DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and wdr44

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001093508.1	Gene:	wdr44 / 569045	ZFINID:	ZDB-GENE-030131-9549	Length:	904	Species:	Danio rerio

Alignment Length:	1157	Identity:	437/1157 - (37%)
Similarity:	575/1157 - (49%)	Gaps:	319/1157 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LETDSDSSEEFFD-AEDT--TPNRHSTLCR-KLP----------PEVAQEFIFPEP----AVRVN 50
            :.:|:..:|||:| |||.  ||:.|::..: :||          .|||.....|||    ::::.
Zfish     1 MASDTSDTEEFYDAAEDVNFTPSPHASPAKFELPQPGGPTESVVQEVAAGLAQPEPRHDDSLQII 65

  Fly    51 AAASSDSDATPIGAGTPATRS--PTNSLGARLKPQDAGVFVEPKPVIGPLGRQRFHELRQCMQND 113
            .:...:|..:.:......|..  ..:|.|.:.:.:|..|...|.|.:          |...:..|
Zfish    66 DSIIEESQKSGVEEELLRTEDTCEASSEGEKPEAEDCSVEETPAPEV----------LVVVLPED 120

  Fly   114 EDDNPGNT----LTPDSQNSSTDGIFTNRSTHPFKVIETDAMSIQSMTSLGRVGRILAGSIDPSA 174
            .|..|.::    ..||              ..|.:|...|         :..:...:|||
Zfish   121 PDVTPRDSGCTEQVPD--------------VRPREVRPQD---------IHDIAPDVAGS----- 157

  Fly   175 ISIDRESLASLNAQQQKQQAQQQQQAQPTSSTSSNTPPSVGNTSSGMSTPRVSPKHQQSGKEVAA 239
                            .|..|.|....|...||     ::|..|..:|.|             .|
Zfish   158 ----------------AQVGQDQGIPPPPDITS-----ALGQPSLPVSLP-------------CA 188

  Fly   240 TTTGIPSAASSAQSSGVG-----SMVLQEPDVIASTKLAQSKTTDSITSSGPVAPPRRKKKSRNC 299
            .|..|....|::...|.|     .....|||::||||..........:.:.|..||
Zfish   189 ETADILEQVSTSDGDGPGPSKPPRQFTVEPDIVASTKKQPPSRPPPPSGAPPPRPP--------- 244

  Fly   300 SISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVMEFESSLNNATSSASNITLTCSSTN 364
                      ||:                      |..|
Zfish   245 ----------PPS----------------------RPSF-------------------------- 251

  Fly   365 TVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQSLGSSSTSVHSKPSPSNSAKSNSAP 429
                 |||..:..:..|:.:.:.:.|......:..|                          :|.
Zfish   252 -----SASKKSQEAIRPTGLEVSIEPAEELCGLVSP--------------------------NAT 285

  Fly   430 ARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLAGTGSNS 494
            .|..:.:....|:|..|..|..||..::
Zfish   286 VRCITKEVQHSLDLASATSGDKVVTAQE------------------------------------- 313

  Fly   495 LGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLDTGEN 559
                          ||::....:|.|....|     |.|::||::|||.|||..|.:|||||||.
Zfish   314 --------------NDEQASSPSGAETAGPQ-----RPRSNSGRELTDEEILASVMIKNLDTGEE 359

  Fly   560 MPLSEMRSPPVPEGWNPLSLHILKLTSHL---EVIQKESDEESVIGIPPSIEGQQPDEEELETED 621
            :||.:... .:|.|.|||:|||::.|...   :..|.:.|::|           ||   .|...|
Zfish   360 IPLIQAEE-KLPTGINPLTLHIMRRTKEYISNDAAQSDDDDKS-----------QP---ALTDTD 409

