Protein Alignment CG34133 and LAF1

DIOPT Version :10

• Sequence 1: NP_001036772.2
• Gene: CG34133 / 318566
• FlyBaseID: FBgn0083969
• Length: 1108
• Species: Drosophila melanogaster
• Sequence 2: NP_013820.1
• Gene: LAF1 / 855128
• SGDID: S000004708
• Length: 834
• Species: Saccharomyces cerevisiae
• Alignment Length: 692
• Identity: 179/692 - (25%)
• Similarity: 272/692 - (39%)
• Gaps: 206/692 - (29%)

  Fly   585 TSHLEVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRLKKKTARIK----------RFFGST 639
            ||..:|..:.|:..:..|   |.|..:..:|..:.|..|...|..:::.          :|..:.
Yeast     9 TSISKVHSEFSNSSNTTG---SEEESRSHQESFDGESSSGESKSKSKLNLEYSADIEPLKFRMTK 70

  Fly   640 MRKTVDKAK----SIASEVSHARHKEDVA-----------------DIVDAMNPEQNIK----IK 679
            ...|.||.|    ..|:: |..|.||.:.                 :.:|....|..::    ||
Yeast    71 TNNTNDKLKYSNNGNATD-SFMRLKEHLQRGNTLNSNLRVNEFYPFNSIDTEQFENYLREPKYIK 134

  Fly   680 ASSSNKGPYEFTKLQHVQDL-------------SGEDTS-AVWCMKFSSCGRLLATAGQDKVLRI 730
            .....|...:|.:|...|:|             |.|.|| |:|..|||..|:.:||..:|..:||
Yeast   135 MLKRRKNLKQFRRLFLAQELMAYEGETVTSTSKSSEPTSKAIWSTKFSRDGKFMATGSKDGKIRI 199

  Fly   731 WVL-----------------KDAYPFFQDMRNKYNADQKSSPTPSQ--ESLVSQHSAEEAIAMAT 776
            |.:                 |:|..  :.||.|......::|...|  :|...::..:|.:....
Yeast   200 WKVIGSPVERAELDSSAESNKEARA--KSMRIKQQVSSLNNPKEKQFLDSATEKYEEKEKLLNLY 262

  Fly   777 AAEKCTGPFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVT 841
            |.     .|.|.|...|..|..|:||::||||.||||:||||||:|||..||..|..|.|.||||
Yeast   263 AP-----VFHPTPLRLYKEHVQDVLDINWSKNNFILSASMDKTVKLWHPDRKNSLKTFIHPDFVT 322

  Fly   842 AIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFC-QNGQFAVVGSYDGR 905
            .:.|||.|||:|:||.||.|.|||:|.|.:|:.  |.|.| .|||:.... :.|::.::|:::|.
Yeast   323 CVEFHPTDDRFFISGCLDHKCRLWSILDDEVSF--EYDCQ-DLITSVTLSPEEGKYTIIGTFNGY 384

  Fly   906 CIFYNTDQLKYHTQIHV--RSTRGKN------------RIGRKISGIE----PMPGEDKILVTSN 952
            .....|..|...:..||  |.|:.:|            |.|.:::|::    .:....:::||||
Yeast   385 VHILMTRGLTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSN 449

  Fly   953 DSRVRLYDLRDLNLSCKYKGYLNVSSQIKGSFS--HDGKYIIAGSENQCIYIWKTN--------- 1006
            |||:|::||....|....||:.:.|||.|...|  |....::..|::..:|.|:..
Yeast   450 DSRIRIFDLEQRKLLEVLKGFHSGSSQHKAQLSIWHGQPIVVNSSDDHWVYGWRLKSSDRENDQD 514

  Fly  1007 -----------------------------------HDYSKLSSV------RRD---RSDFWEGIK 1027
                                               |.:.||:::      ..|   ::..:....
Yeast   515 EPKRKPKGLARSGSLRSIFSKSMSRSSSQNNEEKPHHHLKLTNLLPLPHHSNDHYIKNTDYISFH 579

  Fly  1028 AHNATVTCAIFAPHPEA---------II-----------------------------------KP 1048
            ||||.|||...|| ||.         :|                                   ..
Yeast   580 AHNAPVTCVSIAP-PETSKTLSLSNDVICELSLEFFQTSDSFDVLSRSNDDGIMSDVESSLGYNS 643

  Fly  1049 EPDEISNEKLAHNQPDPLVEQHKKGCGYVLVSADFNGAIKVF 1090
            :|..|||.......||.:     ...|.:|:|.|..|.|:||
Yeast   644 KPGSISNASATSAIPDVV-----DAIGTILISTDNVGTIRVF 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	9/70 (13%)
		WD40	704..1046	CDD:475233	132/444 (30%)
		WD40 repeat	707..765	CDD:293791	19/76 (25%)
		WD40 repeat	800..834	CDD:293791	22/33 (67%)
		WD40 repeat	841..878	CDD:293791	19/36 (53%)
		WD40 repeat	885..920	CDD:293791	7/35 (20%)
		WD40 repeat	935..975	CDD:293791	14/43 (33%)
		WD40 repeat	978..1003	CDD:293791	7/26 (27%)
		WD40 repeat	1034..1069	CDD:293791	13/78 (17%)
LAF1	NP_013820.1	WD40	<170..506	CDD:441893	118/345 (34%)
		WD40 repeat	176..221	CDD:293791	11/44 (25%)
		WD40 repeat	234..276	CDD:293791	9/46 (20%)
		WD40 repeat	281..315	CDD:293791	22/33 (67%)
		WD40 repeat	322..358	CDD:293791	20/37 (54%)
		WD40 repeat	363..400	CDD:293791	7/36 (19%)
		WD40 repeat	430..472	CDD:293791	14/41 (34%)
		WD40 repeat	480..502	CDD:293791	4/21 (19%)