DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk31 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_001097944.1	Gene:	ppk31 / 318575	FlyBaseID:	FBgn0051065	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_036780.1	Gene:	Scnn1b / 24767	RGDID:	3640	Length:	638	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	114/520 - (21%)
Similarity:	181/520 - (34%)	Gaps:	177/520 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LNSYLSSSVSFNLDTIYLNWNSTFPAITVC---------------EIYN-AERIWD--------- 64
            :.:|||..||.:|...:...|  |||:|||               ::|. .|.:.|
  Rat    71 IQTYLSWEVSVSLSMGFKTMN--FPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSH 133

  Fly    65 ---LSDSNFGV--------------EH----DMHVDDFISEIVFYRGVCSS--CEDCSRMRCPSN 106
               .|..||.:              :|    ::..|...|........|::  |:...|: |.:|
  Rat   134 TNTTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRL-CSAN 197

  Fly   107 FT--------------------HLVDVFRTKCHQLLVNCTY------LNKLF--DCCD--QFLPL 141
            .|                    ...::|.....|.||...|      |..||  :.|.  .|.|:
  Rat   198 GTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPI 262

  Fly   142 --PTEYGLCFSFNSHQARKVSHLQFTNNRMTGPG---------------HLSFHAA-ADIQLYVH 188
              | :||.|:.||.....|.  |...|     ||               ::.|.|: |..:|.:|
  Rat   263 FYP-DYGNCYIFNWGMTEKA--LPSAN-----PGTEFGLKLILDIGQEDYVPFLASTAGARLMLH 319

  Fly   189 APIDVPYQFSEGMI----RET---VLLGH-------YKELILNVIEVHNDESVQDLSMEQRRCRY 239
            .....|:...||:.    .||   |||..       |....:|    .:|.::|:|..:....
  Rat   320 EQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMN----GSDVAIQNLYSDYNTT-- 378

  Fly   240 GHEHVPERQGIYDFYSYSGCVVECTVLLQLDNCNCTSHFMAIP-GQNYLPVCDVRGL----ICLT 299
                          ||...|:..|.....:.||:|..:...:| |:.|   |:.|..    .|..
  Rat   379 --------------YSIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKY---CNNRDFPDWAYCYL 426

  Fly   300 RIRDKIMTERKSC--ECMSSCEEPEYNIIYNSADEDDEAS------------DEVSEI---RVAL 347
            .::..:: :|::|  .|..||.:.:|.:..:.||...|||            |:.|.|   |..:
  Rat   427 SLQMSVV-QRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGI 490

  Fly   348 VELPT--QRYVRRV-----TKTILDFLISLGGLVGLFFNTSALRIVE--TIVICLRYRKTIVKWV 403
            |:|..  |.:..|.     ...|:..|.:|||..|.:...|.|.::|  .|:|...: .|::|.|
  Rat   491 VKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIW-ITVIKLV 554

Fly 404 403
Rat 555 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk31	NP_001097944.1	ASC	<127..387	CDD:279230	76/330 (23%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	114/520 (22%)
		deg-1	29..538	CDD:273309	108/501 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820