DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and AT5G42010

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001318727.1	Gene:	AT5G42010 / 834206	AraportID:	AT5G42010	Length:	709	Species:	Arabidopsis thaliana

Alignment Length:	861	Identity:	215/861 - (24%)
Similarity:	348/861 - (40%)	Gaps:	239/861 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 DNEDTDSDTR-SVKSVQGLQQKLRDDFVMEFESSLNNATSSASNITLTCSSTNTVVSASASTSAA 376
            :.||..||.| .|.||.....::.||||        .||......|
plant     8 EEEDWFSDAREEVSSVSDCNSEVADDFV--------QATGDLDLWT------------------- 45

  Fly   377 SSSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSSTSVHSKPSPSNSAKSNSAPARVSSIDPNQGL 441
                       |.|  .|||....|..||:|.|                      ....|.:..|
plant    46 -----------MNP--ESVTNRRQKFFQSMGFS----------------------FKKRDFDLDL 75

  Fly   442 NLFKAIQGGYVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLAGTGSNSLGSSTRYPGF-Y 505
            :|.......::  |..:..........:|.|:.||:|   .|....:|:..:|..:::....| :
plant    76 DLLGDSSSDHI--PVSKQLTSVSETDHEEEEKEEKLL---RNESTSSGSSVSSFSTASLAEAFSF 135

  Fly   506 RGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLDT-GE--NMPLSEMRS 567
            || :.:.|.|:..|:.:|        ||..|....:..|.|.:......|: |:  |.|:|....
plant   136 RG-SFQNRAKNIDDQILL--------TRDYSSNSSSIAEGLSESDSSRFDSYGDLPNSPMSRYEE 191

  Fly   568 PPV--PEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRLKKKTA 630
            .|.  .:||    |..|.:.:|  |:.|..                      |..||...:
plant   192 SPKKGAKGW----LKKLGVLTH--VLDKTE----------------------ECTDGESTR---- 224

  Fly   631 RIKRFFGSTMRKTVDKAKSIASEVSHARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQH 695
                   |::|:.:.:.:|...:..                                 |.:.|..
plant   225 -------SSIRRQLTRVQSFKKQFK---------------------------------ELSSLCV 249

  Fly   696 VQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIW-VLKDAYPFFQDMRNKYNADQKSSP---- 755
            .|:.|..|.|.| .||||..|:.||:||:|.|:|:| :::|     :...|::...:..|.
plant   250 GQEFSAHDGSIV-VMKFSHDGKYLASAGEDCVVRVWNIIED-----ERRDNEFEVAESDSSCVYF 308

  Fly   756 ---TPSQ-ESLVSQH-SAEEAIAMATAAEKCTGPFMPK--------PFCTYNGHTSDLLDVSWSK 807
               ..|| |.|.::: ..|::..:.....:.|...:|.        |...:.|||.::||:|||:
plant   309 GMNDKSQIEPLKTENEKIEKSRGLLRKKSESTCAVLPSKVFSISETPQHEFRGHTGEILDLSWSE 373

  Fly   808 NYFILSSSMDKTVRLWHI-SRKECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKK 871
            ..|:||||:|:|||||.: |..||:..|.|..|||.:||:|.||.||:|||:|||:|:|::...:
plant   374 KGFLLSSSVDETVRLWRVGSSDECIRVFSHKSFVTCVAFNPVDDNYFISGSIDGKVRIWDVSQFR 438

  Fly   872 VALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNT--DQLKYHTQIHVRSTRGKNRI-GR 933
            |..:.::   .:::||..:..:|:.|||||..|.|.||:|  :||:....|   |..||.:: .:
plant   439 VVDYTDI---RQIVTALCYRPDGKGAVVGSMTGECRFYHTTDNQLQLDRDI---SLHGKKKVPNK 497

  Fly   934 KISGIEPMPGE-DKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIK----GSFSHDGKYIIA 993
            :|:|.:..||: ||::|||.||::|:  :..::..||.|...::.:.:.    .||:.|||:|::
plant   498 RITGFQFFPGDSDKVMVTSADSQIRI--ICGVDTICKLKKASSLRTTLMSPTFASFTSDGKHIVS 560

  Fly   994 GSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAIFAPHPE-AIIK---------P 1048
            ..|...|::|..:....|.||.:......:||..:.|.:|.........| :||.         |
plant   561 TIEESGIHVWDFSQPNKKASSQKPKTIRSYEGFLSRNVSVAIPWLGQGKEDSIIADLEKSFAHFP 625

  Fly  1049 EP-DEISNEKLAHNQPD---------------------------PLVEQHKKGC-----GYVLVS 1080
            .| |..|..|.|...|:                           ..|.|:..|.     |.|:|:
plant   626 VPLDYFSPMKGATTWPEEKLGVVAGTAAAAVSATVSSRSKLRLLKSVCQNVHGSTPHLWGLVIVT 690

  Fly  1081 ADFNGAIKVFINKTKP 1096
            |.::|:|:||.|...|
plant   691 ATWDGSIRVFHNYGLP 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	3/36 (8%)
		WD40	704..1101	CDD:225201	142/463 (31%)
		WD40	704..1046	CDD:295369	120/369 (33%)
		WD40 repeat	707..765	CDD:293791	21/66 (32%)
		WD40 repeat	800..834	CDD:293791	19/34 (56%)
		WD40 repeat	841..878	CDD:293791	17/36 (47%)
		WD40 repeat	885..920	CDD:293791	15/36 (42%)
		WD40 repeat	935..975	CDD:293791	15/40 (38%)
		WD40 repeat	978..1003	CDD:293791	8/28 (29%)
		WD40 repeat	1034..1069	CDD:293791	11/72 (15%)
AT5G42010	NP_001318727.1	WD40	251..523	CDD:421866	102/283 (36%)
		WD40 repeat	261..298	CDD:293791	16/42 (38%)
		WD40 repeat	303..360	CDD:293791	9/56 (16%)
		WD40 repeat	367..402	CDD:293791	19/34 (56%)
		WD40 repeat	407..441	CDD:293791	18/33 (55%)
		WD40 repeat	449..489	CDD:293791	17/42 (40%)
		WD40 repeat	499..524	CDD:293791	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I1203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970