DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and DGR2

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_012801.1	Gene:	DGR2 / 853738	SGDID:	S000001604	Length:	852	Species:	Saccharomyces cerevisiae

Alignment Length:	618	Identity:	145/618 - (23%)
Similarity:	254/618 - (41%)	Gaps:	168/618 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 FGSTMRKTVDKAKSIASEVSHARHKED--VADIVDAMNPEQNIK----IKASSSNKGPYEFTKLQ 694
            :|:.:|||:.: .|:.|...:...:.|  ..|:.|....|..::    ||.....:|..:|.::.
Yeast    81 YGTRLRKTLHR-NSVVSNGYNKLSENDRWYFDLFDRKYFENYLEEPTYIKIFKKKEGLEQFDRMF 144

  Fly   695 HVQDLSGEDT-------------------SAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAYPFF 740
            ..|:|...|.                   :::.|..||..|:.:....:|..|.:|.:.:: |.
Yeast   145 LAQELKIPDVYKSTTYQGEPAVANSELFKNSICCCTFSHDGKYMVIGCKDGSLHLWKVINS-PV- 207

  Fly   741 QDMRNKYNADQKSSPTPSQESL--------VSQHSAEEAIAMATAAEKCTGP----------FMP 787
              .|::....:||.......||        :|.|:...:......:::..||          |..
Yeast   208 --KRSEMGRSEKSVSASRANSLKIQRHLASISSHNGSISSNDLKPSDQFEGPSKQLHLYAPVFYS 270

  Fly   788 KPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRY 852
            ..|..:..|..|:||.:||||.|::::|||||.:|||..||..|..|.|.||||:..|.|.|||:
Yeast   271 DVFRVFMEHALDILDANWSKNGFLITASMDKTAKLWHPERKYSLKTFVHPDFVTSAIFFPNDDRF 335

  Fly   853 FLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFC-QNGQFAVVGSYDGRCIFYNTDQLKY 916
            .::|.||.:.|||:|.|.:|:...:.   ..|||:.... ..|::.::|:::|......|..||:
Yeast   336 IITGCLDHRCRLWSILDNEVSYAFDC---KDLITSLTLSPPGGEYTIIGTFNGYIYVLLTHGLKF 397

  Fly   917 HTQIHV--RSTRG--KNRI-----------GRKISGIEPMPGE-DK---ILVTSNDSRVRLYDLR 962
            .:..||  :||:|  ||..           |.:|:|::....: ||   ::||:|||:::::||.
Yeast   398 VSSFHVSDKSTQGTTKNSFHPSSEYGKVQHGPRITGLQCFFSKVDKNLRLIVTTNDSKIQIFDLN 462

  Fly   963 DLNLSCKYKGYLNVSSQIKGSF--SHDGKYIIAGSENQCIYIWK--------------------- 1004
            :......:||:.:.||:.:|.|  ..:...:..||::...|.||
Yeast   463 EKKPLELFKGFQSGSSRHRGQFLMMKNEPVVFTGSDDHWFYTWKMQSFNLSAEMNCTAPHRKKRL 527

  Fly  1005 ------------------------------TNHDYSKLS-SVRRDRSDFWEGIK--------AHN 1030
                                          ::|.::..| :|.:.::...:.||        |||
Yeast   528 SGSMSLKGLLRIVSNKSTNDECLTETSNQSSSHTFTNSSKNVLQTQTVGSQAIKNNHYISFHAHN 592

  Fly  1031 ATVTCAIFAPHPEAIIKPEPDEISNE---------------------KLAHNQPD-PLVE----- 1068
            :.||||..|  |:..||..  .:||:                     :...|:|: |:.|
Yeast   593 SPVTCASIA--PDVAIKNL--SLSNDLIFELTSQYFKEMGQNYSESKETCDNKPNHPVTETGGFS 653

  Fly  1069 ----QHKKGCGYVLVSADFNGAIKVFINKTKPK 1097
                ......|.:|::.|..|.|:||.....|:
Yeast   654 SNLSNVVNNVGTILITTDSQGLIRVFRTDILPE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	8/40 (20%)
		WD40	704..1101	CDD:225201	128/544 (24%)
		WD40	704..1046	CDD:295369	112/460 (24%)
		WD40 repeat	707..765	CDD:293791	13/65 (20%)
		WD40 repeat	800..834	CDD:293791	18/33 (55%)
		WD40 repeat	841..878	CDD:293791	15/36 (42%)
		WD40 repeat	885..920	CDD:293791	8/35 (23%)
		WD40 repeat	935..975	CDD:293791	13/43 (30%)
		WD40 repeat	978..1003	CDD:293791	6/26 (23%)
		WD40 repeat	1034..1069	CDD:293791	13/65 (20%)
DGR2	NP_012801.1	WD40	173..506	CDD:421866	96/339 (28%)
		WD40 repeat	176..238	CDD:293791	13/65 (20%)
		WD40 repeat	244..278	CDD:293791	4/33 (12%)
		WD40 repeat	283..317	CDD:293791	18/33 (55%)
		WD40 repeat	324..360	CDD:293791	15/35 (43%)
		WD40 repeat	365..414	CDD:293791	13/48 (27%)
		WD40 repeat	422..476	CDD:293791	14/53 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346501
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		otm46562
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
TreeFam	0	0.000	Not matched by this tool.
	10	9.770