DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and SPAC3H5.08c

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_594184.2	Gene:	SPAC3H5.08c / 2543641	PomBaseID:	SPAC3H5.08c	Length:	933	Species:	Schizosaccharomyces pombe

Alignment Length:	810	Identity:	250/810 - (30%)
Similarity:	359/810 - (44%)	Gaps:	231/810 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 VTIAGPK-----LTQSLGSSSTSVHSKPSPSNSAK------SNSAPARVSSIDPNQGLNLFKAIQ 448
            :.|..||     |.....::....|.||.....|.      |:|..:|..|.|.|
pombe     8 IQIQSPKNSLDHLNNGRQATHNFEHGKPGDREEANGHADAHSSSGRSRYLSSDTN---------- 62

  Fly   449 GGYVVKPRDEASNKAQGPSQDEIERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKER 513
                 ..||.:|:         ::.:.|.:|:.....|.....:.|..||..:
pombe    63 -----LLRDGSSS---------LDPLSKHIMKRTRSEKTLSFLNPSRASSNTH------------ 101

  Fly   514 RKSAGDEDVLKQMNIYVRTRTSSGKQLTDFEILEQVPVKNLDTGENMPLS-----EMRSPPVPEG 573
               ...|...:..|:   |||.||::......|       .||||:..||     .:|.|  .:.
pombe   102 ---LSREGTNRSSNV---TRTVSGRKSNHGSSL-------TDTGESDQLSLKSFGAIRQP--SQH 151

  Fly   574 WNPLSLHILKLTSHL----EVIQKESDEESVIGIPPSIEGQQPDEEELETEDGSRL--------- 625
            .:.|...:|..|||:    |.:..||.||...|| |.:||...|.... ..||..:
pombe   152 RSSLFSRMLGSTSHIFGIREDMDNESSEEERDGI-PRVEGNAADPFSW-IPDGKNVWDSPPKYIR 214

  Fly   626 ----KKKTARIKRFF-------GSTMRKTVDK-----------AKSIASEVSHARHKEDVADIVD 668
                .||...:...|       ..|:..|.|:           ....:||.|.:||..|...|.:
pombe   215 VLSHNKKEKSLDHLFLAQELYCKPTLAATHDRYYEPRATDFPNLAHESSEPSSSRHTADAQSITN 279

  Fly   669 AMNPEQNIKIKASSS--NKGPYEFTKLQHV----QDLSGEDTSAVWCMKFSSCGRLLATAGQDKV 727
            |     ::.:..|||  |:.|...:....|    ...|....:|:|.||||..||.||..|||::
pombe   280 A-----SVHLHNSSSPLNRTPSVISDTLAVAITSNSSSNSSNNAIWAMKFSRDGRYLAVGGQDRI 339

  Fly   728 LRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHSAEEAIAMATAAEKCTG-PFMPK--- 788
            ||||.:.|                            |:|      |.:.|:|.|:. |..||
pombe   340 LRIWAVLD----------------------------SEH------ARSVASETCSSDPNNPKLNL 370

  Fly   789 --------PFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTAIAF 845
                    |...|.|||:|:||:|||:|.|:||||||||.||||..||:|||||:|.||||:|||
pombe   371 KAPVFSEAPIREYAGHTADILDLSWSRNNFLLSSSMDKTARLWHPVRKDCLCCFEHSDFVTSIAF 435

  Fly   846 HPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCIFYN 910
            ||:|||:|||||||.|||||:|.:|.|:.|||:   .:||||..|..:|..|:.|::.|.|:||:
pombe   436 HPKDDRFFLSGSLDCKLRLWSIKEKAVSFWNEL---PELITAVAFSPDGGLAIAGTFVGLCLFYD 497

  Fly   911 TDQLKYHTQIHVRSTRGKNRIGRKISGIEP-------MPGEDKILVTSNDSRVRLYDLRDLNLSC 968
            |..|::.||:.:||:||||..|.|::||:.       :.|:.::|||:||||:|:|:|||.:|..
pombe   498 TRGLRFRTQMSIRSSRGKNAKGSKVTGIQTRTQMIDNIAGDTEMLVTTNDSRIRIYNLRDKSLEL 562

  Fly   969 KYKGYLNVSSQIKGSFSHDGKYIIAGSENQCIYIW-----------KTNHDYSKLSSVRRDRSDF 1022
            |:||:.|..||.:..|..||.|:|.|||:..::||           |..|::.| :|||
pombe   563 KFKGHANAQSQNRAYFDDDGNYVICGSEDHQVFIWDLPPQHMHKTKKKKHEHFK-ASVR------ 620

  Fly  1023 WEGIKAHNATVTCAIFAP--------------HPEAIIKPEPDEISN------------EKLAHN 1061
                     .:|.|:|||              :..||.......|||            :.|:|:
pombe   621 ---------PITAAVFAPTKTKQLLTLSGDPVYLAAISARRSSVISNASIETGPSLRNLKSLSHS 676

  Fly  1062 Q-PDPLVEQHKKGCGYVLVSADFNGAIKVF 1090
            . |..:::      |:::|..|.:|.|:||
pombe   677 YLPIEIMK------GHIIVCGDLDGRIRVF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	8/42 (19%)
		WD40	704..1101	CDD:225201	172/444 (39%)
		WD40	704..1046	CDD:295369	158/385 (41%)
		WD40 repeat	707..765	CDD:293791	17/57 (30%)
		WD40 repeat	800..834	CDD:293791	24/33 (73%)
		WD40 repeat	841..878	CDD:293791	26/36 (72%)
		WD40 repeat	885..920	CDD:293791	14/34 (41%)
		WD40 repeat	935..975	CDD:293791	19/46 (41%)
		WD40 repeat	978..1003	CDD:293791	10/24 (42%)
		WD40 repeat	1034..1069	CDD:293791	13/61 (21%)
SPAC3H5.08c	NP_594184.2	WD40	319..>600	CDD:225201	145/317 (46%)
		WD40	319..598	CDD:295369	144/315 (46%)
		WD40 repeat	319..349	CDD:293791	17/57 (30%)
		WD40 repeat	390..425	CDD:293791	25/34 (74%)
		WD40 repeat	431..467	CDD:293791	25/35 (71%)
		WD40 repeat	472..507	CDD:293791	14/34 (41%)
		WD40 repeat	522..569	CDD:293791	19/46 (41%)
		WD40 repeat	655..707	CDD:293791	13/52 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2026
eggNOG	1	0.900	-	-		E1_KOG0283
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		oto100624
orthoMCL	1	0.900	-	-		OOG6_102303
Panther	1	1.100	-	-	LDO	PTHR14221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
TreeFam	1	0.960	-	-
	11	10.800