DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gskt and Gsk3a

DIOPT Version :9

Sequence 1:	NP_733426.1	Gene:	gskt / 318552	FlyBaseID:	FBgn0046332	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_038944440.1	Gene:	Gsk3a / 50686	RGDID:	620351	Length:	490	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	242/407 - (59%)
Similarity:	307/407 - (75%)	Gaps:	24/407 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KNSGLTNKVTTVVATNAFGADVMSEISYTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRF 70
            ::||   ||||||||...|.:...|::|||.||:||||||||:||::..:.|:|||||||||:||
  Rat    95 RDSG---KVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRF 156

  Fly    71 KNRELQIMRKLRHDNIITLKWFFFSSGE-------KRDEVYLNLVMEFLPETLYKVERQYARAKQ 128
            |||||||||||.|.||:.|::||:||||       |:||:|||||:|::|||:|:|.|.:.:||.
  Rat   157 KNRELQIMRKLDHCNIVRLRYFFYSSGEKVRHWESKKDELYLNLVLEYVPETVYRVARHFTKAKL 221

  Fly   129 TLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSY 193
            .:|:.:|::|||||.||:.|:||.|.|||||||||:|:|.:|.|||||||||||||:.|||||||
  Rat   222 IIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY 286

  Fly   194 ICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQL 258
            ||||||||||||||:||||:.||:||||||::||||||.||||||||||:|||:||:||||.||:
  Rat   287 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQI 351

  Fly   259 HDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQD 323
            .:|||:|.:||.|::|.|||:|||:.|||.|||.|.|.:|.|:|::|:|||..|||.|||||| .
  Rat   352 REMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR-S 415

  Fly   324 PHQQLPNGRSLPPLFNFTDYEKTIEPDTMPLLLP----RAQGSSTTKEPSAAHRNRNTAGEESPR 384
            ...||||.|.|||||||:..|.:|:|....:|:|    ...|.:|....|.|.....|.
  Rat   416 LGTQLPNNRPLPPLFNFSPGELSIQPSLNAILIPPHLRSPSGPATLTSSSQALTETQTG------ 474

  Fly   385 KTEDSQKP-ATAALSKS 400
              :|.|.| ||..|:.|
  Rat   475 --QDWQAPDATPTLTNS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gskt	NP_733426.1	STKc_GSK3	30..320	CDD:271039	199/296 (67%)
gskt	NP_733426.1	S_TKc	33..317	CDD:214567	195/290 (67%)
Gsk3a	XP_038944440.1	STKc_GSK3	114..413	CDD:271039	199/298 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D990896at2759
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X378
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850