DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and Wdr44

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001292604.1	Gene:	Wdr44 / 72404	MGIID:	1919654	Length:	915	Species:	Mus musculus

Alignment Length:	1175	Identity:	433/1175 - (36%)
Similarity:	576/1175 - (49%)	Gaps:	346/1175 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LETDSDSSEEFFDAEDTTPNRHSTLCRKLPPEVAQEFIFPEPAVRVNAAASSDSDATPIGAGTPA 68
            :.::|| :|||:||               |.:|                        .:|.|.|
Mouse     1 MASESD-TEEFYDA---------------PEDV------------------------HLGTGYP- 24

  Fly    69 TRSPTNSLGARLKPQDAGVFVEPKPVIGPLGRQRFHELRQCMQNDEDDNPGNTLTPDSQNSSTDG 133
            ..||                       |.:|...|.|.........:::|...|..|......:.
Mouse    25 VGSP-----------------------GKVGLLSFKEAENTANQAGNESPVQELRQDVSKKIIES 66

  Fly   134 IFTNRSTHPFKVIETDAMSIQS----MTSLGRVGRILAG---SIDPSAISIDRESLASLNAQQQK 191
            |.....    ||::.:..|:.|    ::.....|..:||   |..|..::|:.|      .||..
Mouse    67 IIEESQ----KVLQLEDDSLDSKGKGLSDEATAGPSVAGTEFSNIPGLLAIEHE------LQQDS 121

  Fly   192 QQAQQQQQAQ----------PTSSTSSNTPPSVGNT------SSGMSTPRVSPKHQQSGKEVAAT 240
            ::|:.|..|:          |:..|...:..:|..|      |||........:.:...||....
Mouse   122 EKAESQNVAEESELETQKCFPSDETCEKSEKTVDETDNLTEVSSGEQLDASGLEAETLNKEALEV 186

  Fly   241 TTG---IPSAASSAQSSGVGSM-----------VLQEPDVIASTKLAQSKTTDSITSSGP----- 286
            ..|   .|::..:..::...::           :..|||::||||..........|:..|
Mouse   187 KEGDVLDPASLDTLSTTDFAAVEEVAPAKPPRHLTPEPDIVASTKKPVPARPPPPTNFPPPRPPP 251

  Fly   287 ---VAPPRRKKKSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFES---- 344
               .|||.|||||.                                          :|||:
Mouse   252 PSRPAPPPRKKKSE------------------------------------------LEFEALKTP 274

  Fly   345 ----SLNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQS 405
                ...|.||. |.:|...:|.|||          ..||||.       .:||.| :|.|:.
Mouse   275 DLDVPKENITSD-SLLTTNMASENTV----------RDSLPSL-------DLASAT-SGDKIV-- 318

  Fly   406 LGSSSTSVHSKPSPSNSAKSNSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDE 470
                            :|:.|.....|.::                        :.:..||.
Mouse   319 ----------------TAQENGKAPDVQTV------------------------AGEVMGPQ--- 340

  Fly   471 IERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTS 535
                                                                        |.|::
Mouse   341 ------------------------------------------------------------RPRSN 345

  Fly   536 SGKQLTDFEILEQVPVKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDEESV 600
            ||::|||.|||..|.:|||||||.:||| :....:|.|.|||:|||::.|.  |.:..::.
Mouse   346 SGRELTDEEILASVMIKNLDTGEEIPLS-LAEEKLPTGINPLTLHIMRRTK--EYVSNDAT---- 403

  Fly   601 IGIPPSIEGQQPDEEELETE----DGSRLKKKTARIKRFFGSTMR-----------KTVDKAKSI 650
                     |..|||:|:::    ||.|||:||.::|:|.|.:::           :.::|.||:
Mouse   404 ---------QSDDEEKLQSQQTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKVKSV 459

  Fly   651 ASEVSHARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSC 715
            ..||.|....:..:...:.|...:.:|.||:...||||:|.:::.|||||||...|||.||||.|
Mouse   460 RDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKFSHC 524

  Fly   716 GRLLATAGQDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATAAEK 780
            |||||:||||.::|||.||:|:.:|.:||.|||.:.:.||:||||||.|..|       .|....
Mouse   525 GRLLASAGQDNIVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKS-------DTDMGV 582

  Fly   781 CTG----------PFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQ 835
            |:|          ||..:|||.|.|||:||||:|||||||:||||||||||||||||:|||||||
Mouse   583 CSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQ 647

  Fly   836 HIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVG 900
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||::||:|
Mouse   648 HIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIG 712

  Fly   901 SYDGRCIFYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLN 965
            :||||||||:|:.||||||||||||||:|::||||:||||:|||:||||||||||:||||||||:
Mouse   713 TYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLS 777

  Fly   966 LSCKYKGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHN 1030
            ||.|||||:|.|||||.|||||..|:::|||::.:|||.|.||.||.:||||||:||||||||||
Mouse   778 LSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHN 842

  Fly  1031 ATVTCAIFAPHPEAIIKPEPDEISNEKLAHNQPDPLVEQHKKGC-----GYVLVSADFNGAIKVF 1090
            |.||.|||||:|..::..:......|.:...:...:::....|.     ..||:||||.||||||
Mouse   843 AVVTSAIFAPNPSLMLSLDVQSEKLEGIDKYEDAEVLDSTSTGIVKTDNTEVLLSADFTGAIKVF 907

  Fly  1091 INKTK 1095
            |||.|
Mouse   908 INKRK 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1101	CDD:225201	273/407 (67%)
		WD40	704..1046	CDD:295369	255/351 (73%)
		WD40 repeat	707..765	CDD:293791	36/57 (63%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	33/39 (85%)
		WD40 repeat	978..1003	CDD:293791	14/24 (58%)
		WD40 repeat	1034..1069	CDD:293791	8/34 (24%)
Wdr44	NP_001292604.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		11/62 (18%)
		Binding activity	2..173		45/244 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..102		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..174		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..282		20/115 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..425		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..481		4/19 (21%)
		WD 1	511..550		24/38 (63%)
		WD40	512..859	CDD:392136	255/353 (72%)
		WD40 repeat	516..607	CDD:293791	47/97 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..593		13/40 (33%)
		WD 2	607..645		33/37 (89%)
		WD40 repeat	613..647	CDD:293791	30/33 (91%)
		WD 3	647..687		39/39 (100%)
		WD40 repeat	652..688	CDD:293791	35/35 (100%)
		WD 4	692..731		31/38 (82%)
		WD40 repeat	698..731	CDD:293791	25/32 (78%)
		WD 5	742..781		31/38 (82%)
		WD40 repeat	747..783	CDD:293791	29/35 (83%)
		WD 6	786..825		23/38 (61%)
		WD 7	840..880		13/39 (33%)
		WD 8	882..915		17/31 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850065
Domainoid	1	1.000	205	1.000	Domainoid score	I2928
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	670	1.000	Inparanoid score	I740
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		oto92271
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	LDO	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790