DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31007 and CHCHD2

DIOPT Version :9

Sequence 1:	NP_733412.2	Gene:	CG31007 / 318553	FlyBaseID:	FBgn0051007	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_001307256.1	Gene:	CHCHD2 / 51142	HGNCID:	21645	Length:	168	Species:	Homo sapiens

Alignment Length:	177	Identity:	66/177 - (37%)
Similarity:	90/177 - (50%)	Gaps:	38/177 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRQRSEGPRS-TGSMRRQSSRSSHVFATKPSRGSSKDLPAVQQPKKESLPAAAPAASAATSTET 64
            |||    |.|| |..|...:||:..:      |.:.:..| |.||     |||||.::..:|  .
Human     1 MPR----GSRSRTSRMAPPASRAPQM------RAAPRPAP-VAQP-----PAAAPPSAVGSS--A 47

  Fly    65 KGPSTADRFKDMATTAAGVAAGSAVGHAVGAGLTGMFQGRGQAAPAK-----EQPQQEGSLAASA 124
            ..|........|||||||||.||||||.:|..:||.|.|...|.||:     ::||  |:..|..
Human    48 AAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQ--GTQPAQQ 110

  Fly   125 SQSVPKPQLVEDGPCAFELRQFLKCTEDNSSDLSVCKEFNEAMQQCR 171
            .|           ||.:|::|||:|.: |..|:.:|:.|||.::|||
Human   111 QQ-----------PCLYEIKQFLECAQ-NQGDIKLCEGFNEVLKQCR 145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31007	NP_733412.2	CHCH	139..173	CDD:284221	15/33 (45%)
CHCHD2	NP_001307256.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		21/66 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..111		12/35 (34%)
		CHCH	114..147	CDD:369061	15/33 (45%)
		Cx9C motif 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01150	114..124		5/9 (56%)
		Cx9C motif 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01150	134..144		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12296
eggNOG	1	0.900	-	-		E1_KOG4090
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54220
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13523
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2188
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.910