DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk31 and Scnn1a

DIOPT Version :10

Sequence 1:NP_001097944.1 Gene:ppk31 / 318575 FlyBaseID:FBgn0051065 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_035454.3 Gene:Scnn1a / 20276 MGIID:101782 Length:699 Species:Mus musculus


Alignment Length:542 Identity:101/542 - (18%)
Similarity:169/542 - (31%) Gaps:188/542 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ILYLVTFYHTLPFFANVSLSLLNSYLSSSVSFNLDTIYLNWNS---TFPAITVCEIYNAERIWDL 65
            :|:|.||......||    .|...|.|..||.|     :|.||   .|||:|||.: |..|..: 
Mouse   114 VLWLCTFGMMYWQFA----LLFEEYFSYPVSLN-----INLNSDKLVFPAVTVCTL-NPYRYTE- 167

  Fly    66 SDSNFGVEHDMHVDDFISEIVFY-----------------------RGVCSSCEDCSRMRCP--- 104
                  ::.|:...|.|:|...:                       ||...  ....|:|.|   
Mouse   168 ------IKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALP--HPLQRLRTPPPP 224

  Fly   105 -------SNFTHLVD----VFRTK-------CHQLLVNCTY---------------------LNK 130
                   |..:.:.|    |.|..       |:|...:|.|                     |::
Mouse   225 NPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSR 289

  Fly   131 L----------------FDC------CDQ------FLPLPTEYGLCFSFNSHQARK--VSHLQFT 165
            |                |.|      |:|      ..|:   ||.|::||:.....  :|.:...
Mouse   290 LPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPM---YGNCYTFNNKNNSNLWMSSMPGV 351

  Fly   166 NNRMTGPGHLSFH-----------AAADIQLYVHAPIDVPYQFSEG--MIRETVLLGHYKELILN 217
            ||.::    |:..           .....::.||.. |.|....:|  .:|..|      |..::
Mouse   352 NNGLS----LTLRTEQNDFIPLLSTVTGARVMVHGQ-DEPAFMDDGGFNVRPGV------ETSIS 405

  Fly   218 VIEVHNDESVQDLSMEQRRCRYGHEHVPERQGIYDFYSYSGCVVECTVLLQLDNCNCTSHFMAIP 282
            :    ..|::..|......|......||.:......|:...|:..|.....:..|.|.  ::..|
Mouse   406 M----RKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCA--YIFYP 464

  Fly   283 GQNYLPVCDVRGL----ICLTRIRDKIMTERKSC--ECMSSCEEPEYNII-----YNSADEDD-- 334
            ....:..||....    .|..:::.....:...|  :|...|....|.:.     :.|....|  
Mouse   465 KPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWI 529

  Fly   335 -------------EASDEVSEIRVALVELPTQRYVRRVTKTILDFLISLGGLVGLFFNTSALRIV 386
                         ...:.|:::.:...||..:......:.|::..|.:||....|:|.:|.|.:|
Mouse   530 FEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVV 594

  Fly   387 E-----------TIVICL-RYR 396
            |           |:::.| |:|
Mouse   595 EMAELIFDLLVITLIMLLHRFR 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk31NP_001097944.1 ASC 36..387 CDD:459966 84/487 (17%)
Scnn1aNP_035454.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71
ENaC 79..676 CDD:273304 101/542 (19%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:18650438 200..270 13/71 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..699
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P37088 669..673
Blue background indicates that the domain is not in the aligned region.

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