DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and TUP1

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_010007.1	Gene:	TUP1 / 850445	SGDID:	S000000680	Length:	713	Species:	Saccharomyces cerevisiae

Alignment Length:	888	Identity:	177/888 - (19%)
Similarity:	295/888 - (33%)	Gaps:	323/888 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 LASLNAQQQKQQAQQ-------QQQAQPTSSTSSNT-----PPSVGNTSSGMSTPRVSPKHQQSG 234
            :|||..|||:||.||       |||.|..::.|::.     ||:   |:|..:||
Yeast    91 IASLTVQQQRQQQQQQQVQQHLQQQQQQLAAASASVPVAQQPPA---TTSATATP---------- 142

  Fly   235 KEVAATTTGIPSA--ASSAQSSGVGSMVLQEPDVIASTKLAQSKTTDSITSSGPVAPPRRKKKSR 297
              .|.||||.|||  ..:::.:.|||   |.|                 |::.||
Yeast   143 --AANTTTGSPSAFPVQASRPNLVGS---QLP-----------------TTTLPV---------- 175

  Fly   298 NCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFESSLNNATSSASNITLTCSS 362
               :||:.|..||                    ||:|:...:.:.:.....:.:..|
Yeast   176 ---VSSNAQQQLP--------------------QQQLQQQQLQQQQPPPQVSVAPLS-------- 209

  Fly   363 TNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSSTSVHSKPSPSNSAKSN- 426
             ||.::.| .||..:::|||              :..|:        ||...::|..:|::|.|
Yeast   210 -NTAINGS-PTSKETTTLPS--------------VKAPE--------STLKETEPENNNTSKIND 250

  Fly   427 ---SAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLA 488
               :..|..::....:             :||::|.:..|                 |.::....
Yeast   251 TGSATTATTTTATETE-------------IKPKEEDATPA-----------------SLHQDHYL 285

  Fly   489 GTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKN 553
            ...:.....|...|.|...::      |....|.||             ||..|:.||
Yeast   286 VPYNQRANHSKPIPPFLLDLD------SQSVPDALK-------------KQTNDYYIL------- 324

  Fly   554 LDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVI--QKESDEESVIGIPPSIEGQQPDEEE 616
                        .:|.:|   ..:.:.:.|...|..|:  .|.|::...:.     .|.....:.
Yeast   325 ------------YNPALP---REIDVELHKSLDHTSVVCCVKFSNDGEYLA-----TGCNKTTQV 369

  Fly   617 LETEDGS---RLKKKTA------------RIKRFFGSTMRKTVDKAKSIASEVSHARHKEDVADI 666
            ....|||   ||...:|            .......:||..|.....:..:..|.|...:||.::
Yeast   370 YRVSDGSLVARLSDDSAANNHRNSITENNTTTSTDNNTMTTTTTTTITTTAMTSAAELAKDVENL 434

  Fly   667 VDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIW 731
            ..:.:|..::.|::                             :.||..|:.|||..:|:::|||
Yeast   435 NTSSSPSSDLYIRS-----------------------------VCFSPDGKFLATGAEDRLIRIW 470

  Fly   732 VLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATAAEKCTGPFMPKPFCTYNGH 796
                      |:.|:                                         |......||
Yeast   471 ----------DIENR-----------------------------------------KIVMILQGH 484

  Fly   797 TSDLLDVSWSKNYF-----ILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRYFLSG 856
            ..|:    :|.:||     ::|.|.|:|||:|.:...:|.......|.||.:|..|.|.:|..:|
Yeast   485 EQDI----YSLDYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAG 545

  Fly   857 SLDGKLRLWNIPDKKVA-LWNEVD-------GQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQ 913
            |||..:|:|   |.:.. |...:|       |....:.:..|.::||..|.||.|.....:|...
Yeast   546 SLDRAVRVW---DSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSGSLDRSVKLWNLQN 607

  Fly   914 L--KYHTQIHVRSTRGKNRIGRK--ISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYL 974
            .  |..::.....|.....||.|  :..:.....::.||..|.|..|..:|.:..|.....:|:.
Yeast   608 ANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYILSGSKDRGVLFWDKKSGNPLLMLQGHR 672

  Fly   975 N--VSSQIKGSFSHDGKY-IIAGSENQC-IYIWKTNHDYSKLS 1013
            |  :|..:........:| :.|.....| ..|||    |.|::
Yeast   673 NSVISVAVANGSPLGPEYNVFATGSGDCKARIWK----YKKIA 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	3/36 (8%)
		WD40	704..1101	CDD:225201	75/331 (23%)
		WD40	704..1046	CDD:295369	75/331 (23%)
		WD40 repeat	707..765	CDD:293791	12/57 (21%)
		WD40 repeat	800..834	CDD:293791	11/38 (29%)
		WD40 repeat	841..878	CDD:293791	13/37 (35%)
		WD40 repeat	885..920	CDD:293791	9/36 (25%)
		WD40 repeat	935..975	CDD:293791	8/39 (21%)
		WD40 repeat	978..1003	CDD:293791	3/26 (12%)
		WD40 repeat	1034..1069	CDD:293791
TUP1	NP_010007.1	Tup_N	11..88	CDD:400755
		WD40	343..706	CDD:238121	91/454 (20%)
		WD40 repeat	347..383	CDD:293791	8/40 (20%)
		WD40 repeat	394..438	CDD:293791	7/43 (16%)
		WD40 repeat	447..483	CDD:293791	13/115 (11%)
		WD40 repeat	488..523	CDD:293791	11/38 (29%)
		WD40 repeat	530..566	CDD:293791	13/38 (34%)
		WD40 repeat	579..627	CDD:293791	10/47 (21%)
		WD40 repeat	633..669	CDD:293791	7/35 (20%)
		WD40 repeat	675..705	CDD:293791	4/29 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I1430
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960