DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and WDR44

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_061918.3	Gene:	WDR44 / 54521	HGNCID:	30512	Length:	913	Species:	Homo sapiens

Alignment Length:	1181	Identity:	438/1181 - (37%)
Similarity:	589/1181 - (49%)	Gaps:	360/1181 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LETDSDSSEEFFDA-EDT---------TPNR-----------------HSTLCRKLPPEVAQEFI 41
            :.::|| :|||:|| ||.         :|.:                 :.:..::|..:|:::.|
Human     1 MASESD-TEEFYDAPEDVHLGGGYPVGSPGKVGLSTFKETENTAYKVGNESPVQELKQDVSKKII 64

  Fly    42 --FPEPAVRV-----------NAAASSDSDATPIGAGTPATRSPTNSLGARLKPQDA------GV 87
              ..|.:.:|           ....|..:.|:||.|.|..:..|......::.|:::      ..
Human    65 ESIIEESQKVLQLEDDSLDSKGKELSDQATASPIVARTDLSNIPGLLAIDQVLPEESQKAESQNT 129

  Fly    88 FVEPKPVIGPLGRQRFHELRQCMQNDED-DNPGNTLTPDSQNSSTDGIFTNRSTHPFKVIETDAM 151
            |.|.:           .||::|..:||. :.|.:..|..:|.|||:.:....:       ||:.:
Human   130 FEETE-----------LELKKCFPSDETCEKPVDETTKLTQTSSTEQLNVLET-------ETEVL 176

  Fly   152 SIQSMTSLGRVGRILAGSIDPSAISIDRESLASLNAQQQKQQAQQQQQAQPTSSTSSNTPPSVGN 216
            :.:::...|. |.:|                                  :|.||.|.:|......
Human   177 NKEAVEVKGG-GDVL----------------------------------EPVSSDSLSTKDFAAV 206

  Fly   217 TSSGMSTPRVSPKHQQSGKEVAATTTGIPSAASSAQSSGVGSMVLQEPDVIASTKLAQSKTTDSI 281
            .....:.|   |:|                             :..|||::||||..........
Human   207 EEVAPAKP---PRH-----------------------------LTPEPDIVASTKKPVPARPPPP 239

  Fly   282 TSSGP--------VAPPRRKKKSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDF 338
            |:..|        .|||.||:||.
Human   240 TNFPPPRPPPPSRPAPPPRKRKSE----------------------------------------- 263

  Fly   339 VMEFES-SLNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKL 402
             :|||: ...:......|||                   |.||                     |
Human   264 -LEFETLKTPDIDVPKENIT-------------------SDSL---------------------L 287

  Fly   403 TQSLGSSSTSVHSKPSPSNSAKSNSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPS 467
            |.|:.|.||...|:||                      |:|..|..|
Human   288 TASMASESTVKDSQPS----------------------LDLASATSG------------------ 312

  Fly   468 QDEIERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRT 532
             |:|                                    |..:|..|:...:.|..::....|.
Human   313 -DKI------------------------------------VTAQENGKAPDGQTVAGEVMGPQRP 340

  Fly   533 RTSSGKQLTDFEILEQVPVKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQKESDE 597
            |::||::|||.|||..|.:|||||||.:||| :....:|.|.|||:|||::.|.  |.:..::
Human   341 RSNSGRELTDEEILASVMIKNLDTGEEIPLS-LAEEKLPTGINPLTLHIMRRTK--EYVSNDA-- 400

  Fly   598 ESVIGIPPSIEGQQPDEEELETE----DGSRLKKKTARIKRFFGSTMR-----------KTVDKA 647
                       .|..|||:|:::    ||.|||:||.::|:|.|.:::           :.::|.
Human   401 -----------AQSDDEEKLQSQPTDTDGGRLKQKTTQLKKFLGKSVKRAKHLAEEYGERAINKV 454

  Fly   648 KSIASEVSHARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKF 712
            ||:..||.|....:..:...:.|...:.:|.||:...||||:|.:::.|||||||...|||.|||
Human   455 KSVRDEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFDQIKVVQDLSGEHMGAVWTMKF 519

  Fly   713 SSCGRLLATAGQDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATA 777
            |.||||||:||||.|:|||.||:|:.:|.:||.|||.:.:.||:||||||.|..|       .|.
Human   520 SHCGRLLASAGQDNVVRIWALKNAFDYFNNMRMKYNTEGRVSPSPSQESLSSSKS-------DTD 577

  Fly   778 AEKCTG----------PFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLC 832
            ...|:|          ||..:|||.|.|||:||||:|||||||:||||||||||||||||:||||
Human   578 TGVCSGTDEDPDDKNAPFRQRPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLC 642

  Fly   833 CFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFA 897
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||::|
Human   643 CFQHIDFVTAIAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGKYA 707

  Fly   898 VVGSYDGRCIFYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDSRVRLYDLR 962
            |:|:||||||||:|:.||||||||||||||:|::||||:||||:|||:||||||||||:||||||
Human   708 VIGTYDGRCIFYDTEHLKYHTQIHVRSTRGRNKVGRKITGIEPLPGENKILVTSNDSRIRLYDLR 772

  Fly   963 DLNLSCKYKGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIK 1027
            ||:||.|||||:|.|||||.|||||..|:::|||::.:|||.|.||.||.:||||||:|||||||
Human   773 DLSLSMKYKGYVNSSSQIKASFSHDFTYLVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIK 837

  Fly  1028 AHNATVTCAIFAPHPEAII-------KPEPDEISNE-KLAHNQPDPLVEQHKKGCGYVLVSADFN 1084
            ||||.||.|||||:|..::       |.|.:|.|.: ::....|..::   |.....||:||||.
Human   838 AHNAVVTSAIFAPNPSLMLSLDVQSEKSEGNEKSEDAEVLDATPSGIM---KTDNTEVLLSADFT 899

  Fly  1085 GAIKVFINKTK 1095
            ||||||:||.|
Human   900 GAIKVFVNKRK 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1101	CDD:225201	277/410 (68%)
		WD40	704..1046	CDD:295369	256/351 (73%)
		WD40 repeat	707..765	CDD:293791	37/57 (65%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	33/39 (85%)
		WD40 repeat	978..1003	CDD:293791	14/24 (58%)
		WD40 repeat	1034..1069	CDD:293791	12/42 (29%)
WDR44	NP_061918.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		9/23 (39%)
		Binding activity	2..170		36/179 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..348		51/333 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..480		4/20 (20%)
		WD 1	509..548		25/38 (66%)
		WD40	510..857	CDD:238121	256/353 (73%)
		WD40 repeat	514..562	CDD:293791	29/47 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..593		13/42 (31%)
		WD 2	605..643		33/37 (89%)
		WD40 repeat	610..644	CDD:293791	30/33 (91%)
		WD 3	645..685		39/39 (100%)
		WD40 repeat	651..688	CDD:293791	36/36 (100%)
		WD 4	690..729		31/38 (82%)
		WD40 repeat	695..730	CDD:293791	27/34 (79%)
		WD 5	740..779		31/38 (82%)
		WD40 repeat	745..785	CDD:293791	33/39 (85%)
		WD 6	784..823		23/38 (61%)
		WD40 repeat	789..813	CDD:293791	13/23 (57%)
		WD 7	876..913		17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159693
Domainoid	1	1.000	205	1.000	Domainoid score	I2937
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I732
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		oto88703
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	LDO	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790