DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34133 and wdr44

DIOPT Version :9

Sequence 1:	NP_001036772.2	Gene:	CG34133 / 318566	FlyBaseID:	FBgn0083969	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_002939709.1	Gene:	wdr44 / 100379800	XenbaseID:	XB-GENE-1007867	Length:	912	Species:	Xenopus tropicalis

Alignment Length:	1168	Identity:	448/1168 - (38%)
Similarity:	581/1168 - (49%)	Gaps:	335/1168 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LETDSDSSEEFFDAEDTTPNRHSTLCR-KLPPEVAQEFIFPEPAVRVNAAASSDSDATPIGAGTP 67
            :.:||| :||||||    |...:..|. .:.|..::.||..|....     |.:::...|.....
Frog     1 MASDSD-TEEFFDA----PEDVNLSCSPAVSPTKSETFILKEEVTH-----SRNAETRNIDLKQD 55

  Fly    68 ATRSPTNSLGARLK----PQDAGVFVEPKPVIGPLGRQRFHELRQCMQNDEDDNPGNTLTPDSQN 128
            .::...:|:....:    .::|...||.||.|       .||               |||.::..
Frog    56 DSKEIIDSIIEESQKYSDTENAHPVVEEKPEI-------LHE---------------TLTAETSK 98

  Fly   129 SS------------TDGIFTNRSTHPFKV-----IETDAMSIQSMTSLGRVGRILAG-SIDPSAI 175
            :|            |:..|.:....|.:.     :|.|....|.           || |.|||.:
Frog    99 TSQDLLSNIPELVVTESTFHDGVDDPVQQQIGEHVEPDNSRTQK-----------AGPSADPSYV 152

  Fly   176 SIDRESLASLN-----------AQQQKQQAQQQQQAQPTSSTSSNTPPSVGNTSSGMSTPRVSPK 229
            |...|::..|.           .::.:....|::...|:.....:..|::..:......|...|.
Frog   153 SSAIENIVDLTQDLKIIEDLKIEEEPEISLIQEENKDPSKHIVEDVLPNIPTSDILEQLPPAKPP 217

  Fly   230 HQQSGKEVAATTTGIPSAASSAQSSGVGSMVLQEPDVIASTKLAQSKTTDSITSSGPV------- 287
            .|                            :..|||::||||           ..||.
Frog   218 RQ----------------------------ICVEPDIVASTK-----------KPGPTRPPLPIN 243

  Fly   288 ------------APPRRKKKSRNCSISSSDQYSLPPADNEDTDSDTRSVKSVQGLQQKLRDDFVM 340
                        |||.|||||                   |||.|..|     |.:.: :|.|
Frog   244 VPPPRPPPPARPAPPPRKKKS-------------------DTDFDRSS-----GFEYQ-KDGF-- 281

  Fly   341 EFESSLNNATSSASNITLTCSSTNTVVSASASTSAASSSLPSTIAIHMRPMVASVTIAGPKLTQS 405
                 |.....|                            |:|                  ||::
Frog   282 -----LGGGLLS----------------------------PNT------------------LTEN 295

  Fly   406 LGSSSTSVHSKPSPSNSAKSNSAPARVSSIDPNQGLNLFKAIQGGYVVKPRDEASNKAQGPSQDE 470
            :...     |:||                      |:|..|..|..||..::   |......|..
Frog   296 MNRD-----SQPS----------------------LDLASATSGEKVVTAQE---NGKAADGQLS 330

  Fly   471 IERIEKMLMESANRPKLAGTGSNSLGSSTRYPGFYRGVNDKERRKSAGDEDVLKQMNIYVRTRTS 535
            .:.||                  |||..                                |.|::
Frog   331 CQAIE------------------SLGPQ--------------------------------RPRSN 345

  Fly   536 SGKQLTDFEILEQVPVKNLDTGENMPLSEMRSPPVPEGWNPLSLHILKLTSHLEVIQK---ESDE 597
            ||::|||.|||..|.:|||||||.:||| :....:|.|.|||:|||::.|.  |.:..   :||:
Frog   346 SGRELTDEEILASVMIKNLDTGEEIPLS-LAEEKLPTGINPLTLHIMRRTK--EYVSNDAAQSDD 407

  Fly   598 ESVIGIPPSIEGQQPDEEELETEDGSRLKKKTARIKRFFGSTMR-----------KTVDKAKSIA 651
            |           .:|...:.|| ||.:||:||.::|:|.|.:::           :.|:|.||:.
Frog   408 E-----------DKPQPHQSET-DGGKLKQKTTQLKKFLGKSVKRAKHLAEEYGERAVNKVKSVR 460

