DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12056 and CYB5D2

DIOPT Version :9

Sequence 1:	NP_572535.1	Gene:	CG12056 / 31855	FlyBaseID:	FBgn0030099	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_653212.1	Gene:	CYB5D2 / 124936	HGNCID:	28471	Length:	264	Species:	Homo sapiens

Alignment Length:	235	Identity:	96/235 - (40%)
Similarity:	125/235 - (53%)	Gaps:	21/235 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LFTPAELAKFNGEEEGRPLYLALLGSVFDVSRGIKHYGSGCSYNFFVGRDASVSFISGDFETYDP 127
            ||.|.||:::.|......|||||||.|:|||.|.:||..|..|:.|.|||||.:|::||..  :.
Human    37 LFIPEELSRYRGGPGDPGLYLALLGRVYDVSSGRRHYEPGSHYSGFAGRDASRAFVTGDCS--EA 99

  Fly   128 ETADDVLTLKPDDLIGLAGWRDFYQKDYVYKGRVIGRFYDEKG----ALTTYHHKFLELLEQARD 188
            ...|||..|...:::.|..|..||:|:||..|||.||||.|.|    |||.........||.
Human   100 GLVDDVSDLSAAEMLTLHNWLSFYEKNYVCVGRVTGRFYGEDGLPTPALTQVEAAITRGLEA--- 161

  Fly   189 AKRQVEELRARYPGCNIEWSEERGTRVWCTTTSGDGKERSWIGYPRKLYSRGNKSFQCACV---- 249
            .|.|::| :..:|.||.|||..||:|:||:..|| |..|.|||.|||||..|.|..:|.||
Human   162 NKLQLQE-KQTFPPCNAEWSSARGSRLWCSQKSG-GVSRDWIGVPRKLYKPGAKEPRCVCVRTTG 224

  Fly   250 -PDAELDEIDA---GGKVAHGDAMLKPYDNCEPQARECFY 285
             |..::.:...   .|.:.|.:  |..|..|.|.|..|.:
Human   225 PPSGQMPDNPPHRNRGDLDHPN--LAEYTGCPPLAITCSF 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12056	NP_572535.1	Cyt-b5	63..>117	CDD:278597	28/53 (53%)
CYB5D2	NP_653212.1	Cyt-b5	40..>100	CDD:306642	29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147910
Domainoid	1	1.000	79	1.000	Domainoid score	I8760
eggNOG	1	0.900	-	-		E1_KOG1110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14701
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4310
Isobase	1	0.950	-	0	Normalized mean entropy	S2222
OMA	1	1.010	-	-		QHG59781
OrthoDB	1	1.010	-	-		D1355837at2759
OrthoFinder	1	1.000	-	-		FOG0006068
OrthoInspector	1	1.000	-	-		oto88398
orthoMCL	1	0.900	-	-		OOG6_104240
Panther	1	1.100	-	-	LDO	PTHR10281
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2676
SonicParanoid	1	1.000	-	-		X4364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750