DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gskt and gsk-3

DIOPT Version :9

Sequence 1:	NP_733426.1	Gene:	gskt / 318552	FlyBaseID:	FBgn0046332	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001379044.1	Gene:	gsk-3 / 173149	WormBaseID:	WBGene00001746	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	376	Identity:	234/376 - (62%)
Similarity:	291/376 - (77%)	Gaps:	24/376 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASQSKNSGLTNKVTTVVATNAF-GADVMSEISYTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKV 64
            :.|.|..||  .:||.|||:.|. |.|...||||.|.||:|||||||||.||:..:|||||||||
Worm     5 LLSCSLKSG--KQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKV 67

  Fly    65 LQDRRFKNRELQIMRKLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQT 129
            |||:|||||||||||||.|.||:.||:||:|||||:||:||||::|::|||:|:|.|.|::.:|.
Worm    68 LQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQ 132

  Fly   130 LPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYI 194
            :|:.:|:|||||||||:.|:||:|.|||||||||:|:|.|:||||||||||||.|:..|||||||
Worm   133 IPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYI 197

  Fly   195 CSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLH 259
            |||||||||||||:|:||..||:||||.||:||||||.||||||||||:|||:||:||||.||:.
Worm   198 CSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQ 262

  Fly   260 DMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDP 324
            .|||:||:||.|::|.|||:||||:.||||||||:||::.|:|.:|.:|...|.|.|||||| :|
Worm   263 SMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELR-NP 326

  Fly   325 HQQLPNGRSLPPLFNFTDYEKTIEPDTMPLLLPRAQGSSTTKE-----PSA 370
            ..:||:||.||          |:|.|.     |...|..:|..     |||
Worm   327 DARLPSGRPLP----------TLEMDG-----PMGTGEVSTTSGDVAGPSA 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gskt	NP_733426.1	STKc_GSK3	30..320	CDD:271039	203/289 (70%)
gskt	NP_733426.1	S_TKc	33..317	CDD:214567	197/283 (70%)
gsk-3	NP_001379044.1	STKc_GSK3	31..323	CDD:271039	203/291 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I751
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D990896at2759
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		otm14465
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.800