DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and AT5G02430

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_195863.1	Gene:	AT5G02430 / 831780	AraportID:	AT5G02430	Length:	905	Species:	Arabidopsis thaliana

Alignment Length:	800	Identity:	200/800 - (25%)
Similarity:	345/800 - (43%)	Gaps:	131/800 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 KLRDDFVMEFESSLNNATSSASNITLTCSS-------TNTVVSASASTSAAS------------- 377
            :..||....|:||  |..|:.....|..||       .:..:|.|::.|::|
plant    26 EFEDDDDHFFDSS--NRISTVVPSDLASSSDEEEGEFDDCRISFSSNVSSSSRAAPAPDMSPDYD 88

  Fly   378 --SSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSSTSVHSKPSPSNSAKSNS--APARVSSIDPN 438
              .|.|.:|....|.::..:.:...|  ..||:.|....|:|..:....|.|  |..:|...|.|
plant    89 IWMSAPGSITERRRRLLNGMGLESKK--TRLGAISIQRVSEPVAATGECSGSRVAEVKVEESDHN 151

  Fly   439 QGLNLFKAIQGG-----YVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLAGTGSNSLGSS 498
            ..:|  :.::..     .:|:.|.::..:|   |..|.:|.|:||.:: ::.:|..|.|......
plant   152 SPVN--QRVRRSPSMSVLLVRSRSDSDIEA---SSAEKQRKEEMLGKT-SKSRLTRTASAIGAPC 210

  Fly   499 TRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLDTGENMPLS 563
            .|...::............|......|.:..:.:...|..:.:.|.:     :||||||:...:.
plant   211 ARICPYFTQTQASPPDAPNGHHQSQGQRSGPLLSSVVSNTRFSAFFL-----IKNLDTGKEFIVK 270

  Fly   564 EMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRLK-- 626
            |.....:   ||.||    .|.:..::..:|.  |..:|....::.....|....|.|..:..
plant   271 EYGENGM---WNRLS----DLQTGKQLTMEEF--EKSVGYSSVVKDLMRRENANSTMDFRKFNSY 326

  Fly   627 -KKTARIKRFFGSTMRKTV-DKAKSIASEVSHARHKEDVAD------IVDAMNPEQNIKIKASSS 683
             .|:.|:.:..|:.:.|.: |.|.|::|.....:.|:....      :.:..|.:.|..:|...|
plant   327 VSKSLRVSKKRGAALLKNIKDVAHSMSSSKVSEKEKDSTGSGTSSPKVAEKNNEQANQWVKVRHS 391

  Fly   684 NKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDA------------ 736
            .|...:.:.|...|::.... ..:|.||||....|||:||:|..:.:|.:::.
plant   392 GKSHKDLSALHMCQEIQAHQ-GGIWTMKFSPDSHLLASAGEDCAIHVWEVQECEIMSMNEGSLTP 455

  Fly   737 -YPFFQDMRNK--------YNADQKSSPTPSQESLVSQ-----HSAEEAIAMATAAEKCTGPFMP 787
             :|......:|        .:.|:|.....|.....:|     |:.|...:::           .
plant   456 IHPSMSGSTDKSSEGDAAEVSQDKKKKGKTSMSKKGNQIPDYVHAPETVFSLS-----------D 509

  Fly   788 KPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRY 852
            ||.|::.||..|:||:|||::..:||||||||||||.|..:.||..|.|.|:||.:.|:|.|:.|
plant   510 KPICSFTGHLDDVLDLSWSRSQLLLSSSMDKTVRLWDIETQSCLKLFAHNDYVTCVQFNPLDEDY 574

  Fly   853 FLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLKYH 917
            |:|||||.|:|:|||.:::|..||::   .:::||..:..:||.|.|||.:|.|..|:.:..|..
plant   575 FISGSLDAKIRIWNISNRQVVEWNDL---KEMVTAVCYTPDGQAAFVGSINGHCRLYSAEDCKLE 636

  Fly   918 TQIHVRSTRGKNRIGRKISGIEPMP-GEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIK 981
            ....:.....|....:||:..:..| ...::||||.|||:|:.|  ...|..|::|:.|::||:.
plant   637 QTNQIDLQNKKKAQAKKITAFQFSPINPSEVLVTSADSRIRVLD--GTELVQKFRGFKNMNSQMT 699

  Fly   982 GSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAIFAPHP---- 1042
            .|::.|.|:|:..||:..:|:||  |:..:|            ||........|..:...|
plant   700 ASYTVDAKHIVCASEDSQVYVWK--HEEPRL------------GITGRKTVTMCTSYETFPCKDV 750

  Fly  1043 ------EAIIKPEPDEISNE 1056
                  ..::|.||....::
plant   751 SVAVPWNGVVKGEPPSTQHQ 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	7/42 (17%)
		WD40	704..1101	CDD:225201	118/389 (30%)
		WD40	704..1046	CDD:295369	115/378 (30%)
		WD40 repeat	707..765	CDD:293791	17/78 (22%)
		WD40 repeat	800..834	CDD:293791	20/33 (61%)
		WD40 repeat	841..878	CDD:293791	19/36 (53%)
		WD40 repeat	885..920	CDD:293791	12/34 (35%)
		WD40 repeat	935..975	CDD:293791	14/40 (35%)
		WD40 repeat	978..1003	CDD:293791	9/24 (38%)
		WD40 repeat	1034..1069	CDD:293791	5/32 (16%)
AT5G02430	NP_195863.1	WD40	347..779	CDD:225201	130/454 (29%)
		WD40	405..722	CDD:295369	108/333 (32%)
		WD40 repeat	414..459	CDD:293791	12/44 (27%)
		WD40 repeat	504..556	CDD:293791	26/62 (42%)
		WD40 repeat	563..599	CDD:293791	18/35 (51%)
		WD40 repeat	604..641	CDD:293791	12/36 (33%)
		WD40 repeat	654..690	CDD:293791	13/37 (35%)
		WD40 repeat	697..721	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I1203
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.930