  Fly   622 GSRLKKKTARIKRFFGSTMR-----------KTVDKAKSIASEVSHARHKEDVADIVDAMNPEQN 675
            |.:||::|.::|:|.|.:::           :.|:|.||:..||.|....:..:...:.|...:.
Zfish   410 GGKLKQRTTQLKKFLGKSVKRAKHLAEEYGERAVNKVKSVRDEVFHNDQDDPSSSDDEGMPYTRP 474

  Fly   676 IKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCGRLLATAGQDKVLRIWVLKDAYPFF 740
            :|.||:.|.|||::|.:::.|||||||...|||.||||.|||||||||||.::||||||:||.:|
Zfish   475 VKFKAAHSFKGPFDFDQIKVVQDLSGEHMGAVWTMKFSHCGRLLATAGQDNIVRIWVLKNAYDYF 539

  Fly   741 QDMRNKYNADQKSSPTPSQESLVSQHSAEE-----AIAMATAAEKCTGPFMPKPFCTYNGHTSDL 800
            .:||.|||.:.:.||:||||||.|..|..|     |:..|...:: ..||...|||.|.|||:||
Zfish   540 NNMRIKYNTEGRVSPSPSQESLCSSKSDTEGGFGAAVEDADTEDR-NVPFRQVPFCKYKGHTADL 603

  Fly   801 LDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLW 865
            ||:|||||||:||||||||||||||||:|||||||||||||||||||||||||||||||||||||
Zfish   604 LDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLW 668

  Fly   866 NIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYNTDQLKYHTQIHVRSTRGKNR 930
            |||||||||||||||||:|||||||||||::||:|:||||||||:|::||||||||||||||:||
Zfish   669 NIPDKKVALWNEVDGQTRLITAANFCQNGKYAVIGTYDGRCIFYDTERLKYHTQIHVRSTRGRNR 733

  Fly   931 IGRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKGYLNVSSQIKGSFSHDGKYIIAGS 995
            :||||:||||:|||:||||||||||:||||||||:||.|||||:|.|||||.|||||..||::||
Zfish   734 VGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKGYVNSSSQIKASFSHDYSYIVSGS 798

  Fly   996 ENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAIFAPHPEAIIKPEPDEISNEKLAH 1060
            |::.:|||.|.||.||.:||||||:|||||||||||.||.|||||||:.|:   |.|..:||
Zfish   799 EDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAIFAPHPDLIV---PQEAGSEK--- 857

  Fly  1061 NQPD-----------------PLVEQHKKGCGYVLVSADFNGAIKVFINKTK 1095
              ||                 .|...|.:    ||:||||.||||||:|..|
Zfish   858 --PDSDCKSDSTDDSETIPSGALKTDHSE----VLLSADFTGAIKVFVNVKK 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1101	CDD:225201	283/414 (68%)
		WD40	704..1046	CDD:295369	260/346 (75%)
		WD40 repeat	707..765	CDD:293791	39/57 (68%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	33/39 (85%)
		WD40 repeat	978..1003	CDD:293791	15/24 (63%)
		WD40 repeat	1034..1069	CDD:293791	16/51 (31%)
wdr44	NP_001093508.1	WD40	489..902	CDD:225201	290/425 (68%)
		WD40	502..843	CDD:295369	256/341 (75%)
		WD40 repeat	506..546	CDD:293791	28/39 (72%)
		WD40 repeat	551..598	CDD:293791	19/47 (40%)
		WD40 repeat	603..637	CDD:293791	30/33 (91%)
		WD40 repeat	644..681	CDD:293791	36/36 (100%)
		WD40 repeat	688..723	CDD:293791	27/34 (79%)
		WD40 repeat	738..778	CDD:293791	33/39 (85%)
		WD40 repeat	782..806	CDD:293791	14/23 (61%)
		WD40 repeat	837..879	CDD:293791	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595912
Domainoid	1	1.000	205	1.000	Domainoid score	I2879
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	680	1.000	Inparanoid score	I686
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		otm25295
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	LDO	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790