DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gskt and gsk3

DIOPT Version :9

Sequence 1:	NP_733426.1	Gene:	gskt / 318552	FlyBaseID:	FBgn0046332	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_593134.1	Gene:	gsk3 / 2542652	PomBaseID:	SPAC1687.15	Length:	387	Species:	Schizosaccharomyces pombe

Alignment Length:	360	Identity:	199/360 - (55%)
Similarity:	269/360 - (74%)	Gaps:	13/360 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 MSEISYTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKNRELQIMRKLRHDNIITLKWF 92
            :.::|||.:||||:||||||.|..::.|:...|||:||||:|||||||||||.::|.||:.|..:
pombe    27 VKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAY 91

  Fly    93 FFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHR 157
            ::::|:..||||||||:||:|||:|:..|.|.|.|.::|:..|:||:||||||:.|:|:.|.|||
pombe    92 YYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHR 156

  Fly   158 DIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGC 222
            ||||||:|||.|.|:||||||||||.|::|||||||||||||||||||||:||||..||:||.||
pombe   157 DIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGC 221

  Fly   223 VMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTP 287
            ||:||:||..:|||:||:||:|||:|::|||:.||:..|||:|.:.:.|:::|.|.|:||....|
pombe   222 VMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVP 286

  Fly   288 AEAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDPHQQLPNGRS-------LPPLFNFTDYEK 345
            .:|:||:||||.|:|..|::......|||||||| ||:.:|.|.|:       ||.||||:.:|.
pombe   287 LDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELR-DPNTKLHNSRNPDASPRHLPELFNFSPFEL 350

  Fly   346 TIEPDTMPLLLP-RAQGSSTTK----EPSAAHRNR 375
            :|.||....|:| .|:.:...|    .|...||.|
pombe   351 SIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRAR 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gskt	NP_733426.1	STKc_GSK3	30..320	CDD:271039	173/289 (60%)
gskt	NP_733426.1	S_TKc	33..317	CDD:214567	169/283 (60%)
gsk3	NP_593134.1	STKc_GSK3	28..319	CDD:271039	173/290 (60%)
gsk3	NP_593134.1	S_TKc	32..316	CDD:214567	169/283 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I319
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		mtm9293
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X378
TreeFam	1	0.960	-	-
	11	10.820