DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zpr1 and ZPR1

DIOPT Version :9

Sequence 1:	NP_572532.1	Gene:	Zpr1 / 31851	FlyBaseID:	FBgn0030096	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_003895.1	Gene:	ZPR1 / 8882	HGNCID:	13051	Length:	459	Species:	Homo sapiens

Alignment Length:	451	Identity:	219/451 - (48%)
Similarity:	302/451 - (66%)	Gaps:	21/451 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PNSSNPPESAGNIRPEPIFREINAE-QTDEIVEVESACMNCFETGVTRLLPTKIPFFREVVLMSF 70
            |..:.||      .|:.:||.|:|| :..:..|:||.||||:..|:||||.||||||||:::.||
Human    20 PAPAPPP------APDHLFRPISAEDEEQQPTEIESLCMNCYCNGMTRLLLTKIPFFREIIVSSF 78

  Fly    71 KCDHCGHINNEMQSASEIQKSGIRIELRVQSVADLNRRVVRSDNSSISIPEIELEIPVQSQKGEV 135
            .|:|||..|.|:|||..||..|:|..|.|:::.|:||.||::|:::..|||::.|||..||||.:
Human    79 SCEHCGWNNTEIQSAGRIQDQGVRYTLSVRALEDMNREVVKTDSAATRIPELDFEIPAFSQKGAL 143

  Fly   136 TTVEGIIERTIAGLSQDQEKRRIDHPETAASIEKYIERLHRLKEVTTPFQVLLEDISGNSFIENP 200
            |||||:|.|.|:||.|||..||.:...||..|:::|.:|..||:|.:||.::::|.|||||:|||
Human   144 TTVEGLITRAISGLEQDQPARRANKDATAERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENP 208

  Fly   201 LAPAADPQLKTSYFTRSQQQNEQLGLYEQNHEEQHLLKPIAEDSWPIENLHGEVLQFPTNCPSCQ 265
            .||..|..|..:::.|::||.|.|||.|:...|    ||..||      |..|||||.||||.|.
Human   209 HAPQKDDALVITHYNRTRQQEEMLGLQEEAPAE----KPEEED------LRNEVLQFSTNCPECN 263

  Fly   266 APCETNMKLTNIPHFKEVVIMATVCGACGHKTNEVKSGGGVEAQGVRFRVQIASREDLTRDVLKS 330
            ||.:|||||..|||||||:||||.|..|||:||||||||.||..|.|..:.|....|:|||:|||
Human   264 APAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDASDMTRDLLKS 328

  Fly   331 ETCSMSIPELDLEVGPHALCGRFTTVEGLLVAMRDQLDGTLF--HDSADDATKQQMQRFLDTFED 393
            ||||:.||||:.|:|...|.|:|||:||||..:|:.:....|  .||::....:::|.|....:.
Human   329 ETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPGQTERLQEFSQKMDQ 393

  Fly   394 VMNLKRVITLVLEDPAGNTYVQSLSDDDSEPDDKLTVERYDRSYEDNEDLGLNDMKTEGYE 454
            ::........:::|||||:|:|::...:.:|:.|  ||||.|:::.||:||||||||||||
Human   394 IIEGNMKAHFIMDDPAGNSYLQNVYAPEDDPEMK--VERYKRTFDQNEELGLNDMKTEGYE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zpr1	NP_572532.1	Zpr1	41..199	CDD:128949	82/157 (52%)
Zpr1	NP_572532.1	Zpr1	259..416	CDD:128949	78/158 (49%)
ZPR1	NP_003895.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		4/17 (24%)
		zf-ZPR1	49..206	CDD:281375	82/156 (53%)
		Zpr1	257..416	CDD:128949	78/158 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..459		13/14 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159318
Domainoid	1	1.000	178	1.000	Domainoid score	I3592
eggNOG	1	0.900	-	-		E1_COG1779
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2900
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1759
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54073
OrthoDB	1	1.010	-	-		D250130at33208
OrthoFinder	1	1.000	-	-		FOG0004365
OrthoInspector	1	1.000	-	-		oto91174
orthoMCL	1	0.900	-	-		OOG6_101443
Panther	1	1.100	-	-	LDO	PTHR10876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3087
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770