DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34133 and AT5G54200

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_200231.1	Gene:	AT5G54200 / 835508	AraportID:	AT5G54200	Length:	825	Species:	Arabidopsis thaliana

Alignment Length:	803	Identity:	216/803 - (26%)
Similarity:	361/803 - (44%)	Gaps:	177/803 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 RDDFVME-------FESSLNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHM---- 388
            ::|.|.|       |..||:...||.|     ||::|:...:..:.|.:... |:...:.|
plant    21 KEDKVEEEDNNDDCFYESLDRVLSSCS-----CSTSNSDYDSDPNVSDSIHD-PTPFPVPMFTSG 79

  Fly   389 ----RPMVASVTIAGPKLTQSLGSS-------STSVHSKPSPSNSAKSNSAPARVSSIDPNQGLN 442
                :....||:....:|.:.||.|       ::.:.|:...::|..|.|.|:.|.:.:.:....
plant    80 FELWKSEPESVSERRIRLLRGLGLSNEPDLPPASQLRSRSRRNSSHFSRSVPSDVLTSNHHGKCV 144

  Fly   443 LFKAIQGGYVVKPRDEASNKAQGP--SQDEIERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFY 505
            |...:.|      .|....:..|.  ..|.::.|.|..||.:                      .
plant   145 LRSDVSG------TDNVDREYTGSRMRNDGVDFISKEPMERS----------------------L 181

  Fly   506 RGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLDTGENMPLSEMRSPPV 570
            |.:.:||.    |.:.||::                     :...::|||||....::|:|...:
plant   182 RDIVEKEN----GRDVVLEE---------------------QMCTIRNLDTGREFVVNEVREDGM 221

  Fly   571 PEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPP---------SIEGQQPDEEELETE-DGSRL 625
            .|       .:.::.:..::..:|.  |..:|..|         ::|....|..:|:|. .|||:
plant   222 LE-------RLKEVGTDRQLTLEEF--EICVGTSPIVLELMRRQNVEDVCKDSVDLDTNVSGSRV 277

  Fly   626 KKKTARIKRFFGSTMRKTVDKAKSIASEVSHARHKEDVAD-----------IVDAMNPEQNI--- 676
            .|...|     ||.::    ..|::||.|:..:.:....|           ...|.:..:::
plant   278 TKHRRR-----GSWLK----SIKNVASSVTGYKERRSTDDRDSPSERGGQRFSSATDDSRDMSFH 333

  Fly   677 ---KIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAYP 738
               ::|.....|...|.|.|...|::.....| :|.:|||..||.||:||:|.|::||.:.::
plant   334 DPERVKVRQYGKSCKELTALFKSQEIQAHKGS-IWSIKFSLDGRYLASAGEDCVIQIWKVVES-- 395

  Fly   739 FFQDMRNKYNADQKS-----------------SPTPSQESLVSQHSAEEAIAMATAAEKCTGPFM 786
              :......:.|::.                 |.:|.:....|......::......|...| ..
plant   396 --ERKGELLSMDKQEDGSINLFLLANGSPEPVSMSPKRRGRTSFSRKSVSLDNVLVPEAVFG-LS 457

  Fly   787 PKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDR 851
            .||.|::.||..|:||:||||:..:||||||||||||.:|.|.||..|.|.|:||.|.|:|.||.
plant   458 EKPVCSFVGHLDDVLDLSWSKSQHLLSSSMDKTVRLWDLSSKTCLKVFSHSDYVTCIQFNPVDDN 522

  Fly   852 YFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNT--DQL 914
            ||:|||||.|:|:|:|||.:|..||::.   :::|||.:..:||.|:||||.|.|..|||  ::|
plant   523 YFISGSLDAKVRIWSIPDHQVVDWNDLH---EMVTAACYTPDGQGALVGSYKGTCCLYNTHDNKL 584

  Fly   915 KYHTQIHVRSTRGKNRIGRKISGIEPMPG-EDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSS 978
            :...:|:::: |.|....:||:|.:.:.| ..::||||.|||.|:.|  .::|..|:||:.|.:|
plant   585 QQRREINLKN-RKKKTHHKKITGFQFVAGSSSEVLVTSADSRTRVVD--GVDLVHKFKGFRNTNS 646

  Fly   979 QIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAI--FAPH 1041
            ||..|.:.:||::::.||:..:|:|  |:|    |..|..||        ...|||.:.  |...
plant   647 QISASLTSNGKFLVSASEDSNVYVW--NYD----SDSRAGRS--------KRVTVTNSYENFYCR 697

  Fly  1042 PEAIIKPEPDEISNEKLAHNQPD 1064
            ..::..|.|.:|||.. .:|.|:
plant   698 DVSVAAPWPGKISNNH-TNNSPE 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	8/53 (15%)
		WD40	704..1101	CDD:225201	139/383 (36%)
		WD40	704..1046	CDD:295369	132/363 (36%)
		WD40 repeat	707..765	CDD:293791	17/74 (23%)
		WD40 repeat	800..834	CDD:293791	22/33 (67%)
		WD40 repeat	841..878	CDD:293791	22/36 (61%)
		WD40 repeat	885..920	CDD:293791	16/36 (44%)
		WD40 repeat	935..975	CDD:293791	16/40 (40%)
		WD40 repeat	978..1003	CDD:293791	9/24 (38%)
		WD40 repeat	1034..1069	CDD:293791	9/33 (27%)
AT5G54200	NP_200231.1	WD40	356..672	CDD:421866	123/329 (37%)
		WD40 repeat	366..404	CDD:293791	14/41 (34%)
		WD40 repeat	410..466	CDD:293791	8/56 (14%)
		WD40 repeat	471..505	CDD:293791	22/33 (67%)
		WD40 repeat	512..548	CDD:293791	21/35 (60%)
		WD40 repeat	553..639	CDD:293791	34/88 (39%)
		WD40 repeat	647..673	CDD:293791	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I1203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		otm2463
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830