DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and LAF1

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_013820.1	Gene:	LAF1 / 855128	SGDID:	S000004708	Length:	834	Species:	Saccharomyces cerevisiae

Alignment Length:	692	Identity:	179/692 - (25%)
Similarity:	272/692 - (39%)	Gaps:	206/692 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   585 TSHLEVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRLKKKTARIK----------RFFGST 639
            ||..:|..:.|:..:..|   |.|..:..:|..:.|..|...|..:::.          :|..:.
Yeast     9 TSISKVHSEFSNSSNTTG---SEEESRSHQESFDGESSSGESKSKSKLNLEYSADIEPLKFRMTK 70

  Fly   640 MRKTVDKAK----SIASEVSHARHKEDVA-----------------DIVDAMNPEQNIK----IK 679
            ...|.||.|    ..|:: |..|.||.:.                 :.:|....|..::    ||
Yeast    71 TNNTNDKLKYSNNGNATD-SFMRLKEHLQRGNTLNSNLRVNEFYPFNSIDTEQFENYLREPKYIK 134

  Fly   680 ASSSNKGPYEFTKLQHVQDL-------------SGEDTS-AVWCMKFSSCGRLLATAGQDKVLRI 730
            .....|...:|.:|...|:|             |.|.|| |:|..|||..|:.:||..:|..:||
Yeast   135 MLKRRKNLKQFRRLFLAQELMAYEGETVTSTSKSSEPTSKAIWSTKFSRDGKFMATGSKDGKIRI 199

  Fly   731 WVL-----------------KDAYPFFQDMRNKYNADQKSSPTPSQ--ESLVSQHSAEEAIAMAT 776
            |.:                 |:|..  :.||.|......::|...|  :|...::..:|.:....
Yeast   200 WKVIGSPVERAELDSSAESNKEARA--KSMRIKQQVSSLNNPKEKQFLDSATEKYEEKEKLLNLY 262

  Fly   777 AAEKCTGPFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVT 841
            |.     .|.|.|...|..|..|:||::||||.||||:||||||:|||..||..|..|.|.||||
Yeast   263 AP-----VFHPTPLRLYKEHVQDVLDINWSKNNFILSASMDKTVKLWHPDRKNSLKTFIHPDFVT 322

  Fly   842 AIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFC-QNGQFAVVGSYDGR 905
            .:.|||.|||:|:||.||.|.|||:|.|.:|:.  |.|.| .|||:.... :.|::.::|:::|.
Yeast   323 CVEFHPTDDRFFISGCLDHKCRLWSILDDEVSF--EYDCQ-DLITSVTLSPEEGKYTIIGTFNGY 384

  Fly   906 CIFYNTDQLKYHTQIHV--RSTRGKN------------RIGRKISGIE----PMPGEDKILVTSN 952
            .....|..|...:..||  |.|:.:|            |.|.:::|::    .:....:::||||
Yeast   385 VHILMTRGLTPVSSFHVADRQTQEQNAHVMVTETDSKIRHGPRVTGLQAFRSQLDNSFRLVVTSN 449

  Fly   953 DSRVRLYDLRDLNLSCKYKGYLNVSSQIKGSFS--HDGKYIIAGSENQCIYIWKTN--------- 1006
            |||:|::||....|....||:.:.|||.|...|  |....::..|::..:|.|:..
Yeast   450 DSRIRIFDLEQRKLLEVLKGFHSGSSQHKAQLSIWHGQPIVVNSSDDHWVYGWRLKSSDRENDQD 514

  Fly  1007 -----------------------------------HDYSKLSSV------RRD---RSDFWEGIK 1027
                                               |.:.||:::      ..|   ::..:....
Yeast   515 EPKRKPKGLARSGSLRSIFSKSMSRSSSQNNEEKPHHHLKLTNLLPLPHHSNDHYIKNTDYISFH 579

  Fly  1028 AHNATVTCAIFAPHPEA---------II-----------------------------------KP 1048
            ||||.|||...|| ||.         :|                                   ..
Yeast   580 AHNAPVTCVSIAP-PETSKTLSLSNDVICELSLEFFQTSDSFDVLSRSNDDGIMSDVESSLGYNS 643

  Fly  1049 EPDEISNEKLAHNQPDPLVEQHKKGCGYVLVSADFNGAIKVF 1090
            :|..|||.......||.:     ...|.:|:|.|..|.|:||
Yeast   644 KPGSISNASATSAIPDVV-----DAIGTILISTDNVGTIRVF 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	9/70 (13%)
		WD40	704..1101	CDD:225201	147/525 (28%)
		WD40	704..1046	CDD:295369	132/444 (30%)
		WD40 repeat	707..765	CDD:293791	19/76 (25%)
		WD40 repeat	800..834	CDD:293791	22/33 (67%)
		WD40 repeat	841..878	CDD:293791	19/36 (53%)
		WD40 repeat	885..920	CDD:293791	7/35 (20%)
		WD40 repeat	935..975	CDD:293791	14/43 (33%)
		WD40 repeat	978..1003	CDD:293791	7/26 (27%)
		WD40 repeat	1034..1069	CDD:293791	13/78 (17%)
LAF1	NP_013820.1	WD40	173..506	CDD:421866	116/342 (34%)
		WD40 repeat	176..221	CDD:293791	11/44 (25%)
		WD40 repeat	234..276	CDD:293791	9/46 (20%)
		WD40 repeat	281..315	CDD:293791	22/33 (67%)
		WD40 repeat	322..358	CDD:293791	20/37 (54%)
		WD40 repeat	363..400	CDD:293791	7/36 (19%)
		WD40 repeat	430..472	CDD:293791	14/41 (34%)
		WD40 repeat	480..502	CDD:293791	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		otm46562
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	LDO	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
TreeFam	0	0.000	Not matched by this tool.
	10	9.770