DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gskt and RIM11

DIOPT Version :9

Sequence 1:	NP_733426.1	Gene:	gskt / 318552	FlyBaseID:	FBgn0046332	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_013859.1	Gene:	RIM11 / 855170	SGDID:	S000004747	Length:	370	Species:	Saccharomyces cerevisiae

Alignment Length:	330	Identity:	167/330 - (50%)
Similarity:	235/330 - (71%)	Gaps:	9/330 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASQSKNS-GLTNKVTTVVATNAFGADVMS-----EISYTDAKVVGNGSFGVVFQAKMVPSNEMV 59
            |..||.|| .|:|.:.:.....|.....:.     :||:...:|||:|||||||...:..:||.|
Yeast     1 MNIQSNNSPNLSNNIVSKQVYYAHPPPTIDPNDPVQISFPTTEVVGHGSFGVVFATVIQETNEKV 65

  Fly    60 AIKKVLQDRRFKNRELQIMRKLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYA 124
            ||||||||:|||||||:||:.|.|.|||.||:||:.. :.:||:||||::|::|::||:..|.:.
Yeast    66 AIKKVLQDKRFKNRELEIMKMLSHINIIDLKYFFYER-DSQDEIYLNLILEYMPQSLYQRLRHFV 129

  Fly   125 RAKQTLPVNFVRLYMYQLLRSMGYLHSL-GFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGE 188
            ..:..:....::.||:||.:|:.|||.. ..|||||||||:|:|.||..||||||||||||...|
Yeast   130 HQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTE 194

  Fly   189 PNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTP 253
            |||||||||||||||||||:|:||.:||:||:||||:||||||.:|||:||:||:|||:|::|||
Yeast   195 PNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTP 259

  Fly   254 TSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFFD 318
            :.:::..|||:|.:.|.|::||.|.|:||: :...:.::.::.:|.|.|..|.:.|.....|:||
Yeast   260 SKQEICSMNPNYMEHKFPQIKPIPLSRVFK-KEDDQTVEFLADVLKYDPLERFNALQCLCSPYFD 323

  Fly   319 ELRQD 323
            ||:.|
Yeast   324 ELKLD 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gskt	NP_733426.1	STKc_GSK3	30..320	CDD:271039	156/290 (54%)
gskt	NP_733426.1	S_TKc	33..317	CDD:214567	152/284 (54%)
RIM11	NP_013859.1	STKc_GSK3	34..325	CDD:271039	156/292 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343774
Domainoid	1	1.000	344	1.000	Domainoid score	I149
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I387
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		mtm9205
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X378
TreeFam	1	0.960	-	-
	12	11.750