VHAPIDVPYQFSEGMIRETVLLGHYKELILNVIEVHNDES---VQDL-------------SMEQR 235
            .:.||       .|...||......|      :::|:...   :|:|             :.|||
  Rat   278 EYLPI-------WGETEETTFEAGVK------VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQR 329

  Fly   236 ---------RCRYGHEHVPERQGIYDF---YSYSGCVVECTVLLQLDNCNCTSHFMAIPGQNYLP 288
                     .||      ....|: ||   ||.:.|.::|.....::||||  ..:.:||.  .|
  Rat   330 LTYLPPPWGECR------SSEMGL-DFFPVYSITACRIDCETRYIVENCNC--RMVHMPGD--AP 383

  Fly   289 VCDVRGLICLTRIRDK--------IMTERKS--CECMSSCEEPEYNIIYNSADEDDEASDEVSEI 343
            .|        |..:.|        ::.|:.|  |.|.:.|....||             .|:|
  Rat   384 FC--------TPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYN-------------KELS-- 425

  Fly   344 RVALVELPTQRYVRRVTK-------------TILD---------------------FLISLGGLV 374
               :|::|::...:.:.|             .:||                     .|..:||.:
  Rat   426 ---MVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQM 487

  Fly   375 GLFFNTSALRIVE 387
            |||...|.|.|:|
  Rat   488 GLFIGASLLTILE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk31	NP_001097944.1	ASC	<127..387	CDD:279230	74/333 (22%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	108/468 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020