DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and AT5G24320

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_197820.2	Gene:	AT5G24320 / 832502	AraportID:	AT5G24320	Length:	698	Species:	Arabidopsis thaliana

Alignment Length:	819	Identity:	201/819 - (24%)
Similarity:	331/819 - (40%)	Gaps:	235/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 ASASTSAASSSLPSTIAIHMRPMVASVTIAGP--------KLTQSLGSSSTSVHSKPSPSNSAKS 425
            ||.|:.....| ||:|:...|   ..|.|..|        |..:.:|.|||        .|.:||
plant    21 ASCSSPCKIES-PSSISGEFR---YDVWIKSPGNTEERREKFLKWMGLSST--------VNESKS 73

  Fly   426 NSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLAGT 490
            .:.....||:  |:...|..       :|..|:..:.::..|....|.:::::.||..:.:
plant    74 GNVYRLSSSV--NESAVLMS-------LKSDDDEFSSSRCDSFSPSESVDRVVNESLCKEE---- 125

  Fly   491 GSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLD 555
            |....|...|..||                                                 :|
plant   126 GEVDSGMVLRNLGF-------------------------------------------------VD 141

  Fly   556 TGE-NMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPPSIEGQQPD----EE 615
            .|: :..|..:.|.||.                 :.|.||..|..::          ||    ||
plant   142 DGDISSSLCSLSSSPVS-----------------DKIVKEHGEPKLL----------PDPMVAEE 179

  Fly   616 ELETEDGSRLKKKTARIKRFFGSTMRKTVDKAKSIASEVSHARHKEDVADIVDAMNPEQNIKIKA 680
            |.|.   |.:.|   |:|..:.|.:.|..:|..        |...::..::....:..:.:|:|
plant   180 EREV---SGIMK---RVKEKWLSRLYKVRNKRS--------AGGDDNGGEVAVCGSRIERVKVK- 229

  Fly   681 SSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIW-VLKDAYPFFQDMR 744
             ...|...|.:.|...|::...: .|:..||||..||.||:||:|.|||:| |::|.
plant   230 -EYKKEAKELSALFKGQEIQAHE-GAILAMKFSPDGRYLASAGEDGVLRVWSVVEDE-------- 284

  Fly   745 NKYNADQKSSPTPSQESLVSQHS-AEEAIAMATAAEKCTGPFM---------------------P 787
               ..::...|......:..:.| ..|...:|...:..||..|                     .
plant   285 ---RCEEHDVPKIDPSCIYFEVSKLSELRPVAVEKDGITGSLMSPRKTTESACVIIPPKIFRVLD 346

  Fly   788 KPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRY 852
            ||...:.||:.|:||:|||||..:||:|:|.:||||.|..::||..|.|.::||::.|:|.||.:
plant   347 KPLHEFLGHSGDILDISWSKNNRLLSASVDNSVRLWQIGCEDCLGIFSHNNYVTSVQFNPVDDDH 411

  Fly   853 FLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTD----Q 913
            |:|||:|||:|:|:....:|..|.:..|   ::||..:..:||..::|:....|.|||..    |
plant   412 FISGSIDGKVRIWSASQCQVVDWADARG---IVTAVCYQPDGQAVIIGTLTSDCRFYNVSGHCLQ 473

  Fly   914 LKYHTQIHVRSTRGKNRIGRKISGIEPMPGED-----KILVTSNDSRVRLYDLRDLNLSCKYKGY 973
            |..|..:|.:    |....::|.|.:.:...|     :::|.|.||:||:...|  |:..||||.
plant   474 LDGHICLHNK----KKSSNKRIIGFQFLLQFDSTDPSRVMVASADSQVRIISGR--NVVHKYKGS 532

  Fly   974 LNVSSQIKGSFSHDGKYIIAGSENQCIYIWK-TNHD--------YS-----KLSSVRRDRSDF-- 1022
            .|..:||..||:.|||:|::..::..:|:|. ..||        :|     |:.|..:..:|.
plant   533 RNAGNQISASFTADGKHIVSACDDSSVYVWNCVGHDPEQSSPGFFSHTKRLKIRSFEKFSADVSV 597

  Fly  1023 ---WEG---IKAHNATVTCAIFAPHPEAIIK--------PEPDEISNEKLAHN-QPDPLVEQ-HK 1071
               |.|   :.:..:.::.::|:...|.::.        ||      ||||.: .|...:.: |.
plant   598 AIPWCGFTPVLSGGSELSPSLFSLGREYVLDSPKGSATWPE------EKLASSFSPVKAIRRSHY 656

  Fly  1072 K----GC----------GYVLVSADFNGAIKVFINKTKP 1096
            |    .|          |.|:|:..::|.||:|.|...|
plant   657 KFLRSSCRRTSESSHLWGLVIVTGGWDGRIKLFHNYGLP 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	6/36 (17%)
		WD40	704..1101	CDD:225201	137/471 (29%)
		WD40	704..1046	CDD:295369	118/395 (30%)
		WD40 repeat	707..765	CDD:293791	18/58 (31%)
		WD40 repeat	800..834	CDD:293791	18/33 (55%)
		WD40 repeat	841..878	CDD:293791	16/36 (44%)
		WD40 repeat	885..920	CDD:293791	12/38 (32%)
		WD40 repeat	935..975	CDD:293791	15/44 (34%)
		WD40 repeat	978..1003	CDD:293791	9/24 (38%)
		WD40 repeat	1034..1069	CDD:293791	9/43 (21%)
AT5G24320	NP_197820.2	WD40	242..629	CDD:225201	119/407 (29%)
		WD40	245..563	CDD:295369	108/338 (32%)
		WD40 repeat	254..314	CDD:293791	20/70 (29%)
		WD40 repeat	320..354	CDD:293791	5/33 (15%)
		WD40 repeat	359..393	CDD:293791	18/33 (55%)
		WD40 repeat	400..436	CDD:293791	16/35 (46%)
		WD40 repeat	441..475	CDD:293791	10/33 (30%)
		WD40 repeat	495..531	CDD:293791	11/37 (30%)
		WD40 repeat	538..562	CDD:293791	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3662
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I1203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970