DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk31 and Asic1

DIOPT Version :9

Sequence 1:	NP_001097944.1	Gene:	ppk31 / 318575	FlyBaseID:	FBgn0051065	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001276720.1	Gene:	Asic1 / 11419	MGIID:	1194915	Length:	559	Species:	Mus musculus

Alignment Length:	460	Identity:	95/460 - (20%)
Similarity:	158/460 - (34%)	Gaps:	166/460 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VTFYHTLPFFANVSLSLLNSYLSSSVSFNLDTIYLNWNSTFPAITVCEIYNAERIWDLSDSN--- 69
            |.:|.:.|     .::||:...::.:             .|||:|.|.. ||.|:..||..:
Mouse   110 VAYYLSYP-----HVTLLDEVATTEL-------------VFPAVTFCNT-NAVRLSQLSYPDLLY 155

  Fly    70 ----FGVEHDMHVDDFISEIVFYRGVCSSCEDCSRMRCPSNFT----HLVDVFRTKCHQL---LV 123
                .|::..   ||        .||..:...      |..|:    :|...:...||:|   |:
Mouse   156 LAPMLGLDES---DD--------PGVPLAPPG------PEAFSGEPFNLHRFYNRSCHRLEDMLL 203

  Fly   124 NCTYLNKLFDC---C--DQFLPLPTEYGLCFSFNSHQARKVSHLQFTNNRMTGPGHLSFHAAADI 183
            .|:|      |   |  ..|..:.|.||.|::|||.|..: ..|: |....||.|   .....||
Mouse   204 YCSY------CGGPCGPHNFSVVFTRYGKCYTFNSGQDGR-PRLK-TMKGGTGNG---LEIMLDI 257

  Fly   184 QLYVHAPIDVPYQFSEGMIRETVLLGHYKELILNVIEVHNDES---VQDL------------SME 233
            |...:.|:       .|...||......|      :::|:.:.   :..|            |.:
Mouse   258 QQDEYLPV-------WGETDETSFEAGIK------VQIHSQDEPPFIDQLGFGVAPGFQTFVSCQ 309

  Fly   234 QRRCRYGHEHVPERQG----------IYDFYSYSGCVVECTVLLQLDNCNCTSHFMAIPGQNYLP 288
            ::|..|    :|...|          .:|.||.:.|.::|.....::||||  ..:.:||.  .|
Mouse   310 EQRLIY----LPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNC--RMVHMPGD--AP 366

  Fly   289 VCDVRGL-ICLTRIRDKIM-TERKSCECMSSCEEPEYNIIYNSADEDDEASDEVSEIRVALVELP 351
            .|..... .|.....|.:: .:::.|.|...|....|             ..|:|     :|::|
Mouse   367 YCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRY-------------GKELS-----MVKIP 413

  Fly   352 TQRYVRRVTK-------------TILD---------------------FLISLGGLVGLFFNTSA 382
            ::...:.:.|             .:||                     .|..:||.:|||...|.
Mouse   414 SKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASI 478

  Fly   383 LRIVE 387
            |.::|
Mouse   479 LTVLE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk31	NP_001097944.1	ASC	<127..387	CDD:279230	66/325 (20%)
Asic1	NP_001276720.1	ASC	63..541	CDD:295594	95/460 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920