  Fly   652 SEVSHARHKEDVADIVDAMNPEQNIKIKASSSNKGPYEFTKLQHVQDLSGEDTSAVWCMKFSSCG 716
            .||.|....:..:...:.|...:.:|.||:...||||:|.:::.|||||||...|||.||||.||
Frog   461 DEVFHTDQDDPSSSDDEGMPYTRPVKFKAAHGFKGPYDFEQIKVVQDLSGEHVGAVWTMKFSHCG 525

  Fly   717 RLLATAGQDKVLRIWVLKDAYPFFQDMRNKYNADQKSSPTPSQESLVSQHS-AEEAIAMAT---A 777
            ||||:||||.|:||||||:|:.:|.:||.|||.:.:.||:||||||.|..| .:..:..||   .
Frog   526 RLLASAGQDNVVRIWVLKNAFDYFNNMRIKYNTEGRVSPSPSQESLNSSKSDTDGGVYSATDDMD 590

  Fly   778 AEKCTGPFMPKPFCTYNGHTSDLLDVSWSKNYFILSSSMDKTVRLWHISRKECLCCFQHIDFVTA 842
            .:....||...|||.|.|||:||||:|||||||:||||||||||||||||:||||||||||||||
Frog   591 PDDKNAPFRQVPFCKYKGHTADLLDLSWSKNYFLLSSSMDKTVRLWHISRRECLCCFQHIDFVTA 655

  Fly   843 IAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEVDGQTKLITAANFCQNGQFAVVGSYDGRCI 907
            |||||||||||||||||||||||||||||||||||:||||||||||||||||:.||:|:||||||
Frog   656 IAFHPRDDRYFLSGSLDGKLRLWNIPDKKVALWNEIDGQTKLITAANFCQNGKHAVIGTYDGRCI 720

  Fly   908 FYNTDQLKYHTQIHVRSTRGKNRIGRKISGIEPMPGEDKILVTSNDSRVRLYDLRDLNLSCKYKG 972
            ||:|:.||||||||||||||:||:||||:||||:|||:||||||||||:||||||||:||.||||
Frog   721 FYDTEHLKYHTQIHVRSTRGRNRVGRKITGIEPLPGENKILVTSNDSRIRLYDLRDLSLSMKYKG 785

  Fly   973 YLNVSSQIKGSFSHDGKYIIAGSENQCIYIWKTNHDYSKLSSVRRDRSDFWEGIKAHNATVTCAI 1037
            .:|.|||||.|||||..||::|||::.:|||.|.||.||.:||||||:|||||||||||.||.||
Frog   786 CVNSSSQIKASFSHDFTYIVSGSEDKYVYIWSTYHDLSKFTSVRRDRNDFWEGIKAHNAVVTSAI 850

  Fly  1038 FAPHPEAIIKPEPDEISNEKLAHNQPDPLVEQHKKGC-----GYVLVSADFNGAIKVFINKTK 1095
            |||:|..::..   |.|:||...:|.:| ||....|.     ..||:||||.|||||||||.|
Frog   851 FAPNPGLMVSA---ETSSEKQEGDQAEP-VENIPSGALKSDHTEVLLSADFTGAIKVFINKKK 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34133	NP_001036772.2	WD40 repeat	663..700	CDD:293791	12/36 (33%)
		WD40	704..1101	CDD:225201	281/401 (70%)
		WD40	704..1046	CDD:295369	256/345 (74%)
		WD40 repeat	707..765	CDD:293791	38/57 (67%)
		WD40 repeat	800..834	CDD:293791	30/33 (91%)
		WD40 repeat	841..878	CDD:293791	36/36 (100%)
		WD40 repeat	885..920	CDD:293791	27/34 (79%)
		WD40 repeat	935..975	CDD:293791	32/39 (82%)
		WD40 repeat	978..1003	CDD:293791	15/24 (63%)
		WD40 repeat	1034..1069	CDD:293791	14/34 (41%)
wdr44	XP_002939709.1	Aim21	<22..>236	CDD:371558	48/290 (17%)
		WD40	512..863	CDD:392136	256/353 (73%)
		WD40 repeat	516..556	CDD:293791	27/39 (69%)
		WD40 repeat	613..647	CDD:293791	30/33 (91%)
		WD40 repeat	654..691	CDD:293791	36/36 (100%)
		WD40 repeat	698..733	CDD:293791	27/34 (79%)
		WD40 repeat	748..788	CDD:293791	32/39 (82%)
		WD40 repeat	792..816	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I2990
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I730
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332590at2759
OrthoFinder	1	1.000	-	-		FOG0001775
OrthoInspector	1	1.000	-	-		oto102570
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1821
SonicParanoid	1	1.000	-	-		X637
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090