Protein Alignment CG31019 and AGBL5

DIOPT Version :10

• Sequence 1: NP_733391.1
• Gene: CG31019 / 318558
• FlyBaseID: FBgn0051019
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_068603.4
• Gene: AGBL5 / 60509
• HGNCID: 26147
• Length: 886
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 183/766 - (23%)
• Similarity: 294/766 - (38%)
• Gaps: 223/766 - (29%)

  Fly    51 GHLCFDAAFETGNLGKAELV------GE------------------FEYDLFLRPDTCNPRF--- 88
            |.|.|.:.|::|||...|.|      ||                  :|::::.|||.....|
Human     6 GGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENG 70

  Fly    89 -RFWFNFTVDNVKQDQRVLFHIVNISKSRNLFSSGLTPLVKS-SSRPKWQRLSKRQVFFYRSAMH 151
             |.||.|:|......:.:..:|:|::|...|:|.|:.|.|:: .:||:|:|:..|..|    .|.
Human    71 NRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTF----EMT 131

  Fly   152 QGHYVLSFA--FIFDKEEDVYQFALAWPYSYSRLQSYLNVIDARQGSDK----------RFTRCV 204
            :..:||||.  |:..:....: ||..:|:|||..|..||.:|.|...:.          .:.|.:
Human   132 ETQFVLSFVHRFVEGRGATTF-FAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHREL 195

  Fly   205 LVKSLQNRNVDLLTID--HVTAKQRSTNRLDRSF-------------IRVIVVLCRTHSSEAPAS 254
            |..||....||||||.  |...:.|.. ||::.|             .|:..:..|.|..|.|:|
Human   196 LCYSLDGLRVDLLTITSCHGLREDREP-RLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSS 259

  Fly   255 HVCQGLIEFLV-GNHPIAAVLRDNFVFKIVPMVNPDGVFLGNNRCNLMGQDMNRNWHIGSEFTQP 318
            .|..|.::|:: .:.|.|..||..||||::||:|||||..|:.|.:..|.::||.:........|
Human   260 FVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHP 324

  Fly   319 ELHAVKGML------KELDN------------------SDVSRG--------------------- 338
            .::..|.:|      ..|::                  ||:.:.
Human   325 AIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAW 389

  Fly   339 -----IETDLIGIIFVCSYNISFQTYQID----------FVIDLHANSSMHGCFIYGNTYEDVYR 388
                 .|..|..:..:...:...:....|          :.:|||.::|..|||:|||::.|...
Human   390 KQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDEST 454

  Fly   389 YERHLVFPRLFASNAQDY------VADHTMFNADER----KAGSMRRFSCERLSDTVNAYTLEVS 443
            ...::::|:|.:.|:..:      .::..|:..|.|    |.|| .|.:..:.|..:::||||.:
Human   455 QVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGS-GRVAIYKASGIIHSYTLECN 518

  Fly   444 MAGHYLKDGKTI----------------------SLYNEDGYYRVGRNLARTLLQYYRFINILPM 486
                 ...|:::                      |.|..:.:.:|||.:|...|.... .|..|.
Human   519 -----YNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAE-CNPWPR 577

  Fly   487 PIVTE---VRSKRRGRNRHAHHSRSRSKT---RYEVKPRPKTPRCHAPIAYTNLSICYDSGGGGG 545
            .:::|   :.:.|....:|..:||..|.|   ....|...:||    |.::..|.:
Human   578 IVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTP----PKSHNGLPV--------- 629

  Fly   546 SSDEGGFSPARPLAPGSSCFSGYRNYRRAATASCSAHPGHDQYS-----PFALGALKTGSDHGGG 605
            |..|...|.||..:.|:|           |..|.|:.....|..     ||          ||..
Human   630 SCSENTLSRARSFSTGTS-----------AGGSSSSQQNSPQMKNSPSFPF----------HGSR 673

  Fly   606 VGGSKGKRSAA--VTIEVPLPVNVP--------PKPYLSIIDLNQLTRGSL 646
            ..|..|..|:.  ||..|..||..|        .:|      ||....|||
Human   674 PAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQP------LNHRPAGSL 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31019	NP_733391.1	Pepdidase_M14_N	55..>115	CDD:407865	21/87 (24%)
		M14_AGBL4_like	198..478	CDD:349479	87/397 (22%)
AGBL5	NP_068603.4	Pepdidase_M14_N	10..155	CDD:407865	40/149 (27%)
		M14_AGBL5_like	183..574	CDD:349455	87/398 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..364		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	605..734		36/154 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..848